The dataset includes data obtained with the HRSD and QIDS questionnaires at baseline and following 4- or 8-weeks of medication with citalopram or escitalopram, in addition to height/weight measures, and general socio-demographic information. Data of drug efficacy, remission/response to medication, and compliance with the medication protocol (subjects excluded when non-compliant) are included as well.

5 Formulare

StudyEvent: SEV1

Name

Typ

Description | Question | Decode (Coded Value)

Datentyp

Alias

pht003556

Item Group

pht003556

C3846158 (UMLS CUI [1,1])

SUBJID

Item

De-identified Subject ID

text

C4684638 (UMLS CUI [1,1])
C2348585 (UMLS CUI [1,2])

lookup.race

Item

Race description

string

C0034510 (UMLS CUI [1,1])

race

Item

Race code

string

C0034510 (UMLS CUI [1,1])

gender

Item

Gender

string

C0079399 (UMLS CUI [1,1])

age

Item

Age at Consent

text

C0001779 (UMLS CUI [1,1])
C0021430 (UMLS CUI [1,2])

qidsctotal.b

Item

QIDSC (Quick Inventory of Depressive Symptomatology) total score at Baseline

text

C4720917 (UMLS CUI [1,1])
C2964552 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])

hrsdtotal.b

Item

HRSD (Hamilton Rating Scale for Depression) total score at Baseline

text

C0451203 (UMLS CUI [1,1])
C2964552 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])

qidsctotal.w4

Item

QIDSC total score at Week 4

text

C4720917 (UMLS CUI [1,1])
C2964552 (UMLS CUI [1,2])
C0439230 (UMLS CUI [1,3])

remissionqids.w4

Item

QIDSC remission status at Week 4 (Remitter if QIDSCTotal_W4 < =5, Non Remitter if QIDSCTotal_W4 > 5)

string

C4720917 (UMLS CUI [1,1])
C0544452 (UMLS CUI [1,2])
C0439230 (UMLS CUI [1,3])

qidscpctchange.w4

Item

(([QIDSCTotal_W4]-[QIDSCTotal_B])/[QIDSCTotal_B]*100)

text

C4720917 (UMLS CUI [1,1])
C0439810 (UMLS CUI [1,2])

qids.response2.w4

Item

Responder if QIDSCpctChange_W4 > = 50 , Non Responder if QIDSCpctChange_W4 < 50

string

C4720917 (UMLS CUI [1,1])
C1704632 (UMLS CUI [1,2])

qidsctotal.w8

Item

QIDSC total score at Week8

text

C4720917 (UMLS CUI [1,1])
C2964552 (UMLS CUI [1,2])
C0439230 (UMLS CUI [1,3])

remissionqids.w8

Item

QIDSC remission status at Week 8 (Remitter if QIDSCTotal_W8 < =5, Non Remitter if QIDSCTotal_W8 > 5)

string

C4720917 (UMLS CUI [1,1])
C0544452 (UMLS CUI [1,2])
C0439230 (UMLS CUI [1,3])

qidscpctchange.w8

Item

(([QIDSCTotal_W8]-[QIDSCTotal_B])/[QIDSCTotal_B]*100)

text

C4720917 (UMLS CUI [1,1])
C0439810 (UMLS CUI [1,2])

qids.response2.w8

Item

Responder if QIDSCpctChange_W8 >= 50 , Non Responder if QIDSCpctChange_W8 < 50

string

C4720917 (UMLS CUI [1,1])
C1704632 (UMLS CUI [1,2])

med.b

Item

Medication at Baseline (citalopram/escitalopram)

string

C0013227 (UMLS CUI [1,1])
C1442488 (UMLS CUI [1,2])
C0008845 (UMLS CUI [1,3])
C1099456 (UMLS CUI [1,4])

dose.b

Item

Dose of med.b drug prescribed at Baseline

float

C0678766 (UMLS CUI [1,1])
C3166216 (UMLS CUI [1,2])
C1442488 (UMLS CUI [1,3])

dose.w4

Item

Dose of drug (citalopram/escitalopram) subject is taking on their Week 4 visit

float

C0678766 (UMLS CUI [1,1])
C1099456 (UMLS CUI [1,2])
C0008845 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])

dose.w8

Item

Dose of drug (citalopram/escitalopram) subject is taking on their Week 8 visit

float

C0678766 (UMLS CUI [1,1])
C0008845 (UMLS CUI [1,2])
C1099456 (UMLS CUI [1,3])
C0439230 (UMLS CUI [1,4])

height

Item

Baseline Height

float

C1442488 (UMLS CUI [1,1])
C0005890 (UMLS CUI [1,2])

weight

Item

Baseline Weight

float

C1442488 (UMLS CUI [1,1])
C0005910 (UMLS CUI [1,2])

maritalstatus

Item

Marital status

string

C0024819 (UMLS CUI [1,1])

livewithspouse

Item

Indicator of whether subject lives with spouse

text

C2184147 (UMLS CUI [1,1])

livewithspouse

Code List

Indicator of whether subject lives with spouse

CL Item

Yes (1)

CL Item

No (2)

CL Item

Unknown (3)

yearsschool

Item

Total number of years completed

text

C4288115 (UMLS CUI [1,1])
C0439234 (UMLS CUI [1,2])
C1556116 (UMLS CUI [1,3])

highdegree

Item

Highest degree completed

text

C4264309 (UMLS CUI [1,1])

highdegree

Code List

Highest degree completed

CL Item

None (1)

