Elig.phs000452.v3.p1.1
Item
Primary tumor tissue samples, metastatic tumor tissue samples and metastatic short-term culture obtained from patients undergoing surgery for melanoma were selected based on high density of tumor tissue. DNA was extracted from tumor tissue or short-term culture and from either adjacent normal skin tissue (in the case of the primary tumor tissue samples) or blood for use as a normal DNA comparator. DNA was assessed for high quality and integrity on Affymetrix SNP 6.0 arrays and by agarose gel electrophoresis. SNP comparison was used to confirm that a sequenced tumor-normal pair could be attributed to the same individual and that no significant contamination by foreign DNA was present. Gross copy number analysis based on the SNP array data confirmed aberrant copy number in the case of the melanoma samples and diploid, unremarkable copy number profiles in the case of the normal samples.
boolean
C0025202 (UMLS CUI [1,1])
C0543467 (UMLS CUI [1,2])
C1268672 (UMLS CUI [1,3])
C0475358 (UMLS CUI [1,4])
C0677930 (UMLS CUI [1,5])
C0027627 (UMLS CUI [1,6])
C0443303 (UMLS CUI [1,7])
C0040284 (UMLS CUI [1,8])
C0012854 (UMLS CUI [2,1])
C0185115 (UMLS CUI [2,2])
C0475358 (UMLS CUI [2,3])
C0443303 (UMLS CUI [2,4])
C0040284 (UMLS CUI [2,5])
C0012854 (UMLS CUI [3,1])
C0185115 (UMLS CUI [3,2])
C0475358 (UMLS CUI [3,3])
C0677930 (UMLS CUI [3,4])
C0205117 (UMLS CUI [3,5])
C0684084 (UMLS CUI [3,6])
C0012854 (UMLS CUI [4,1])
C0185115 (UMLS CUI [4,2])
C0005767 (UMLS CUI [4,3])
C0012854 (UMLS CUI [5,1])
C1516048 (UMLS CUI [5,2])
C0034378 (UMLS CUI [5,3])
C3897601 (UMLS CUI [5,4])
C0013856 (UMLS CUI [5,5])
C0752046 (UMLS CUI [6,1])
C1707455 (UMLS CUI [6,2])
C0750484 (UMLS CUI [6,3])
C0596130 (UMLS CUI [6,4])
C0445247 (UMLS CUI [6,5])
C0237401 (UMLS CUI [6,6])
C1298908 (UMLS CUI [6,7])
C5552996 (UMLS CUI [6,8])
C5414521 (UMLS CUI [7,1])
C0750484 (UMLS CUI [7,2])
C1511518 (UMLS CUI [7,3])
C0025202 (UMLS CUI [7,4])
C0475358 (UMLS CUI [7,5])
C5414521 (UMLS CUI [8,1])
C0750484 (UMLS CUI [8,2])
C1707513 (UMLS CUI [8,3])
C0205307 (UMLS CUI [8,4])
C2347026 (UMLS CUI [8,5])