Elig.phs001366.v1.p1.1
Item
To participate, patients must have been age ≥18 and willing to undergo a fresh tumor biopsy. Other eligibility criteria included: Karnofsky performance status ≥70%, life expectancy <3 months, and baseline laboratory data indicating acceptable bone marrow reserve, liver, and renal function. Main exclusion criteria were symptomatic or untreated central nervous system (CNS) metastases, known active infections requiring intravenous antimicrobial therapy, pregnant or breast-feeding women, or tumor that was inaccessible for an adequate biopsy. Participation on another clinical trial involving treatment prior to or during participation on this study was allowed.
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