English

Eligibility Criteria

5 forms  
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID and consent group of participants with or without cancer and involved in the "Population Architecture Using Genomics and Epidemiology (PAGE): Epidemiologic Architecture for Genes Linked to Environment (EAGLE) - BioVU Cancer Project" project.
    3. Subject ID, sample ID and sample use variable obtained from participants with or without cancer and involved in the "Population Architecture Using Genomics and Epidemiology (PAGE): Epidemiologic Architecture for Genes Linked to Environment (EAGLE) - BioVU Cancer Project" project.
    4. Subject ID, age, sex, race, ethnicity, smoking status, smoking ICD9 code, CEU population, follow-up time of cancer participant visit, cancer status, cancer diagnosis, cancer site, CEU population, total population, smoking status, year of diagnosis, cancer type, cancer stage, breast cancer, colorectal cancer, lung cancer, melanoma, non-Hodgkin's lymphoma, ovarian cancer, prostate cancer, endometrial cancer, multiply cancer and follow-up time of cancer participant's visit of subjects with or without cancer and involved in the "Population Architecture Using Genomics and Epidemiology (PAGE): Epidemiologic Architecture for Genes Linked to Environment (EAGLE) - BioVU Cancer Project" project.
    5. Sample ID, body site where sample was collected [blood], analyte type, tumor status, and histological type of sample obtained from participants with or without cancer and involved in the "Population Architecture Using Genomics and Epidemiology (PAGE): Epidemiologic Architecture for Genes Linked to Environment (EAGLE) - BioVU Cancer Project" project.
Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Cancer cases and controls were identified using a combination of in-patient and out-patient data as well as tumor registry entries. These data include primary site designations and histology information collected for clinical reporting purposes for the North America Association of Central Cancer Registries. A combination of the tumor registry data, along with ICD-9 billing codes, procedure codes, vital signs, and free text clinical notes, were used to identify cases for eight cancers among all patients aged 18 or greater in the SD with DNA samples using the following algorithms:
Description

Cancer cases and controls were identified using a combination of in-patient and out-patient data as well as tumor registry entries. These data include primary site designations and histology information collected for clinical reporting purposes for the North America Association of Central Cancer Registries. A combination of the tumor registry data, along with ICD-9 billing codes, procedure codes, vital signs, and free text clinical notes, were used to identify cases for eight cancers among all patients aged 18 or greater in the SD with DNA samples using the following algorithms:

Data type

boolean

Alias
UMLS CUI [1,1]
C1706256
UMLS CUI [1,2]
C0009932
UMLS CUI [1,3]
C0205396
UMLS CUI [1,4]
C2707520
UMLS CUI [1,5]
C0805443
UMLS CUI [1,6]
C0449695
UMLS CUI [1,7]
C4048239
UMLS CUI [1,8]
C2826024
UMLS CUI [1,9]
C1136256
UMLS CUI [1,10]
C0518766
UMLS CUI [1,11]
C2066349
UMLS CUI [1,12]
C0001779
Breast cancer: Three or more mentions of ICD-9 primary code for malignant neoplasm of the female breast and all sub-codes on separate clinic visits OR a tumor registry entry for breast cancer AND female;
Description

Breast cancer: Three or more mentions of ICD-9 primary code for malignant neoplasm of the female breast and all sub-codes on separate clinic visits OR a tumor registry entry for breast cancer AND female;

Data type

boolean

Alias
UMLS CUI [1,1]
C0006142
UMLS CUI [1,2]
C1304708
UMLS CUI [1,3]
C1137111
UMLS CUI [1,4]
C0008952
UMLS CUI [1,5]
C0086287
Colorectal cancer: Tumor registry entry for colorectal cancer;
Description

Colorectal cancer: Tumor registry entry for colorectal cancer;

Data type

boolean

Alias
UMLS CUI [1,1]
C0009402
UMLS CUI [1,2]
C0805443
Endometrial cancer: Tumor registry entry for endometrial cancer AND histology AND female;
Description

Endometrial cancer: Tumor registry entry for endometrial cancer AND histology AND female;

