Einschlusskriterien
age 18 Years to 70 Years
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adult patients, 18-70 years of age
glioblastoma, confirmed histologically
no previous chemotherapy or radiotherapy for glioblastoma
non-methylated MGMT promoter in the tumor.
Ausschlusskriterien
prior systemic treatment for glioblastoma multiforme
prior treatment with Avastin
significant cardiovascular disease
other active malignant disease.