Eligibility Criteria

Inclusion and exclusion criteria
Description

Inclusion and exclusion criteria

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1512693
The following eligibility criteria were evaluated during screening.
Description

Elig.phs000430.v1.p1.1

Data type

boolean

Alias
UMLS CUI [1,1]
C3846158
*Inclusion*
Description

Elig.phs000430.v1.p1.2

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
A history of chronic HCV
Description

Elig.phs000430.v1.p1.3

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C3872662
Failure to achieve a virologic or biochemical response during previous interferon therapy (with or without ribavirin)
Description

Elig.phs000430.v1.p1.4

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C3872662
UMLS CUI [1,3]
C0279030
UMLS CUI [1,4]
C0162643
An elevation in serum AST or ALT within 6 months of enrollment
Description

Elig.phs000430.v1.p1.5

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C4746878
UMLS CUI [1,3]
C0332285
UMLS CUI [1,4]
C4071833
UMLS CUI [1,5]
C1516879
UMLS CUI [2,1]
C1512693
UMLS CUI [2,2]
C4313265
UMLS CUI [2,3]
C0332285
UMLS CUI [2,4]
C4071833
UMLS CUI [2,5]
C1516879
At least stage 3 fibrosis on liver biopsy by the Ishak scoring system
Description

Elig.phs000430.v1.p1.6

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C1524031
UMLS CUI [1,3]
C2986949
An age of 18 years or greater
Description

Elig.phs000430.v1.p1.7

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0001779
Willingness to utilize adequate contraception when being treated with ribavirin
Description

Elig.phs000430.v1.p1.8

Data type

boolean

Alias
UMLS CUI [1,1]
C1512693
UMLS CUI [1,2]
C0700589
UMLS CUI [1,3]
C2709058
UMLS CUI [1,4]
C0035525
*Exclusion*
Description

Elig.phs000430.v1.p1.9

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
Any other co-existent liver disease
Description

Elig.phs000430.v1.p1.10

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0205394
UMLS CUI [1,3]
C0023895
UMLS CUI [1,4]
C0521115
A Child-Turcotte-Pugh Score of 7 points or greater
Description

Elig.phs000430.v1.p1.11

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C3854424
A history of ascites, hepatic encephalopathy or variceal hemorrhage
Description

Elig.phs000430.v1.p1.12

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0262926
UMLS CUI [1,3]
C0003962
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0262926
UMLS CUI [2,3]
C0085584
UMLS CUI [3,1]
C0680251
UMLS CUI [3,2]
C0262926
UMLS CUI [3,3]
C0333106
A platelet count < 75,000, PMN count < 1,500 or Hct < 33%
Description

Elig.phs000430.v1.p1.13

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0032181
UMLS CUI [1,3]
C0205216
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0518014
UMLS CUI [2,3]
C0205216
UMLS CUI [3,1]
C0680251
UMLS CUI [3,2]
C0857490
UMLS CUI [3,3]
C0205216
An AFP > 200 ng/ml or the presence of a hepatic mass suggestive of HCC
Description

Elig.phs000430.v1.p1.14

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0235971
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C2239176
UMLS CUI [2,3]
C0750491
A bilirubin > 2.5 mg/dl (except for patients with Gilbert's syndrome)
Description

Elig.phs000430.v1.p1.15

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0311468
UMLS CUI [1,3]
C0332300
UMLS CUI [1,4]
C0017551
A serum creatinine > 1.5 mg/dl
Description

Elig.phs000430.v1.p1.16

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0700225
Co-infection with HIV
Description

Elig.phs000430.v1.p1.17

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C4062778
Poorly controlled diabetes mellitus
Description

Elig.phs000430.v1.p1.18

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0554876
Another serious medical disorder
Description

Elig.phs000430.v1.p1.19

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C3843040
UMLS CUI [1,3]
C0205404
A serious psychiatric disorder
Description

Elig.phs000430.v1.p1.20

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C3841614
A history of alcohol abuse within the past year
Description

Elig.phs000430.v1.p1.21

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0085762
UMLS CUI [1,3]
C3887293
The use of illicit drugs within the past two years
Description