Data type

boolean

Alias
UMLS CUI [1,1]
C0805443
UMLS CUI [1,2]
C0476089
UMLS CUI [1,3]
C0019638
UMLS CUI [1,4]
C0086287
Lung cancer: Tumor registry entry for lung cancer, any location and any type;
Description

Lung cancer: Tumor registry entry for lung cancer, any location and any type;

Data type

boolean

Alias
UMLS CUI [1,1]
C0805443
UMLS CUI [1,2]
C0684249
UMLS CUI [1,3]
C0450429
UMLS CUI [1,4]
C0030193
UMLS CUI [1,5]
C1552551
UMLS CUI [1,6]
C0332307
Melanoma: Three or more mentions of ICD-9 codes for malignant melanoma of skin OR tumor registry entry for melanoma;
Description

Melanoma: Three or more mentions of ICD-9 codes for malignant melanoma of skin OR tumor registry entry for melanoma;

Data type

boolean

Alias
UMLS CUI [1,1]
C0805443
UMLS CUI [1,2]
C0025202
UMLS CUI [1,3]
C1137111
Non-Hodgkin's lymphoma: Tumor registry entry for non-Hodgkin's lymphoma with histology;
Description

Non-Hodgkin's lymphoma: Tumor registry entry for non-Hodgkin's lymphoma with histology;

Data type

boolean

Alias
UMLS CUI [1,1]
C0805443
UMLS CUI [1,2]
C0024305
UMLS CUI [1,3]
C0019638
Ovarian cancer: Tumor registry entry for ovarian cancer AND female;
Description

Ovarian cancer: Tumor registry entry for ovarian cancer AND female;

Data type

boolean

Alias
UMLS CUI [1,1]
C0805443
UMLS CUI [1,2]
C0029925
UMLS CUI [1,3]
C0086287
Prostate cancer: Three or more mentions of ICD-9 codes for malignant neoplasm of prostate OR tumor registry entry for prostate cancer.
Description

Prostate cancer: Three or more mentions of ICD-9 codes for malignant neoplasm of prostate OR tumor registry entry for prostate cancer.

Data type

boolean

Alias
UMLS CUI [1,1]
C0805443
UMLS CUI [1,2]
C0600139
UMLS CUI [1,3]
C1137111
Approximately two control samples were identified per case. Controls were matched by sex, race/ethnicity (administratively assigned), and age (within five years of the cases). Controls were required to have at least two clinical narratives, with preference given to records with at least one fully documented history and physical. Exclusion criteria included records with one or more codes for neoplasms, records with a tumor registry entry, and records that had one or more cancer related keywords in the problem list.
Description

Approximately two control samples were identified per case. Controls were matched by sex, race/ethnicity (administratively assigned), and age (within five years of the cases). Controls were required to have at least two clinical narratives, with preference given to records with at least one fully documented history and physical. Exclusion criteria included records with one or more codes for neoplasms, records with a tumor registry entry, and records that had one or more cancer related keywords in the problem list.

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0009932
UMLS CUI [1,4]
C0150103
UMLS CUI [1,5]
C0015031
UMLS CUI [1,6]
C1522384
UMLS CUI [1,7]
C0001779
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C4553389
UMLS CUI [2,3]
C0205210
UMLS CUI [2,4]
C0600664
UMLS CUI [2,5]
C0443225
UMLS CUI [2,6]
C0262926
UMLS CUI [3,1]
C0680251
UMLS CUI [3,2]
C0034869
UMLS CUI [3,3]
C0346429
UMLS CUI [3,4]
C0805443
UMLS CUI [3,5]
C1708608
UMLS CUI [3,6]
C0332281
UMLS CUI [3,7]
C0006826
Additional control criteria are as follows:
Description

Additional control criteria are as follows:

Data type

boolean

Alias
UMLS CUI [1,1]
C0243148
UMLS CUI [1,2]
C0243161
Breast cancer controls are female only. For women over 40 years of age, we required that records contain at least one mammography Bi-Rad score as 1 (negative) or 2 (benign);
Description

Breast cancer controls are female only. For women over 40 years of age, we required that records contain at least one mammography Bi-Rad score as 1 (negative) or 2 (benign);

