Participants (all non-smoking female) were drawn from studies in Eastern Asia. Cases were histologically confirmed lung cancer.
Item
Participants (all non-smoking female) were drawn from studies in Eastern Asia. Cases were histologically confirmed lung cancer.
boolean
C4554048 (UMLS CUI [1,1])
C0086287 (UMLS CUI [1,2])
C0337672 (UMLS CUI [1,3])
C0947630 (UMLS CUI [1,4])
C0015631 (UMLS CUI [1,5])
C0019638 (UMLS CUI [1,6])
C0521091 (UMLS CUI [1,7])
C0242379 (UMLS CUI [1,8])
Exclusions included: (i) samples with low completion rates; (ii) samples with extreme mean heterozygosity rates. The thresholds were chosen based on the sample completion rates or sample mean heterozygosity distribution by each QC group; and (iii) discordant expected duplicate samples. The average genotype concordance rate for the expected duplicates was great than 99.9%. Further QC at the individual level led to the following exclusions: (i) gender discordance; (ii) subjects with Asian ancestry less than 86%; (iii) subjects with first degree relatives in dataset; (iv) subjects with incomplete phenotype, ever smoked, unknown histology or ineligibility.
Item
Exclusions included: (i) samples with low completion rates; (ii) samples with extreme mean heterozygosity rates. The thresholds were chosen based on the sample completion rates or sample mean heterozygosity distribution by each QC group; and (iii) discordant expected duplicate samples. The average genotype concordance rate for the expected duplicates was great than 99.9%. Further QC at the individual level led to the following exclusions: (i) gender discordance; (ii) subjects with Asian ancestry less than 86%; (iii) subjects with first degree relatives in dataset; (iv) subjects with incomplete phenotype, ever smoked, unknown histology or ineligibility.
boolean
C0680251 (UMLS CUI [1,1])
C0205251 (UMLS CUI [1,2])
C1554962 (UMLS CUI [1,3])
C1521828 (UMLS CUI [1,4])
C0444504 (UMLS CUI [1,5])
C0019425 (UMLS CUI [1,6])
C0449864 (UMLS CUI [1,7])
C1517001 (UMLS CUI [1,8])
C0332597 (UMLS CUI [1,9])
C0370003 (UMLS CUI [1,10])
C4553529 (UMLS CUI [1,11])
C0017431 (UMLS CUI [1,12])
C0079399 (UMLS CUI [1,13])
C0034378 (UMLS CUI [1,14])
C1257906 (UMLS CUI [1,15])
C1517194 (UMLS CUI [1,16])
C0205257 (UMLS CUI [1,17])
C0031437 (UMLS CUI [1,18])
C3475470 (UMLS CUI [1,19])
C1512714 (UMLS CUI [1,20])
In addition, data from the GELAC study that was scanned using non-NIH Taiwan resources before Taiwan joined the FLCCA GWAS are not being posted. These data were scanned on the Ilumina 317 and 610. Further, data from 5 subjects from the Singapore study are not being posted, since these subjects indicated on their informed consent that they did not wish their data to be used by any other investigators except those in the Singapore study.
Item
In addition, data from the GELAC study that was scanned using non-NIH Taiwan resources before Taiwan joined the FLCCA GWAS are not being posted. These data were scanned on the Ilumina 317 and 610. Further, data from 5 subjects from the Singapore study are not being posted, since these subjects indicated on their informed consent that they did not wish their data to be used by any other investigators except those in the Singapore study.
boolean
C0947630 (UMLS CUI [1,1])
C0039260 (UMLS CUI [1,2])
C0035201 (UMLS CUI [1,3])
C2350277 (UMLS CUI [1,4])
C0681850 (UMLS CUI [1,5])
C0021430 (UMLS CUI [1,6])
C1524063 (UMLS CUI [1,7])
C1511726 (UMLS CUI [1,8])
C2346578 (UMLS CUI [1,9])