age at least 60 Years
Item
age at least 60 Years
boolean
C0001779 (UMLS CUI 2011AA)
397669002 (SNOMED CT 2011_0131)
Patients older than 60 years with acute myeloid leukemia according to FAB (> 30 % bone marrow blasts) not qualifying for, or not consenting to, standard induction chemotherapy or immediate allografting
Item
Patients older than 60 years with acute myeloid leukemia according to FAB (> 30 % bone marrow blasts) not qualifying for, or not consenting to, standard induction chemotherapy or immediate allografting
boolean
C0023467 (UMLS CUI 2011AA)
91861009 (SNOMED CT 2011_0131)
10000880 (MedDRA 14.1)
C92.0 (ICD-10-CM Version 2010)
205.0 (ICD-9-CM Version 2011)
C0011900 (UMLS CUI 2011AA)
439401001 (SNOMED CT 2011_0131)
MTHU008876 (LOINC Version 232)
C0332290 (UMLS CUI 2011AA)
385433004 (SNOMED CT 2011_0131)
CL421536 (UMLS CUI 2011AA)
C0005953 (UMLS CUI 2011AA)
14016003 (SNOMED CT 2011_0131)
MTHU016536 (LOINC Version 232)
C0368761 (UMLS CUI 2011AA)
312256009 (SNOMED CT 2011_0131)
MTHU005201 (LOINC Version 232)
C1548788 (UMLS CUI 2011AA)
C2828392 (UMLS CUI 2011AA)
C0205263 (UMLS CUI 2011AA)
16404004 (SNOMED CT 2011_0131)
C0392920 (UMLS CUI 2011AA)
150415003 (SNOMED CT 2011_0131)
C0205253 (UMLS CUI 2011AA)
88694003 (SNOMED CT 2011_0131)
C0040739 (UMLS CUI 2011AA)
Life expectancy > 3 months with successful treatment
Item
Life expectancy > 3 months with successful treatment
boolean
C0023671 (UMLS CUI 2011AA)
LP75025-4 (LOINC Version 232)
C0439093 (UMLS CUI 2011AA)
276140008 (SNOMED CT 2011_0131)
GT (HL7 V3 2006_05)
C0205449 (UMLS CUI 2011AA)
421291004 (SNOMED CT 2011_0131)
C0439231 (UMLS CUI 2011AA)
258706009 (SNOMED CT 2011_0131)
MO (HL7 V3 2006_05)
C1272703 (UMLS CUI 2011AA)
385669000 (SNOMED CT 2011_0131)
C0039798 (UMLS CUI 2011AA)
Performance status ECOG 0, 1, 2
Item
Performance status ECOG 0, 1, 2
boolean
C1520224 (UMLS CUI 2011AA)
Age-adjusted normal cardiac, kidney, liver function (creatinine < 1.5 mg/dl unless leukemia-related, total bilirubin < 2.0 of upper normal limits)
Item
Age-adjusted normal cardiac, kidney, liver function (creatinine < 1.5 mg/dl unless leukemia-related, total bilirubin < 2.0 of upper normal limits)
boolean
C0001779 (UMLS CUI 2011AA)
397669002 (SNOMED CT 2011_0131)
C0456081 (UMLS CUI 2011AA)
410617001 (SNOMED CT 2011_0131)
C0205307 (UMLS CUI 2011AA)
17621005 (SNOMED CT 2011_0131)
N (HL7 V3 2006_05)
C0232164 (UMLS CUI 2011AA)
86185002 (SNOMED CT 2011_0131)
C0232804 (UMLS CUI 2011AA)
11953005 (SNOMED CT 2011_0131)
C0232741 (UMLS CUI 2011AA)
79036002 (SNOMED CT 2011_0131)
C0010294 (UMLS CUI 2011AA)
15373003 (SNOMED CT 2011_0131)
10011358 (MedDRA 14.1)
38483-4 (LOINC Version 232)
C0201913 (UMLS CUI 2011AA)
359986008 (SNOMED CT 2011_0131)