Data type

boolean

Alias
UMLS CUI [1,1]
C0006142
UMLS CUI [1,2]
C0086287
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C1514873
UMLS CUI [1,5]
C0025102
UMLS CUI [1,6]
C0024671
UMLS CUI [1,7]
C4480026
Endometrial cancer controls are female only;
Description

Endometrial cancer controls are female only;

Data type

boolean

Alias
UMLS CUI [1,1]
C0476089
UMLS CUI [1,2]
C0086287
Ovarian cancer controls are female only;
Description

Ovarian cancer controls are female only;

Data type

boolean

Alias
UMLS CUI [1,1]
C0029925
UMLS CUI [1,2]
C0086287
For colorectal cancer controls, we required for patients over 50 years of age the keyword "colonoscopy" in the problem list OR a procedure code for colonoscopy;
Description

For colorectal cancer controls, we required for patients over 50 years of age the keyword "colonoscopy" in the problem list OR a procedure code for colonoscopy;

Data type

boolean

Alias
UMLS CUI [1,1]
C0009402
UMLS CUI [1,2]
C4553389
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C1514873
UMLS CUI [1,5]
C1708608
UMLS CUI [1,6]
C0009378
UMLS CUI [1,7]
C0552582
UMLS CUI [1,8]
C1550373
Prostate cancer controls are male only. For male controls aged 40 years and greater to have at least one prostate specific antigen (PSA) level <4 and that the most recent PSA level is within the normal range.
Description

Prostate cancer controls are male only. For male controls aged 40 years and greater to have at least one prostate specific antigen (PSA) level <4 and that the most recent PSA level is within the normal range.

Data type

boolean

Alias
UMLS CUI [1,1]
C0600139
UMLS CUI [1,2]
C0086582
UMLS CUI [1,3]
C0001779
UMLS CUI [1,4]
C0201544
UMLS CUI [1,5]
C1513491
UMLS CUI [1,6]
C0086715
A total of 7,348 cases of cancer were identified in BioVU for targeted genotyping in EAGLE (Table).
Description

A total of 7,348 cases of cancer were identified in BioVU for targeted genotyping in EAGLE (Table).

Data type

boolean

Alias
UMLS CUI [1,1]
C1853237
UMLS CUI [1,2]
C3854164
UMLS CUI [1,3]
C0205396
*Table. Case counts by cancer and race/ethnicity.* Cases of specific cancers were determined in the de-identified electronic medical records within BioVU using algorithms implemented in late 2010/early 2011 as described in the text. Race/ethnicity was administratively assigned. *Cancer* *EA* *AA* *H* *A* *AI/NA* *O* *U* *Total* Breast 1,052 163 7 17 2 10 66 1,317 Colorectal 797 75 6 5 1 5 23 912 Endometrial 203 19 1 1 0 1 8 233 Lung 782 66 2 3 1 4 43 901 Melanoma 1,225 23 2 0 0 3 95 1,348 Non-Hodgkin's lymphoma 276 17 1 0 0 2 46 342 Ovarian 161 7 3 2 0 0 10 183 Prostate 1,895 172 4 2 0 7 32 2,112 Total 6,391 542 26 30 4 32 323 7,348
Description

*Table. Case counts by cancer and race/ethnicity.* Cases of specific cancers were determined in the de-identified electronic medical records within BioVU using algorithms implemented in late 2010/early 2011 as described in the text. Race/ethnicity was administratively assigned. *Cancer* *EA* *AA* *H* *A* *AI/NA* *O* *U* *Total* Breast 1,052 163 7 17 2 10 66 1,317 Colorectal 797 75 6 5 1 5 23 912 Endometrial 203 19 1 1 0 1 8 233 Lung 782 66 2 3 1 4 43 901 Melanoma 1,225 23 2 0 0 3 95 1,348 Non-Hodgkin's lymphoma 276 17 1 0 0 2 46 342 Ovarian 161 7 3 2 0 0 10 183 Prostate 1,895 172 4 2 0 7 32 2,112 Total 6,391 542 26 30 4 32 323 7,348

Data type

boolean

Alias
UMLS CUI [1,1]
C1706074
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0750480
UMLS CUI [1,4]
C0034510
Abbreviations: European American (EA), African American (AA), Hispanic (H), Asian (A), American Indian/Native Alaskan (AI/NA), Other (O), Unknown (U).
Description

Abbreviations: European American (EA), African American (AA), Hispanic (H), Asian (A), American Indian/Native Alaskan (AI/NA), Other (O), Unknown (U).

