Item Group
Inclusion and exclusion criteria
C1512693 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
The selected multiplex epilepsy families contained an average of 3.8 (range 2-8) individuals per family with non-acquired (idiopathic or unknown cause) epilepsy, and an average of 3.9 (range 2-9) individuals with non-acquired epilepsy or isolated unprovoked seizures. Genome-wide linkage analysis was carried out in each family using a panel of microsatellite markers; no significant linkage peaks (LOD >3.0) were identified in any individual family. We selected a total of 29 families, including 6 families with focal epilepsy, 13 families with idiopathic generalized epilepsy (IGE) and 10 families with a mix of IGE and focal epilepsy. For the majority of families we sequenced multiple distantly related family members (usually 2) and for the IGE only families we sequenced just a single affected family member for 12 of these 13 families.
Item
The selected multiplex epilepsy families contained an average of 3.8 (range 2-8) individuals per family with non-acquired (idiopathic or unknown cause) epilepsy, and an average of 3.9 (range 2-9) individuals with non-acquired epilepsy or isolated unprovoked seizures. Genome-wide linkage analysis was carried out in each family using a panel of microsatellite markers; no significant linkage peaks (LOD >3.0) were identified in any individual family. We selected a total of 29 families, including 6 families with focal epilepsy, 13 families with idiopathic generalized epilepsy (IGE) and 10 families with a mix of IGE and focal epilepsy. For the majority of families we sequenced multiple distantly related family members (usually 2) and for the IGE only families we sequenced just a single affected family member for 12 of these 13 families.
boolean
C0014544 (UMLS CUI [1,1])
C0015576 (UMLS CUI [1,2])
C0391957 (UMLS CUI [1,3])
C0393709 (UMLS CUI [1,4])
C0796345 (UMLS CUI [1,5])
C1882416 (UMLS CUI [1,6])
C0023745 (UMLS CUI [1,7])
C0014547 (UMLS CUI [1,8])
C0270850 (UMLS CUI [1,9])