Elig.phs000430.v1.p1.22

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0281875
UMLS CUI [1,3]
C1444637
UMLS CUI [1,4]
C4299034
Intolerance to previous interferon treatment
Description

Elig.phs000430.v1.p1.23

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0205156
UMLS CUI [1,3]
C0279030
UMLS CUI [1,4]
C1744706
Inability to provide informed consent
Description

Elig.phs000430.v1.p1.24

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0021430
UMLS CUI [1,3]
C1299582
Pregnancy, breast feeding, or the male partner of a pregnant woman
Description

Elig.phs000430.v1.p1.25

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C0032961
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0006147
UMLS CUI [3,1]
C0680251
UMLS CUI [3,2]
C0919624
Inability or unwillingness to undergo liver biopsy
Description

Elig.phs000430.v1.p1.26

Data type

boolean

Alias
UMLS CUI [1,1]
C0680251
UMLS CUI [1,2]
C1299582
UMLS CUI [1,3]
C0193388
UMLS CUI [2,1]
C0680251
UMLS CUI [2,2]
C0558080
UMLS CUI [2,3]
C0193388

Similar models

Eligibility Criteria

Name
Type
Description | Question | Decode (Coded Value)
Data type
Alias
Item Group
Inclusion and exclusion criteria
C0680251 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Elig.phs000430.v1.p1.1
Item
The following eligibility criteria were evaluated during screening.
boolean
C3846158 (UMLS CUI [1,1])
Elig.phs000430.v1.p1.2
Item
*Inclusion*
boolean
C1512693 (UMLS CUI [1,1])
Elig.phs000430.v1.p1.3
Item
A history of chronic HCV
boolean
C1512693 (UMLS CUI [1,1])
C3872662 (UMLS CUI [1,2])
Elig.phs000430.v1.p1.4
Item
Failure to achieve a virologic or biochemical response during previous interferon therapy (with or without ribavirin)
boolean
C1512693 (UMLS CUI [1,1])
C3872662 (UMLS CUI [1,2])
C0279030 (UMLS CUI [1,3])
C0162643 (UMLS CUI [1,4])
Elig.phs000430.v1.p1.5
Item
An elevation in serum AST or ALT within 6 months of enrollment
boolean
C1512693 (UMLS CUI [1,1])
C4746878 (UMLS CUI [1,2])
C0332285 (UMLS CUI [1,3])
C4071833 (UMLS CUI [1,4])
C1516879 (UMLS CUI [1,5])
C1512693 (UMLS CUI [2,1])
C4313265 (UMLS CUI [2,2])
C0332285 (UMLS CUI [2,3])
C4071833 (UMLS CUI [2,4])
C1516879 (UMLS CUI [2,5])
Elig.phs000430.v1.p1.6
Item
At least stage 3 fibrosis on liver biopsy by the Ishak scoring system
boolean
C1512693 (UMLS CUI [1,1])
C1524031 (UMLS CUI [1,2])
C2986949 (UMLS CUI [1,3])
Elig.phs000430.v1.p1.7
Item
An age of 18 years or greater
boolean
C1512693 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
Elig.phs000430.v1.p1.8
Item
Willingness to utilize adequate contraception when being treated with ribavirin
boolean
C1512693 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C2709058 (UMLS CUI [1,3])
C0035525 (UMLS CUI [1,4])
Elig.phs000430.v1.p1.9
Item
*Exclusion*
boolean
C0680251 (UMLS CUI [1,1])
Elig.phs000430.v1.p1.10
Item
Any other co-existent liver disease
boolean
C0680251 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C0023895 (UMLS CUI [1,3])
C0521115 (UMLS CUI [1,4])
Elig.phs000430.v1.p1.11
Item
A Child-Turcotte-Pugh Score of 7 points or greater
boolean