Data type

boolean

Alias
UMLS CUI [1,1]
C0000723
UMLS CUI [1,2]
C0085756
UMLS CUI [1,3]
C0683983
UMLS CUI [1,4]
C0086528
UMLS CUI [1,5]
C1515945
UMLS CUI [1,6]
C0078988
UMLS CUI [1,7]
C0205394
UMLS CUI [1,8]
C0439673
For the first five cancers defined in BioVU (breast, colorectal, melanoma, ovarian, and prostate cancers), we identified approximately two controls per case for genotyping as defined in the inclusion/exclusion criteria. A total of 8,996 controls were targeted for genotyping. Two controls per case of endometrial cancer, lung cancer, and non-Hodgkin's lymphoma were defined from among the genotyped control samples.
Description

For the first five cancers defined in BioVU (breast, colorectal, melanoma, ovarian, and prostate cancers), we identified approximately two controls per case for genotyping as defined in the inclusion/exclusion criteria. A total of 8,996 controls were targeted for genotyping. Two controls per case of endometrial cancer, lung cancer, and non-Hodgkin's lymphoma were defined from among the genotyped control samples.

Data type

boolean

Alias
UMLS CUI [1,1]
C0006826
UMLS CUI [1,2]
C1706256
UMLS CUI [1,3]
C0009932
UMLS CUI [1,4]
C0150103
UMLS CUI [1,5]
C0796344
UMLS CUI [1,6]
C0006142
UMLS CUI [1,7]
C0009402
UMLS CUI [1,8]
C0025202
UMLS CUI [1,9]
C1140680
UMLS CUI [1,10]
C0376358
UMLS CUI [2,1]
C0796344
UMLS CUI [2,2]
C0009932
UMLS CUI [2,3]
C2347026
UMLS CUI [2,4]
C0476089
UMLS CUI [2,5]
C0024305
UMLS CUI [2,6]
C0242379
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Eligibility Criteria