10004696 (MedDRA 14.1)
C1519815 (UMLS CUI 2011AA)
Patients with >50 000 leukocytes/µl in whom initial cytoreduction according to protocol is effective
Item
Patients with >50 000 leukocytes/µl in whom initial cytoreduction according to protocol is effective
boolean
C0023516 (UMLS CUI 2011AA)
52501007 (SNOMED CT 2011_0131)
10047955 (MedDRA 14.1)
MTHU001946 (LOINC Version 232)
C0205265 (UMLS CUI 2011AA)
884001 (SNOMED CT 2011_0131)
C0392756 (UMLS CUI 2011AA)
260400001 (SNOMED CT 2011_0131)
C2348563 (UMLS CUI 2011AA)
C0566588 (UMLS CUI 2011AA)
289172004 (SNOMED CT 2011_0131)
C1704419 (UMLS CUI 2011AA)
254648000 (SNOMED CT 2011_0131)
Written informed consent
Item
Written informed consent
boolean
C0021430 (UMLS CUI 2011AA)
AML of FAB subtype M3
Item
AML of FAB subtype M3
boolean
C0023467 (UMLS CUI 2011AA)
91861009 (SNOMED CT 2011_0131)
10000880 (MedDRA 14.1)
C92.0 (ICD-10-CM Version 2010)
205.0 (ICD-9-CM Version 2011)
C0457329 (UMLS CUI 2011AA)
278165002 (SNOMED CT 2011_0131)
Previous induction-type chemotherapy for MDS or AML
Item
Previous induction-type chemotherapy for MDS or AML
boolean
C0205156 (UMLS CUI 2011AA)
9130008 (SNOMED CT 2011_0131)
C0205263 (UMLS CUI 2011AA)
16404004 (SNOMED CT 2011_0131)
C0392920 (UMLS CUI 2011AA)
150415003 (SNOMED CT 2011_0131)
C3463824 (UMLS CUI 2011AA)
128623006 (SNOMED CT 2011_0131)
10028533 (MedDRA 14.1)
D46 (ICD-10-CM Version 2010)
238.75 (ICD-9-CM Version 2011)
E12552 (CTCAE 1105E)
C0023467 (UMLS CUI 2011AA)
91861009 (SNOMED CT 2011_0131)
10000880 (MedDRA 14.1)
C92.0 (ICD-10-CM Version 2010)
205.0 (ICD-9-CM Version 2011)
Previous treatment with DAC, 5-azacytidine, VPA or another HDAC inhibitor, or ATRA
Item
Previous treatment with DAC, 5-azacytidine, VPA or another HDAC inhibitor, or ATRA
boolean
C1514463 (UMLS CUI 2011AA)
C0049065 (UMLS CUI 2011AA)
420517007 (SNOMED CT 2011_0131)
C0004475 (UMLS CUI 2011AA)
412329008 (SNOMED CT 2011_0131)
C0042291 (UMLS CUI 2011AA)
13965000 (SNOMED CT 2011_0131)
MTHU005126 (LOINC Version 232)
C0205394 (UMLS CUI 2011AA)
74964007 (SNOMED CT 2011_0131)
C1512474 (UMLS CUI 2011AA)
423081009 (SNOMED CT 2011_0131)
C0040845 (UMLS CUI 2011AA)
54972005 (SNOMED CT 2011_0131)
low-dose chemotherapy (e.g.hydroxyurea, cytosine arabinoside, melphalan) within 8 weeks prior to DAC treatment, except for cytoreduction of leukocytosis >50 000/µl according to protocol
Item
low-dose chemotherapy (e.g.hydroxyurea, cytosine arabinoside, melphalan) within 8 weeks prior to DAC treatment, except for cytoreduction of leukocytosis >50 000/µl according to protocol
boolean
CL388412 (UMLS CUI 2011AA)
C0020402 (UMLS CUI 2011AA)
56602009 (SNOMED CT 2011_0131)
C0010711 (UMLS CUI 2011AA)
89265009 (SNOMED CT 2011_0131)
C0025241 (UMLS CUI 2011AA)
