Elig.phs001299.v2.p1.1
Item
An affected full sibling pair design, with the inclusion of any additional affected full siblings in the family, both biological parents (when available), and (if one or both parents are unavailable for study) unaffected full siblings who have been exposed to nicotine (i.e., have smoked at least once or twice), but never became regular smokers (i.e., smoked fewer than 100 cigarettes in their life) to help compensate for the loss of information due to missing parental phenotypes. This design permits affected sib pair analyses and TDT (including sib-TDT) analyses.
boolean
C0522476 (UMLS CUI [1,1])
C0037047 (UMLS CUI [1,2])
C1709450 (UMLS CUI [1,3])
C1707689 (UMLS CUI [1,4])
C1512693 (UMLS CUI [2,1])
C1524062 (UMLS CUI [2,2])
C0522476 (UMLS CUI [2,3])
C0037047 (UMLS CUI [2,4])
C1512693 (UMLS CUI [3,1])
C1706086 (UMLS CUI [3,2])
C0337465 (UMLS CUI [3,3])
C1512693 (UMLS CUI [4,1])
C1524062 (UMLS CUI [4,2])
C0037047 (UMLS CUI [4,3])
C0522477 (UMLS CUI [4,4])
C0332157 (UMLS CUI [4,5])
C0543414 (UMLS CUI [4,6])
C1298908 (UMLS CUI [4,7])
C0205272 (UMLS CUI [4,8])
C0543414 (UMLS CUI [4,9])
C0205432 (UMLS CUI [4,10])
C4524803 (UMLS CUI [4,11])
C1707689 (UMLS CUI [5,1])
C0522476 (UMLS CUI [5,2])
C0037047 (UMLS CUI [5,3])
C1709450 (UMLS CUI [5,4])
C0936012 (UMLS CUI [5,5])
Elig.phs001299.v2.p1.2
Item
Australia has a large national twin panel in which smoking data were collected prospectively over a period of many years (from 1980-82 onwards). Heavy smoking cases were identified from these panels. In the case of MZ twin pairs concordant for heavy smoking, one twin, with preference given to a twin who also met criteria for nicotine dependence, was selected as the index case, and the MZ co-twin can be discarded from traditional analyses.
boolean
C0004340 (UMLS CUI [1,1])
C0041427 (UMLS CUI [1,2])
C3846158 (UMLS CUI [1,3])
C0033522 (UMLS CUI [1,4])
C1516698 (UMLS CUI [1,5])
C1519386 (UMLS CUI [1,6])
C1511726 (UMLS CUI [1,7])
C0337669 (UMLS CUI [2,1])
C0600091 (UMLS CUI [2,2])
C3846158 (UMLS CUI [2,3])
C0041427 (UMLS CUI [3,1])
C4553529 (UMLS CUI [3,2])
C0337669 (UMLS CUI [3,3])
C0558295 (UMLS CUI [4,1])
C0041427 (UMLS CUI [4,2])
C1550543 (UMLS CUI [4,3])
C0243161 (UMLS CUI [4,4])
C0028043 (UMLS CUI [4,5])
C0242802 (UMLS CUI [4,6])
C2597943 (UMLS CUI [4,7])
C0205394 (UMLS CUI [5,1])
C0041427 (UMLS CUI [5,2])
C4699982 (UMLS CUI [5,3])