5 forms
  1. StudyEvent: SEV1
    1. Eligibility Criteria
    2. Subject ID and consent group of participants with or without cancer and involved in the "Population Architecture Using Genomics and Epidemiology (PAGE): Epidemiologic Architecture for Genes Linked to Environment (EAGLE) - BioVU Cancer Project" project.
    3. Subject ID, sample ID and sample use variable obtained from participants with or without cancer and involved in the "Population Architecture Using Genomics and Epidemiology (PAGE): Epidemiologic Architecture for Genes Linked to Environment (EAGLE) - BioVU Cancer Project" project.
    4. Subject ID, age, sex, race, ethnicity, smoking status, smoking ICD9 code, CEU population, follow-up time of cancer participant visit, cancer status, cancer diagnosis, cancer site, CEU population, total population, smoking status, year of diagnosis, cancer type, cancer stage, breast cancer, colorectal cancer, lung cancer, melanoma, non-Hodgkin's lymphoma, ovarian cancer, prostate cancer, endometrial cancer, multiply cancer and follow-up time of cancer participant's visit of subjects with or without cancer and involved in the "Population Architecture Using Genomics and Epidemiology (PAGE): Epidemiologic Architecture for Genes Linked to Environment (EAGLE) - BioVU Cancer Project" project.
    5. Sample ID, body site where sample was collected [blood], analyte type, tumor status, and histological type of sample obtained from participants with or without cancer and involved in the "Population Architecture Using Genomics and Epidemiology (PAGE): Epidemiologic Architecture for Genes Linked to Environment (EAGLE) - BioVU Cancer Project" project.
Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
Cancer cases and controls were identified using a combination of in-patient and out-patient data as well as tumor registry entries. These data include primary site designations and histology information collected for clinical reporting purposes for the North America Association of Central Cancer Registries. A combination of the tumor registry data, along with ICD-9 billing codes, procedure codes, vital signs, and free text clinical notes, were used to identify cases for eight cancers among all patients aged 18 or greater in the SD with DNA samples using the following algorithms:
Item
Cancer cases and controls were identified using a combination of in-patient and out-patient data as well as tumor registry entries. These data include primary site designations and histology information collected for clinical reporting purposes for the North America Association of Central Cancer Registries. A combination of the tumor registry data, along with ICD-9 billing codes, procedure codes, vital signs, and free text clinical notes, were used to identify cases for eight cancers among all patients aged 18 or greater in the SD with DNA samples using the following algorithms:
boolean
C1706256 (UMLS CUI [1,1])
C0009932 (UMLS CUI [1,2])
C0205396 (UMLS CUI [1,3])
C2707520 (UMLS CUI [1,4])
C0805443 (UMLS CUI [1,5])
C0449695 (UMLS CUI [1,6])
C4048239 (UMLS CUI [1,7])
C2826024 (UMLS CUI [1,8])
C1136256 (UMLS CUI [1,9])
C0518766 (UMLS CUI [1,10])
C2066349 (UMLS CUI [1,11])
C0001779 (UMLS CUI [1,12])
Breast cancer: Three or more mentions of ICD-9 primary code for malignant neoplasm of the female breast and all sub-codes on separate clinic visits OR a tumor registry entry for breast cancer AND female;
Item
Breast cancer: Three or more mentions of ICD-9 primary code for malignant neoplasm of the female breast and all sub-codes on separate clinic visits OR a tumor registry entry for breast cancer AND female;
boolean
C0006142 (UMLS CUI [1,1])
C1304708 (UMLS CUI [1,2])
C1137111 (UMLS CUI [1,3])
C0008952 (UMLS CUI [1,4])
C0086287 (UMLS CUI [1,5])
Colorectal cancer: Tumor registry entry for colorectal cancer;
Item
Colorectal cancer: Tumor registry entry for colorectal cancer;
boolean
C0009402 (UMLS CUI [1,1])
C0805443 (UMLS CUI [1,2])
Endometrial cancer: Tumor registry entry for endometrial cancer AND histology AND female;
Item
Endometrial cancer: Tumor registry entry for endometrial cancer AND histology AND female;
boolean
C0805443 (UMLS CUI [1,1])
C0476089 (UMLS CUI [1,2])
C0019638 (UMLS CUI [1,3])
C0086287 (UMLS CUI [1,4])
Lung cancer: Tumor registry entry for lung cancer, any location and any type;
Item
