Ausschlusskriterien
AML of FAB subtype M3
boolean
Previous induction-type chemotherapy for MDS or AML
boolean
Previous treatment with DAC, 5-azacytidine, VPA or another HDAC inhibitor, or ATRA
boolean
low-dose chemotherapy (e.g.hydroxyurea, cytosine arabinoside, melphalan) within 8 weeks prior to DAC treatment, except for cytoreduction of leukocytosis >50 000/µl according to protocol
boolean
Patients with > 50 000 leukocytes/µl in whom initial cytoreduction according to protocol is ineffective
boolean
Treatment with cytokines within previous 4 weeks
boolean
Concomitant use of any other investigational drug
boolean
Other malignancy that is not in remission (previous chemotherapy for other malignancies is not an exclusion criteria)
boolean
Cardiac insufficiency NYHA IV
boolean
HIV infection
boolean
Other uncontrolled active infection
boolean
Psychiatric disorder that interferes with treatment
boolean