CL Item

GED (2)

CL Item

High School Diploma (3)

CL Item

Some College (4)

CL Item

Associates Degree/Technical Degree (5)

CL Item

College Diploma (6)

CL Item

Masters Degree (7)

CL Item

Doctorate or Professional Degree (e.g. MD, PhD, JD) (8)

currentstudent

Item

Is subject currently in school

text

C2136038 (UMLS CUI [1,1])

currentstudent

Code List

Is subject currently in school

CL Item

No (1)

CL Item

Full-time (2)

CL Item

Part-time (3)

currentempstat

Item

Current employment status

text

C0242271 (UMLS CUI [1,1])

currentempstat

Code List

Current employment status

CL Item

Unemployed,not looking (1)

CL Item

Unemployed, looking (2)

CL Item

Full-time employed (3)

CL Item

Part-time employed (4)

CL Item

Self-employed (5)

CL Item

Retired not working (6)

ageonset

Item

Age at onset of first major depressive episode

text

C0206132 (UMLS CUI [1,1])
C0024517 (UMLS CUI [1,2])
C0205435 (UMLS CUI [1,3])

seasonalpattern

Item

Is there a seasonal pattern to your depression

text

C0085159 (UMLS CUI [1,1])
C0011570 (UMLS CUI [1,2])

seasonalpattern

Code List

Is there a seasonal pattern to your depression

CL Item

Yes (1)

CL Item

No (2)

CL Item

Unknown (3)

psychotherapy

Item

Are you currently involved in psychotherapy

text

C0033968 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])

psychotherapy

Code List

Are you currently involved in psychotherapy

CL Item

Yes (1)

CL Item

No (2)

CL Item

Unknown (3)

remission

Item

Last visit remission defined as Remitter if last visit QIDS C <= 5, Non Remitter if last visit QIDSC > 5. If no W4 or W8 data then remission defined as Non Remitter.

string

C4720917 (UMLS CUI [1,1])
C0544452 (UMLS CUI [1,2])
C0545082 (UMLS CUI [1,3])

response

Item

Last-visit response defined as Responder if QIDSCpctChange >=50 , Non Responder if QIDSCpctChange < 50. If no W4 or W8 data then response defined as Non Responder

text

C4720917 (UMLS CUI [1,1])
C0545082 (UMLS CUI [1,2])
C1704632 (UMLS CUI [1,3])

response

Code List

Last-visit response defined as Responder if QIDSCpctChange >=50 , Non Responder if QIDSCpctChange < 50. If no W4 or W8 data then response defined as Non Responder

CL Item

Non-Responder (Non-Responder)

CL Item

Responder (Responder)

qidscpctchange

Item

Difference between final visit QIDSC and baseline QIDSC, divided by baseline QIDSC and multiplied by 100. If no W4 or W8 data then change set to 0.

float

C4720917 (UMLS CUI [1,1])
C1705241 (UMLS CUI [1,2])
C5204638 (UMLS CUI [1,3])
C5204632 (UMLS CUI [1,4])

IsExcluded

Item

Indicator of whether subject was excluded from GWAS

string

C2350277 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])

ExclusionReason

Item

Non-Caucasian = Subject deemed non caucasian based on self-reported race and Structure Analyses Non-Compliant = Subject was deemed non compliant

string

C0034510 (UMLS CUI [1,1])
C1518422 (UMLS CUI [1,2])
C0007457 (UMLS CUI [1,3])
C2700446 (UMLS CUI [1,4])
C0936012 (UMLS CUI [1,5])
C0457432 (UMLS CUI [1,6])

consentMonth

Item

Month subject consented to study

text

C2711213 (UMLS CUI [1,1])
C0439231 (UMLS CUI [1,2])

consentYear

Item

Year subject consented to study

text

C2711213 (UMLS CUI [1,1])
C0439234 (UMLS CUI [1,2])

currentonsetMonth

Item

Month of onset for current major depression episode

text

C0439231 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
C0521116 (UMLS CUI [1,3])
C0024517 (UMLS CUI [1,4])

currentonsetYear

Item

Year of onset for current major depression episode

text

C0439234 (UMLS CUI [1,1])
C0332162 (UMLS CUI [1,2])
C0521116 (UMLS CUI [1,3])
C0024517 (UMLS CUI [1,4])

EVEC.1

Item

1st eigenvector from principal components analysis used as a covariate in adjusted GWAS

float

C3846158 (UMLS CUI [1,1])
C0429865 (UMLS CUI [1,2])
C4684740 (UMLS CUI [1,3])
C2350277 (UMLS CUI [1,4])

EVEC.2

Item

2nd eigenvector from principal components analysis used as a covariate in adjusted GWAS

float

C3846158 (UMLS CUI [1,1])
C0429865 (UMLS CUI [1,2])
C4684740 (UMLS CUI [1,3])
C2350277 (UMLS CUI [1,4])

EVEC.3

Item

3rd eigenvector from principal components analysis used as a covariate in adjusted GWAS

float

C3846158 (UMLS CUI [1,1])
C0429865 (UMLS CUI [1,2])
C4684740 (UMLS CUI [1,3])
C2350277 (UMLS CUI [1,4])

EVEC.4

Item

4th eigenvector from principal components analysis used as a covariate in adjusted GWAS

float

C3846158 (UMLS CUI [1,1])
C0429865 (UMLS CUI [1,2])
C4684740 (UMLS CUI [1,3])
C2350277 (UMLS CUI [1,4])

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