Lung cancer: Tumor registry entry for lung cancer, any location and any type;
boolean
C0805443 (UMLS CUI [1,1])
C0684249 (UMLS CUI [1,2])
C0450429 (UMLS CUI [1,3])
C0030193 (UMLS CUI [1,4])
C1552551 (UMLS CUI [1,5])
C0332307 (UMLS CUI [1,6])
Melanoma: Three or more mentions of ICD-9 codes for malignant melanoma of skin OR tumor registry entry for melanoma;
Item
Melanoma: Three or more mentions of ICD-9 codes for malignant melanoma of skin OR tumor registry entry for melanoma;
boolean
C0805443 (UMLS CUI [1,1])
C0025202 (UMLS CUI [1,2])
C1137111 (UMLS CUI [1,3])
Non-Hodgkin's lymphoma: Tumor registry entry for non-Hodgkin's lymphoma with histology;
Item
Non-Hodgkin's lymphoma: Tumor registry entry for non-Hodgkin's lymphoma with histology;
boolean
C0805443 (UMLS CUI [1,1])
C0024305 (UMLS CUI [1,2])
C0019638 (UMLS CUI [1,3])
Ovarian cancer: Tumor registry entry for ovarian cancer AND female;
Item
Ovarian cancer: Tumor registry entry for ovarian cancer AND female;
boolean
C0805443 (UMLS CUI [1,1])
C0029925 (UMLS CUI [1,2])
C0086287 (UMLS CUI [1,3])
Prostate cancer: Three or more mentions of ICD-9 codes for malignant neoplasm of prostate OR tumor registry entry for prostate cancer.
Item
Prostate cancer: Three or more mentions of ICD-9 codes for malignant neoplasm of prostate OR tumor registry entry for prostate cancer.
boolean
C0805443 (UMLS CUI [1,1])
C0600139 (UMLS CUI [1,2])
C1137111 (UMLS CUI [1,3])
Approximately two control samples were identified per case. Controls were matched by sex, race/ethnicity (administratively assigned), and age (within five years of the cases). Controls were required to have at least two clinical narratives, with preference given to records with at least one fully documented history and physical. Exclusion criteria included records with one or more codes for neoplasms, records with a tumor registry entry, and records that had one or more cancer related keywords in the problem list.
Item
Approximately two control samples were identified per case. Controls were matched by sex, race/ethnicity (administratively assigned), and age (within five years of the cases). Controls were required to have at least two clinical narratives, with preference given to records with at least one fully documented history and physical. Exclusion criteria included records with one or more codes for neoplasms, records with a tumor registry entry, and records that had one or more cancer related keywords in the problem list.
boolean
C1512693 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0009932 (UMLS CUI [1,3])
C0150103 (UMLS CUI [1,4])
C0015031 (UMLS CUI [1,5])
C1522384 (UMLS CUI [1,6])
C0001779 (UMLS CUI [1,7])
C1512693 (UMLS CUI [2,1])
C4553389 (UMLS CUI [2,2])
C0205210 (UMLS CUI [2,3])
C0600664 (UMLS CUI [2,4])
C0443225 (UMLS CUI [2,5])
C0262926 (UMLS CUI [2,6])
C0680251 (UMLS CUI [3,1])
C0034869 (UMLS CUI [3,2])
C0346429 (UMLS CUI [3,3])
C0805443 (UMLS CUI [3,4])
C1708608 (UMLS CUI [3,5])
C0332281 (UMLS CUI [3,6])
C0006826 (UMLS CUI [3,7])
Additional control criteria are as follows:
Item
Additional control criteria are as follows:
boolean
C0243148 (UMLS CUI [1,1])
C0243161 (UMLS CUI [1,2])
Breast cancer controls are female only. For women over 40 years of age, we required that records contain at least one mammography Bi-Rad score as 1 (negative) or 2 (benign);
Item
Breast cancer controls are female only. For women over 40 years of age, we required that records contain at least one mammography Bi-Rad score as 1 (negative) or 2 (benign);
boolean
C0006142 (UMLS CUI [1,1])
C0086287 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C1514873 (UMLS CUI [1,4])
C0025102 (UMLS CUI [1,5])
C0024671 (UMLS CUI [1,6])
C4480026 (UMLS CUI [1,7])
Endometrial cancer controls are female only;
Item
Endometrial cancer controls are female only;
boolean
C0476089 (UMLS CUI [1,1])
C0086287 (UMLS CUI [1,2])
Ovarian cancer controls are female only;
Item
Ovarian cancer controls are female only;
boolean
C0029925 (UMLS CUI [1,1])
C0086287 (UMLS CUI [1,2])
For colorectal cancer controls, we required for patients over 50 years of age the keyword "colonoscopy" in the problem list OR a procedure code for colonoscopy;
Item
For colorectal cancer controls, we required for patients over 50 years of age the keyword "colonoscopy" in the problem list OR a procedure code for colonoscopy;
boolean
C0009402 (UMLS CUI [1,1])
C4553389 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C1514873 (UMLS CUI [1,4])
