*PARTICIPANTS*
Item
*PARTICIPANTS*
boolean
C3165543 (UMLS CUI [1,1])
*Inclusion Criteria:*
Item
*Inclusion Criteria:*
boolean
C1512693 (UMLS CUI [1,1])
Male and female participants were included who met the following criteria:Outpatients or inpatients with nonpsychotic MDD for whom antidepressant treatment is deemed appropriate by the treating clinician.
Item
Male and female participants were included who met the following criteria:Outpatients or inpatients with nonpsychotic MDD for whom antidepressant treatment is deemed appropriate by the treating clinician.
boolean
C0086582 (UMLS CUI [1,1])
C0086287 (UMLS CUI [1,2])
C0679646 (UMLS CUI [1,3])
C1512693 (UMLS CUI [1,4])
C0243161 (UMLS CUI [1,5])
C0029921 (UMLS CUI [1,6])
C0021562 (UMLS CUI [1,7])
C1269683 (UMLS CUI [1,8])
C1741963 (UMLS CUI [1,9])
C1522326 (UMLS CUI [1,10])
C0871685 (UMLS CUI [1,11])
A baseline score of >/= 14 on the HRS-D17.
Item
A baseline score of >/= 14 on the HRS-D17.
boolean
C1442488 (UMLS CUI [1,1])
C0449820 (UMLS CUI [1,2])
C0451203 (UMLS CUI [1,3])
Age 18-85 years.
Item
Age 18-85 years.
boolean
C0001779 (UMLS CUI [1,1])
*Exclusion Criteria:*Subjects with medical contraindications that precluded citalopram or escitalopram treatment and those who previously failed to respond to citalopram or escitalopram were excluded.
Item
*Exclusion Criteria:*Subjects with medical contraindications that precluded citalopram or escitalopram treatment and those who previously failed to respond to citalopram or escitalopram were excluded.
boolean
C0680251 (UMLS CUI [1,1])
C1099456 (UMLS CUI [1,2])
C0008845 (UMLS CUI [1,3])
C1553423 (UMLS CUI [1,4])
C0231175 (UMLS CUI [1,5])
C0087111 (UMLS CUI [1,6])
C0681850 (UMLS CUI [1,7])
C1301624 (UMLS CUI [1,8])
Patients with schizophrenia, schizoaffective disorder, or who have Bipolar I disorder were excluded.
Item
Patients with schizophrenia, schizoaffective disorder, or who have Bipolar I disorder were excluded.
boolean
C0030705 (UMLS CUI [1,1])
C0036341 (UMLS CUI [1,2])
C0036337 (UMLS CUI [1,3])
C0005586 (UMLS CUI [1,4])
C0680251 (UMLS CUI [1,5])
Subjects who were on antidepressant medication with subtherapeutic results in terms of depression management underwent a medication taper and discontinuation prior to initiation of citalopram or escitalopram treatment. The subjects were closely monitored by the primary physican or psychiatrist during the medication taper and discontinuation phase. The medication taper was determined by the treating physician or psychiatrist. Study subjects who could not be safely tapered from their medication or experienced adverse effects during the taper were excluded from the study.
Item
Subjects who were on antidepressant medication with subtherapeutic results in terms of depression management underwent a medication taper and discontinuation prior to initiation of citalopram or escitalopram treatment. The subjects were closely monitored by the primary physican or psychiatrist during the medication taper and discontinuation phase. The medication taper was determined by the treating physician or psychiatrist. Study subjects who could not be safely tapered from their medication or experienced adverse effects during the taper were excluded from the study.
boolean
C0681850 (UMLS CUI [1,1])
C0003289 (UMLS CUI [1,2])
C1262236 (UMLS CUI [1,3])
C1303151 (UMLS CUI [1,4])
C0441640 (UMLS CUI [1,5])
C0013227 (UMLS CUI [1,6])
C0457454 (UMLS CUI [1,7])
C0332152 (UMLS CUI [1,8])
C1704686 (UMLS CUI [1,9])
C1099456 (UMLS CUI [1,10])
C0008845 (UMLS CUI [1,11])
C1822343 (UMLS CUI [1,12])
C1508823 (UMLS CUI [1,13])
C0033872 (UMLS CUI [1,14])
C0680251 (UMLS CUI [1,15])
Subjects using the antidepressant medication for management of nicotine dependence, chronic pain, migraine prophylaxis or other diagnoses were not eligible for the study.
Item
Subjects using the antidepressant medication for management of nicotine dependence, chronic pain, migraine prophylaxis or other diagnoses were not eligible for the study.
boolean
C0681850 (UMLS CUI [1,1])
C0003289 (UMLS CUI [1,2])
C0028043 (UMLS CUI [1,3])
C0150055 (UMLS CUI [1,4])
C1142085 (UMLS CUI [1,5])
C1555471 (UMLS CUI [1,6])
Study subjects who were on antipsychotic medications (e.g., typical and atypical antipsychotic drugs) and mood stabilizing agents (e.g., lithium, carbamazepine, valproate, lamotrigine, gabapentin, or other anticonvulsants) were not eligible for the study with the exception of those starting quetiapine after baseline. Trazadone, Melatonin, and Diphenhydramine were allowed for use as rescue medications for insomnia. Benzodiazepines were allowed for treatment of anxiety and atomoxetine for the treatment of attention deficit disorder.
Item
Study subjects who were on antipsychotic medications (e.g., typical and atypical antipsychotic drugs) and mood stabilizing agents (e.g., lithium, carbamazepine, valproate, lamotrigine, gabapentin, or other anticonvulsants) were not eligible for the study with the exception of those starting quetiapine after baseline. Trazadone, Melatonin, and Diphenhydramine were allowed for use as rescue medications for insomnia. Benzodiazepines were allowed for treatment of anxiety and atomoxetine for the treatment of attention deficit disorder.
boolean
C0681850 (UMLS CUI [1,1])
C2917392 (UMLS CUI [1,2])
C1276996 (UMLS CUI [1,3])
C1276998 (UMLS CUI [1,4])
C0003286 (UMLS CUI [1,5])
C0060926 (UMLS CUI [1,6])
C0064636 (UMLS CUI [1,7])
C0080356 (UMLS CUI [1,8])
C0006949 (UMLS CUI [1,9])
C0023870 (UMLS CUI [1,10])
C1555471 (UMLS CUI [1,11])
C0123091 (UMLS CUI [1,12])
C1442488 (UMLS CUI [1,13])
C0012522 (UMLS CUI [2,1])
C0025219 (UMLS CUI [2,2])
C0040805 (UMLS CUI [2,3])
C0683607 (UMLS CUI [2,4])
C5237476 (UMLS CUI [2,5])
C0917801 (UMLS CUI [2,6])
C0005064 (UMLS CUI [3,1])
C0683607 (UMLS CUI [3,2])
C0087111 (UMLS CUI [3,3])
C0003467 (UMLS CUI [3,4])
C0076823 (UMLS CUI [4,1])
C0683607 (UMLS CUI [4,2])
C0087111 (UMLS CUI [4,3])
C0041671 (UMLS CUI [4,4])
Subjects unable to give informed consent were excluded.
Item
Subjects unable to give informed consent were excluded.
boolean
C0681850 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C0680251 (UMLS CUI [1,4])
Pregnant subjects were excluded.
Item
Pregnant subjects were excluded.
boolean
C0680251 (UMLS CUI [1,1])
C0681850 (UMLS CUI [1,2])
C0032961 (UMLS CUI [1,3])