Based on the data collected by NACC, the ADGC Neuropathology Core Leaders Subcommittee derived inclusion and exclusion criteria for AD and control samples. All autopsied subjects were age ≥ 60 years at death. AD cases were demented according to DSM-IV criteria or Clinical Dementia Rating (CDR) ≥ 1.
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Based on the data collected by NACC, the ADGC Neuropathology Core Leaders Subcommittee derived inclusion and exclusion criteria for AD and control samples. All autopsied subjects were age ≥ 60 years at death. AD cases were demented according to DSM-IV criteria or Clinical Dementia Rating (CDR) ≥ 1.
boolean
C0002395 (UMLS CUI [1,1])
C0277750 (UMLS CUI [1,2])
C1546180 (UMLS CUI [1,3])
C0002395 (UMLS CUI [2,1])
C4304227 (UMLS CUI [2,2])
C0220952 (UMLS CUI [2,3])
Neuropathologic stratification of cases followed NIA/Reagan criteria explicitly, or used a similar approach when NIA/Reagan criteria were coded as not done, missing, or unknown. Cases were intermediate or high likelihood by NIA/Reagan criteria with moderate to frequent amyloid plaques and neurofibrillary tangle (NFT) Braak stage of III-VI. Persons with Down's syndrome, non-AD tauopathies and synucleinopathies were excluded. All autopsied controls had a clinical evaluation within two years of death. Controls did not meet DSM-IV criteria for dementia, did not have a diagnosis of mild cognitive impairment (MCI), and had a CDR of 0, if performed. Controls were did not meet or were low-likelihood AD by NIA/Reagan criteria, had sparse or no amyloid plaques, and a Braak NFT stage of 0 - II.
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Neuropathologic stratification of cases followed NIA/Reagan criteria explicitly, or used a similar approach when NIA/Reagan criteria were coded as not done, missing, or unknown. Cases were intermediate or high likelihood by NIA/Reagan criteria with moderate to frequent amyloid plaques and neurofibrillary tangle (NFT) Braak stage of III-VI. Persons with Down's syndrome, non-AD tauopathies and synucleinopathies were excluded. All autopsied controls had a clinical evaluation within two years of death. Controls did not meet DSM-IV criteria for dementia, did not have a diagnosis of mild cognitive impairment (MCI), and had a CDR of 0, if performed. Controls were did not meet or were low-likelihood AD by NIA/Reagan criteria, had sparse or no amyloid plaques, and a Braak NFT stage of 0 - II.
boolean
C1706256 (UMLS CUI [1,1])
C0871251 (UMLS CUI [1,2])
C0680251 (UMLS CUI [2,1])
C0949664 (UMLS CUI [2,2])
C0013080 (UMLS CUI [2,3])
C5191670 (UMLS CUI [2,4])
C0009932 (UMLS CUI [3,1])
C4084924 (UMLS CUI [3,2])
C0332152 (UMLS CUI [3,3])
C1306577 (UMLS CUI [3,4])
C0686906 (UMLS CUI [3,5])
C1270972 (UMLS CUI [3,6])
C0451074 (UMLS CUI [3,7])
Common variants at *MS4A4/MS4A6E*, *CD2AP*, *CD33* and *EPHA1* are associated with late-onset Alzheimer's disease.
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[Reprinted from AC Naj et al. Common variants at *MS4A4/MS4A6E*, *CD2AP*, *CD33* and *EPHA1* are associated with late-onset Alzheimer's disease. *Nature Genetics* 43, 436-441 (2011). doi:10.1038/ng.801. PMID: 21460841.]
boolean
C3263354 (UMLS CUI [1,1])