C1708608 (UMLS CUI [1,5])
C0009378 (UMLS CUI [1,6])
C0552582 (UMLS CUI [1,7])
C1550373 (UMLS CUI [1,8])
Prostate cancer controls are male only. For male controls aged 40 years and greater to have at least one prostate specific antigen (PSA) level <4 and that the most recent PSA level is within the normal range.
Item
Prostate cancer controls are male only. For male controls aged 40 years and greater to have at least one prostate specific antigen (PSA) level <4 and that the most recent PSA level is within the normal range.
boolean
C0600139 (UMLS CUI [1,1])
C0086582 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0201544 (UMLS CUI [1,4])
C1513491 (UMLS CUI [1,5])
C0086715 (UMLS CUI [1,6])
A total of 7,348 cases of cancer were identified in BioVU for targeted genotyping in EAGLE (Table).
Item
A total of 7,348 cases of cancer were identified in BioVU for targeted genotyping in EAGLE (Table).
boolean
C1853237 (UMLS CUI [1,1])
C3854164 (UMLS CUI [1,2])
C0205396 (UMLS CUI [1,3])
*Table. Case counts by cancer and race/ethnicity.* Cases of specific cancers were determined in the de-identified electronic medical records within BioVU using algorithms implemented in late 2010/early 2011 as described in the text. Race/ethnicity was administratively assigned. *Cancer* *EA* *AA* *H* *A* *AI/NA* *O* *U* *Total* Breast 1,052 163 7 17 2 10 66 1,317 Colorectal 797 75 6 5 1 5 23 912 Endometrial 203 19 1 1 0 1 8 233 Lung 782 66 2 3 1 4 43 901 Melanoma 1,225 23 2 0 0 3 95 1,348 Non-Hodgkin's lymphoma 276 17 1 0 0 2 46 342 Ovarian 161 7 3 2 0 0 10 183 Prostate 1,895 172 4 2 0 7 32 2,112 Total 6,391 542 26 30 4 32 323 7,348
Item
*Table. Case counts by cancer and race/ethnicity.* Cases of specific cancers were determined in the de-identified electronic medical records within BioVU using algorithms implemented in late 2010/early 2011 as described in the text. Race/ethnicity was administratively assigned. *Cancer* *EA* *AA* *H* *A* *AI/NA* *O* *U* *Total* Breast 1,052 163 7 17 2 10 66 1,317 Colorectal 797 75 6 5 1 5 23 912 Endometrial 203 19 1 1 0 1 8 233 Lung 782 66 2 3 1 4 43 901 Melanoma 1,225 23 2 0 0 3 95 1,348 Non-Hodgkin's lymphoma 276 17 1 0 0 2 46 342 Ovarian 161 7 3 2 0 0 10 183 Prostate 1,895 172 4 2 0 7 32 2,112 Total 6,391 542 26 30 4 32 323 7,348
boolean
C1706074 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0750480 (UMLS CUI [1,3])
C0034510 (UMLS CUI [1,4])
Abbreviations: European American (EA), African American (AA), Hispanic (H), Asian (A), American Indian/Native Alaskan (AI/NA), Other (O), Unknown (U).
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Abbreviations: European American (EA), African American (AA), Hispanic (H), Asian (A), American Indian/Native Alaskan (AI/NA), Other (O), Unknown (U).
boolean
C0000723 (UMLS CUI [1,1])
C0085756 (UMLS CUI [1,2])
C0683983 (UMLS CUI [1,3])
C0086528 (UMLS CUI [1,4])
C1515945 (UMLS CUI [1,5])
C0078988 (UMLS CUI [1,6])
C0205394 (UMLS CUI [1,7])
C0439673 (UMLS CUI [1,8])
For the first five cancers defined in BioVU (breast, colorectal, melanoma, ovarian, and prostate cancers), we identified approximately two controls per case for genotyping as defined in the inclusion/exclusion criteria. A total of 8,996 controls were targeted for genotyping. Two controls per case of endometrial cancer, lung cancer, and non-Hodgkin's lymphoma were defined from among the genotyped control samples.
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For the first five cancers defined in BioVU (breast, colorectal, melanoma, ovarian, and prostate cancers), we identified approximately two controls per case for genotyping as defined in the inclusion/exclusion criteria. A total of 8,996 controls were targeted for genotyping. Two controls per case of endometrial cancer, lung cancer, and non-Hodgkin's lymphoma were defined from among the genotyped control samples.
boolean
C0006826 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0009932 (UMLS CUI [1,3])
C0150103 (UMLS CUI [1,4])
C0796344 (UMLS CUI [1,5])
C0006142 (UMLS CUI [1,6])
C0009402 (UMLS CUI [1,7])
C0025202 (UMLS CUI [1,8])
C1140680 (UMLS CUI [1,9])
C0376358 (UMLS CUI [1,10])
C0796344 (UMLS CUI [2,1])
C0009932 (UMLS CUI [2,2])
C2347026 (UMLS CUI [2,3])
C0476089 (UMLS CUI [2,4])
C0024305 (UMLS CUI [2,5])
C0242379 (UMLS CUI [2,6])
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