Age
Item
older than 18 years
boolean
C0001779 (UMLS CUI [1])
Hepatitis B surface antigen positive
Item
hbsag+ at screening and for at least 6 months prior to study entry
boolean
C0149709 (UMLS CUI [1])
Hepatitis B e antigen positive
Item
hbeag+
boolean
C0392390 (UMLS CUI [1])
Hepatitis B DNA Measurement
Item
hbv dna greater than 6 log10 copies/ml
boolean
C3641250 (UMLS CUI [1])
Platelet Count measurement
Item
platelet count greater than 50,000 platelets/mm3
boolean
C0032181 (UMLS CUI [1])
Hemoglobin
Item
hemoglobin greater than 7.5 g/dl
boolean
C0019046 (UMLS CUI [1])
Alanine aminotransferase measurement
Item
alt less than uln
boolean
C0201836 (UMLS CUI [1])
Estimation of creatinine clearance by Cockcroft-Gault formula
Item
estimated creatine clearance>50 ml/min as estimated by the crockcroft-gault equation ((140-age) x (kg)/(serum creatine x 72) (for women x 0.85))
boolean
C2711451 (UMLS CUI [1])
Gender Contraceptive methods | Condoms, Male | Female Condoms | Spermicide | Vaginal contraceptive diaphragm | CERVICAL CAP FOR CONTRACEPTIVE USE | Intrauterine Devices | Hormonal contraception
Item
female and male participants must be practicing an effective form of contraception (male or female condom with spermicide, diaphragm or cervical cap with spermicide, intrauterine device, hormonal contraception)
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0009653 (UMLS CUI [2])
C0221829 (UMLS CUI [3])
C1144908 (UMLS CUI [4])
C0042241 (UMLS CUI [5])
C0493327 (UMLS CUI [6])
C0021900 (UMLS CUI [7])
C2985296 (UMLS CUI [8])
serum alpha-fetoprotein (AFP) measurement
Item
serum alpha-fetoprotein less than 50 ng/ml within 30 days of study entry
boolean
C0546833 (UMLS CUI [1])
Child-Pugh Classification | Ascites | Bleeding varices | Hepatic Encephalopathy
Item
childs-pugh score less than 7 and no ascites, variceal bleeding, or hepatic encephalopathy
boolean
C4050412 (UMLS CUI [1])
C0003962 (UMLS CUI [2])
C0333106 (UMLS CUI [3])
C0019151 (UMLS CUI [4])
Informed Consent | Protocol Compliance
Item
able to give written informed consent and to comply with the study protocol
boolean
C0021430 (UMLS CUI [1])
C0525058 (UMLS CUI [2])
HIV Evidence of | Hepatitis C Evidence of | Hepatitis D Infection Evidence of
Item
history or evidence of hiv, hepatitis c or hepatitis d
boolean
C0019682 (UMLS CUI [1,1])
C0332120 (UMLS CUI [1,2])
C0019196 (UMLS CUI [2,1])
C0332120 (UMLS CUI [2,2])
C0011226 (UMLS CUI [3,1])
C0332120 (UMLS CUI [3,2])
Hypersensitivity adefovir | Hypersensitivity Nucleoside Analogs | Hypersensitivity nucleotide analog
Item
known or suspected hypersensitivity to adefovir or other nucleoside/nucleotide analogs.
boolean
C0020517 (UMLS CUI [1,1])
C0050175 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C1579410 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0597107 (UMLS CUI [3,2])
Renal dysfunction Clinical Significance
Item
history of clinically significant renal dysfunction
boolean
C3279454 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
Illness Interferes with Therapeutic procedure | Mental disorder Interferes with Therapeutic procedure | Illness Interferes with Protocol Compliance | Mental disorder Interferes with Protocol Compliance
Item
any active medical or psychiatric illness that, in the opinion of the investigator, would interfere with subject treatment, assessment, or compliance with the protocol
boolean
C0221423 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
C0004936 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0087111 (UMLS CUI [2,3])
C0221423 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0525058 (UMLS CUI [3,3])
C0004936 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0525058 (UMLS CUI [4,3])
Pregnancy | Breast Feeding
Item
pregnancy or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
systemic steroids
Item
receipt of systemic corticosteroids within 90 days of study entry
boolean
C2825233 (UMLS CUI [1])
Pharmaceutical Preparations Nephrotoxic
Item
receipt of nephrotoxic drugs within 8 weeks prior to study screening or expected use of these agents during the course of the study
boolean
C0013227 (UMLS CUI [1,1])
C1514118 (UMLS CUI [1,2])