Ausschlusskriterien
Pregnant or breast feeding women
boolean
Fertile patients without adequate contraception during therapy
boolean
Past or ongoing drug abuse or alcoholic excess
boolean
Prior chemotherapy
boolean
Prior radiotherapy to the pelvis
boolean
Prior (within 4 weeks) or concurrent treatment with any other investigational agent
boolean
Psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule
boolean
History of severe somatic or psychological diseases: - instable cardiac disease not well controlled with medication, myocardial infarction within the last 6 months:* Central nervous system disorders or psychiatric disability including dementia or epileptic disease. * active uncontrolled intercurrent infections or sepsis
boolean
Peripheral neuropathy > 2 (NCI CTC AE grading)
boolean
Previous or concurrent malignancies, with the exception of adequately treated basal cell carcinoma of the skin or in situ carcinoma of the cervix. The inclusion of patients with other adequately treated tumors within the last 5 years has to be discussed with the principal investigator
boolean
Chronic diarrhea (> NCI CTC AE-Grad 1)
boolean
Known allergy to substances containing platinum compounds
boolean
Concurrent use of the antiviral agent sorivudine or chemically related analogues
boolean
Known deficiency of dehydropyrimidindehydrogenase (DPD)
boolean