Admission type
Item
Inpatient or Outpatient
boolean
C1550330 (UMLS CUI [1])
Age
Item
Age at least 18 years and not older than 68 years
boolean
C0001779 (UMLS CUI [1])
397669002 (SNOMED CT 2011_0131)
Diagnosis
Item
Primary DSM-IV diagnosis of Depression, single or recurrent episode confirmed by the Structured Clinical Interview for the DSM-IV (SCID-IV), with the additional requirements of a current episode ≥4 weeks and CGI-S ≥4.
boolean
C0011581 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])
C3639708 (UMLS CUI [1,3])
Depression scale
Item
Total hdrs-21 ≥20 and item 1 score ≥2 at the screening visit.
boolean
C2021166 (UMLS CUI [1])
()
Response to antidepressant medication
Item
The patient did not respond to at least one antidepressant medication given for an accepted dose and duration.
boolean
C3844724 (UMLS CUI [1,1])
C0003289 (UMLS CUI [1,2])
Consent
Item
Capable and willing to provide informed consent
boolean
C0021430 (UMLS CUI [1])
Compliance
Item
Able to adhere to the treatment schedule.
boolean
C0525058 (UMLS CUI [1])
Secondary depression
Item
Depression secondary to a general medical condition.
boolean
C0277555 (UMLS CUI [1,1])
C0011581 (UMLS CUI [1,2])
Substance abuse/ dependence
Item
History of substance abuse or dependence within the past 6 month (except opioids, nicotine and caffeine).
boolean
C0038586 (UMLS CUI [1])
Antidepressant medication
Item
All antidepressant medications, must have been in stable dosage for at least 3 weeks prior to entry into the study, with no anticipation of change over the duration of the study.
boolean
C0003289 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Medication
Item
Use of any medication(s) listed on the excluded medication list within the time that mention for each medication on the list.
boolean
C0013227 (UMLS CUI [1])
Psychotic, affective and behavioral disorders
Item
Any psychotic disorder (lifetime), including schizoaffective disorder, or major depression with psychotic features • bipolar disorder • eating disorder
boolean
C0033975 (UMLS CUI [1])
C0005586 (UMLS CUI [2])
C0013473 (UMLS CUI [3])
Contraindication
Item
Subjects who were taking a known contraindication to minocycline treatment.
boolean
C1301624 (UMLS CUI [1,1])
C0026187 (UMLS CUI [1,2])
Pretreatment
Item
Subjects who had received treatment with minocycline or β-lactam antibiotics in the preceding half year before study entry.
boolean
C0026187 (UMLS CUI [1,1])
C0003232 (UMLS CUI [1,2])
Suicidal risk
Item
Present suicidal risk as assessed by the investigator or significant suicide risk based on hdrs-21 item 3 score of 3 or 4 or a history of attempted suicide in the last 6 month
boolean
C0563664 (UMLS CUI [1,1])
C0038663 (UMLS CUI [1,2])
Pregnancy and breastfeeding
Item
Known or suspected pregnancy or women of childbearing potential and not using a medically accepted form of contraception when engaging in sexual intercourse (if using oral contraceptives, during the minocycline treatment, subject should use an additional contraceptives), or women who are breastfeeding
boolean
C2919192 (UMLS CUI [1,1])
C0032961 (UMLS CUI [1,2])
C0006147 (UMLS CUI [1,3])
Hepatic or renal insufficiency
Item
Patients with severe hepatic or renal insufficiency.
boolean
C1306571 (UMLS CUI [1,1])
C1565489 (UMLS CUI [1,2])