Liver carcinoma Advanced phase
Item
advanced stage hepatocellular carcinoma
boolean
C2239176 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
Progressive Disease | Sorafenib
Item
patients exhibiting progressive disease under sorafenib treatment
boolean
C1335499 (UMLS CUI [1])
C1516119 (UMLS CUI [2])
Child-Pugh Classification
Item
child-pugh class a and b. only patients with child-pugh index class b of not more than 7 will be included
boolean
C4050412 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status 0, 1 or 2
boolean
C1520224 (UMLS CUI [1])
First line treatment Sorafenib Dosage U/day
Item
precedent first-line treatment with sorafenib minimum continuous dosing of 400 mg per day for at least 8 weeks
boolean
C1708063 (UMLS CUI [1,1])
C1516119 (UMLS CUI [1,2])
C0178602 (UMLS CUI [1,3])
C0456683 (UMLS CUI [1,4])
Exclusion Criteria Main
Item
main exclusion criteria:
boolean
C0680251 (UMLS CUI [1,1])
C1542147 (UMLS CUI [1,2])
Cancer Other Different Liver carcinoma | Exception Carcinoma in situ of uterine cervix | Exception Basal cell carcinoma Treated | Exception Bladder Neoplasm Superficial TNM clinical staging | Curative treatment Neoplasm allowed
Item
previous or concurrent cancer that is distinct in primary site or histology from hcc, except cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors (ta, tis and t1) - any cancer curatively treated > 3 years prior to entry is permitted
boolean
C1707251 (UMLS CUI [1,1])
C1705242 (UMLS CUI [1,2])
C2239176 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C0851140 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0007117 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0005695 (UMLS CUI [4,2])
C0205124 (UMLS CUI [4,3])
C3258246 (UMLS CUI [4,4])
C1273390 (UMLS CUI [5,1])
C0027651 (UMLS CUI [5,2])
C0683607 (UMLS CUI [5,3])
Kidney Failure Requirement Hemodialysis | Kidney Failure Requirement Peritoneal Dialysis
Item
renal failure requiring hemo- or peritoneal dialysis
boolean
C0035078 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0019004 (UMLS CUI [1,3])
C0035078 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0031139 (UMLS CUI [2,3])
Central Nervous System Neoplasms | Metastatic malignant neoplasm to brain Symptomatic
Item
known central nervous system (cns) tumors including symptomatic brain metastasis
boolean
C0085136 (UMLS CUI [1])
C0220650 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
Child-Pugh Classification | Ascites Grade | Hepatic Encephalopathy Grade
Item
child-pugh index class b in combination with more than slight ascites or hepatic encephalopathy > grade i
boolean
C4050412 (UMLS CUI [1])
C0003962 (UMLS CUI [2,1])
C0441800 (UMLS CUI [2,2])
C0019151 (UMLS CUI [3,1])
C0441800 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
pregnant or breastfeeding women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Intolerance to Sorafenib
Item
sorafenib intolerance
boolean
C1744706 (UMLS CUI [1,1])
C1516119 (UMLS CUI [1,2])
Major surgery
Item
major surgery within the last 4 weeks
boolean
C0679637 (UMLS CUI [1])