C0680251 (UMLS CUI [1,1])
C3854424 (UMLS CUI [1,2])
Elig.phs000430.v1.p1.12
Item
A history of ascites, hepatic encephalopathy or variceal hemorrhage
boolean
C0680251 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
C0003962 (UMLS CUI [1,3])
C0680251 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C0085584 (UMLS CUI [2,3])
C0680251 (UMLS CUI [3,1])
C0262926 (UMLS CUI [3,2])
C0333106 (UMLS CUI [3,3])
Elig.phs000430.v1.p1.13
Item
A platelet count < 75,000, PMN count < 1,500 or Hct < 33%
boolean
C0680251 (UMLS CUI [1,1])
C0032181 (UMLS CUI [1,2])
C0205216 (UMLS CUI [1,3])
C0680251 (UMLS CUI [2,1])
C0518014 (UMLS CUI [2,2])
C0205216 (UMLS CUI [2,3])
C0680251 (UMLS CUI [3,1])
C0857490 (UMLS CUI [3,2])
C0205216 (UMLS CUI [3,3])
Elig.phs000430.v1.p1.14
Item
An AFP > 200 ng/ml or the presence of a hepatic mass suggestive of HCC
boolean
C0680251 (UMLS CUI [1,1])
C0235971 (UMLS CUI [1,2])
C0680251 (UMLS CUI [2,1])
C2239176 (UMLS CUI [2,2])
C0750491 (UMLS CUI [2,3])
Elig.phs000430.v1.p1.15
Item
A bilirubin > 2.5 mg/dl (except for patients with Gilbert's syndrome)
boolean
C0680251 (UMLS CUI [1,1])
C0311468 (UMLS CUI [1,2])
C0332300 (UMLS CUI [1,3])
C0017551 (UMLS CUI [1,4])
Elig.phs000430.v1.p1.16
Item
A serum creatinine > 1.5 mg/dl
boolean
C0680251 (UMLS CUI [1,1])
C0700225 (UMLS CUI [1,2])
Elig.phs000430.v1.p1.17
Item
Co-infection with HIV
boolean
C0680251 (UMLS CUI [1,1])
C4062778 (UMLS CUI [1,2])
Elig.phs000430.v1.p1.18
Item
Poorly controlled diabetes mellitus
boolean
C0680251 (UMLS CUI [1,1])
C0554876 (UMLS CUI [1,2])
Elig.phs000430.v1.p1.19
Item
Another serious medical disorder
boolean
C0680251 (UMLS CUI [1,1])
C3843040 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
Elig.phs000430.v1.p1.20
Item
A serious psychiatric disorder
boolean
C0680251 (UMLS CUI [1,1])
C3841614 (UMLS CUI [1,2])
Elig.phs000430.v1.p1.21
Item
A history of alcohol abuse within the past year
boolean
C0680251 (UMLS CUI [1,1])
C0085762 (UMLS CUI [1,2])
C3887293 (UMLS CUI [1,3])
Elig.phs000430.v1.p1.22
Item
The use of illicit drugs within the past two years
boolean
C0680251 (UMLS CUI [1,1])
C0281875 (UMLS CUI [1,2])
C1444637 (UMLS CUI [1,3])
C4299034 (UMLS CUI [1,4])
Elig.phs000430.v1.p1.23
Item
Intolerance to previous interferon treatment
boolean
C0680251 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0279030 (UMLS CUI [1,3])
C1744706 (UMLS CUI [1,4])
Elig.phs000430.v1.p1.24
Item
Inability to provide informed consent
boolean
C0680251 (UMLS CUI [1,1])
C0021430 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
Elig.phs000430.v1.p1.25
Item
Pregnancy, breast feeding, or the male partner of a pregnant woman
boolean
C0680251 (UMLS CUI [1,1])
C0032961 (UMLS CUI [1,2])
C0680251 (UMLS CUI [2,1])
C0006147 (UMLS CUI [2,2])
C0680251 (UMLS CUI [3,1])
C0919624 (UMLS CUI [3,2])
Elig.phs000430.v1.p1.26
Item
Inability or unwillingness to undergo liver biopsy
boolean
C0680251 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0193388 (UMLS CUI [1,3])
C0680251 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])
C0193388 (UMLS CUI [2,3])