387297002 (SNOMED CT 2011_0131)
Patients with > 50 000 leukocytes/µl in whom initial cytoreduction according to protocol is ineffective
Item
Patients with > 50 000 leukocytes/µl in whom initial cytoreduction according to protocol is ineffective
boolean
C0023516 (UMLS CUI 2011AA)
52501007 (SNOMED CT 2011_0131)
10047955 (MedDRA 14.1)
MTHU001946 (LOINC Version 232)
C0205265 (UMLS CUI 2011AA)
884001 (SNOMED CT 2011_0131)
C0392756 (UMLS CUI 2011AA)
260400001 (SNOMED CT 2011_0131)
C2348563 (UMLS CUI 2011AA)
C0566588 (UMLS CUI 2011AA)
289172004 (SNOMED CT 2011_0131)
C1518422 (UMLS CUI 2011AA)
C1704419 (UMLS CUI 2011AA)
254648000 (SNOMED CT 2011_0131)
Treatment with cytokines within previous 4 weeks
Item
Treatment with cytokines within previous 4 weeks
boolean
C0039798 (UMLS CUI 2011AA)
C0079189 (UMLS CUI 2011AA)
75777003 (SNOMED CT 2011_0131)
MTHU018469 (LOINC Version 232)
Concomitant use of any other investigational drug
Item
Concomitant use of any other investigational drug
boolean
CL415222 (UMLS CUI 2011AA)
C1524063 (UMLS CUI 2011AA)
260676000 (SNOMED CT 2011_0131)
C0205394 (UMLS CUI 2011AA)
74964007 (SNOMED CT 2011_0131)
C0013230 (UMLS CUI 2011AA)
Other malignancy that is not in remission (previous chemotherapy for other malignancies is not an exclusion criteria)
Item
Other malignancy that is not in remission (previous chemotherapy for other malignancies is not an exclusion criteria)
boolean
C0205394 (UMLS CUI 2011AA)
74964007 (SNOMED CT 2011_0131)
C0006826 (UMLS CUI 2011AA)
363346000 (SNOMED CT 2011_0131)
10028997 (MedDRA 14.1)
MTHU010328 (LOINC Version 232)
C00-C96 (ICD-10-CM Version 2010)
C1518422 (UMLS CUI 2011AA)
C0544452 (UMLS CUI 2011AA)
277022003 (SNOMED CT 2011_0131)
Cardiac insufficiency NYHA IV
Item
Cardiac insufficiency NYHA IV
boolean
C1319796 (UMLS CUI 2011AA)
HIV infection
Item
Human immunodeficiency virus infection
boolean
C0019693 (UMLS CUI 2011AA)
86406008 (SNOMED CT 2011_0131)
10020161 (MedDRA 14.1)
MTHU020829 (LOINC Version 232)
B20 (ICD-10-CM Version 2010)
042 (ICD-9-CM Version 2011)
Other uncontrolled active infection
Item
Other uncontrolled active infection
boolean
C0205394 (UMLS CUI 2011AA)
74964007 (SNOMED CT 2011_0131)
C0205318 (UMLS CUI 2011AA)
19032002 (SNOMED CT 2011_0131)
C0205177 (UMLS CUI 2011AA)
55561003 (SNOMED CT 2011_0131)
C0009450 (UMLS CUI 2011AA)
257551009 (SNOMED CT 2011_0131)
10021789 (MedDRA 14.1)
Psychiatric disorder that interferes with treatment
Item
Psychiatric disorder that interferes with treatment
boolean
C0004936 (UMLS CUI 2011AA)
74732009 (SNOMED CT 2011_0131)
10037174 (MedDRA 14.1)
F99 (ICD-10-CM Version 2010)
290-319.99 (ICD-9-CM Version 2011)
C0521102 (UMLS CUI 2011AA)
78235001 (SNOMED CT 2011_0131)
C0039798 (UMLS CUI 2011AA)