Individuals are considered eligible if the diagnosis of systemic sclerosis is confirmed by meeting the 1980 Preliminary Criteria for the Classification of Systemic Sclerosis OR if 3 of the 5 CREST features are documented to be present by medical record review as outlined below.
Item
Individuals are considered eligible if the diagnosis of systemic sclerosis is confirmed by meeting the 1980 Preliminary Criteria for the Classification of Systemic Sclerosis OR if 3 of the 5 CREST features are documented to be present by medical record review as outlined below.
boolean
C1706256 (UMLS CUI [1,1])
C0036421 (UMLS CUI [1,2])
C0679228 (UMLS CUI [1,3])
*Inclusion Criteria: 1980 Preliminary Criteria for the Classification of Systemic Sclerosis*
Item
*Inclusion Criteria: 1980 Preliminary Criteria for the Classification of Systemic Sclerosis*
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0679228 (UMLS CUI [1,3])
C0036421 (UMLS CUI [1,4])
The American College of Rheumatology (former American Rheumatism Association - ARA) has defined criteria, that are 97% sensitive and 98% specific for systemic sclerosis (SSc) as follows:
Item
The American College of Rheumatology (former American Rheumatism Association - ARA) has defined criteria, that are 97% sensitive and 98% specific for systemic sclerosis (SSc) as follows:
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0035452 (UMLS CUI [1,3])
C0679228 (UMLS CUI [1,4])
*Major criterion:*
Item
*Major criterion:*
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C0243161 (UMLS CUI [1,4])
Skin thickening (skin sclerosis) involving the fingers and extending proximal to the metacarpal phalangeal (MCP) joints.
Item
Skin thickening (skin sclerosis) involving the fingers and extending proximal to the metacarpal phalangeal (MCP) joints.
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
C0243161 (UMLS CUI [1,4])
C0241165 (UMLS CUI [1,5])
C0205107 (UMLS CUI [1,6])
C0025525 (UMLS CUI [1,7])
*Minor criteria:*
Item
*Minor criteria:*
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0205165 (UMLS CUI [1,3])
C0243161 (UMLS CUI [1,4])
Sclerodactyly (skin thickening confined to the fingers and/or toes)
Item
Sclerodactyly (skin thickening confined to the fingers and/or toes)
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0205165 (UMLS CUI [1,3])
C0243161 (UMLS CUI [1,4])
C0150988 (UMLS CUI [1,5])
Digital pitting scars or loss of substance of the digital finger pads (pulp loss)
Item
Digital pitting scars or loss of substance of the digital finger pads (pulp loss)
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0205165 (UMLS CUI [1,3])
C0243161 (UMLS CUI [1,4])
C3854542 (UMLS CUI [1,5])
C1410898 (UMLS CUI [1,6])
C0459764 (UMLS CUI [1,7])
Bilateral basilar pulmonary fibrosis
Item
Bilateral basilar pulmonary fibrosis
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0205165 (UMLS CUI [1,3])
C0243161 (UMLS CUI [1,4])
C0034069 (UMLS CUI [1,5])
C0238767 (UMLS CUI [1,6])
C1184146 (UMLS CUI [1,7])
The patient should fulfill the major criterion or two of the three minor criteria.
Item
The patient should fulfill the major criterion or two of the three minor criteria.
boolean
C1706256 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
C0243161 (UMLS CUI [1,3])
*Subsets of Systemic Sclerosis* Skin involvement Distal and proximal Extremities and/or the trunk Distal to elbows and knees
Item
*Subsets of Systemic Sclerosis* <th></th> <th>Diffuse</th> <th>Limited*</th> Skin involvement Distal and proximal Extremities and/or the trunk Distal to elbows and knees
boolean
C1512693 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0036421 (UMLS CUI [1,3])
C1515010 (UMLS CUI [1,4])
In addition, a diagnosis of systemic sclerosis is considered present if at least 3 out of 5 of the CREST features are present. These include: Calcinosis, Raynaud's phenomenon, esophageal dysmotility, Sclerodactyly and Telangiectasias.
Item
In addition, a diagnosis of systemic sclerosis is considered present if at least 3 out of 5 of the CREST features are present. These include: Calcinosis, Raynaud's phenomenon, esophageal dysmotility, Sclerodactyly and Telangiectasias.
boolean
C1512693 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0036421 (UMLS CUI [1,3])
C0206138 (UMLS CUI [1,4])
C0006663 (UMLS CUI [1,5])
C0034735 (UMLS CUI [1,6])
C0014858 (UMLS CUI [1,7])
C0150988 (UMLS CUI [1,8])
C0039446 (UMLS CUI [1,9])
*Exclusion Criteria:*
Item
*Exclusion Criteria:*
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
<18 years of age
Item
<18 years of age
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
Unable to provide consent
Item
Unable to provide consent
boolean
C0680251 (UMLS CUI [1,1])
C1706256 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C1299582 (UMLS CUI [1,4])