Study Subject Participation Status | Calcification Study Amish | Clinical trial participant Study Subject Relative | Age
Item
participant of amish family calcification study or related to a afcs participant and at least 20 years old.
boolean
C2348568 (UMLS CUI [1])
C1533591 (UMLS CUI [2,1])
C0008972 (UMLS CUI [2,2])
C0238622 (UMLS CUI [2,3])
C1997894 (UMLS CUI [3,1])
C0681850 (UMLS CUI [3,2])
C0080103 (UMLS CUI [3,3])
C0001779 (UMLS CUI [4])
ID.2
Item
excluded for the entire study if the subject-
boolean
Pregnancy | Delivery
Item
1. is currently pregnant; however they will become eligible six months after delivery.
boolean
C0032961 (UMLS CUI [1])
C0011209 (UMLS CUI [2])
Severe Hypertension Requirement Therapeutic procedure | Blood Pressure
Item
2. has severe hypertension (bp > 180/105), making it unethical not to recommend prompt treatment.
boolean
C4013784 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
C0005823 (UMLS CUI [2])
Pharmaceutical Preparations Affecting research results | Pharmaceutical Preparations Discontinuation Unable | Antihypertensive Agents | Adrenergic beta-Antagonists | Calcium Channel Blockers | Angiotensin-Converting Enzyme Inhibitors | Diuretics | Antilipemic agent | Nitrates | Glucocorticoids, Systemic | Adrenergic Agents | Cholinergic Agents | Common Cold Prescription | Antidepressive Agents | Diet Pharmaceutical Preparations | Weight-Loss Agents
Item
3. takes medications that would affect the outcome(s) to be measured and cannot willingly and safely, in the opinion of the treating physician and study physician, discontinue these medications for 1 week prior to protocol initiation. these medications include anti-hypertensive agents (e.g., beta-blockers, calcium channel antagonists, ace inhibitors, and diuretics), lipid lowering agents, nitrates, systemic glucocorticoids, adrenergic or cholinergic-acting agents including cold formulas and antidepressants, and diet/weight loss agents.
boolean
C0013227 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0683954 (UMLS CUI [1,3])
C0013227 (UMLS CUI [2,1])
C0457454 (UMLS CUI [2,2])
C1299582 (UMLS CUI [2,3])
C0003364 (UMLS CUI [3])
C0001645 (UMLS CUI [4])
C0006684 (UMLS CUI [5])
C0003015 (UMLS CUI [6])
C0012798 (UMLS CUI [7])
C0086440 (UMLS CUI [8])
C0028125 (UMLS CUI [9])
C3540777 (UMLS CUI [10])
C0001637 (UMLS CUI [11])
C0242893 (UMLS CUI [12])
C0009443 (UMLS CUI [13,1])
C0033080 (UMLS CUI [13,2])
C0003289 (UMLS CUI [14])
C0012155 (UMLS CUI [15,1])
C0013227 (UMLS CUI [15,2])
C0376606 (UMLS CUI [16])
Vitamins | Vitamins Discontinuation Unwilling
Item
4. is taking vitamins and are unwilling to discontinue their use for at least 1 week prior to study.
boolean
C0042890 (UMLS CUI [1])
C0042890 (UMLS CUI [2,1])
C0457454 (UMLS CUI [2,2])
C0558080 (UMLS CUI [2,3])
Malignant Neoplasms
Item
5. has a coexisting malignancy
boolean
C0006826 (UMLS CUI [1])
Creatinine measurement, serum | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Hematocrit level | Thyroid stimulating hormone measurement
Item
6. has a creatinine greater than 2.0, ast or alt greater than 2 times the upper limit of normal, hct less than 32, or a tsh less than 0.4 or greater than 5.5.
boolean
C0201976 (UMLS CUI [1])
C0201899 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
C0518014 (UMLS CUI [4])
C0202230 (UMLS CUI [5])
Cold pressor test
Item
excluded from the cold pressor test if the subject-
boolean
C0444689 (UMLS CUI [1])
Raynaud Disease | Symptoms Raynaud Disease
Item
1. has raynaud's disease or symptoms
boolean
C0034734 (UMLS CUI [1])
C1457887 (UMLS CUI [2,1])
C0034734 (UMLS CUI [2,2])
High fat Challenge
Item
excluded from the high fat challenge if the subject-
boolean
C0453819 (UMLS CUI [1,1])
C0805586 (UMLS CUI [1,2])
Malabsorption Syndrome | Lactose Intolerance
Item
1. has a malabsorption disorder or lactose intolerance
boolean
C0024523 (UMLS CUI [1])
C0022951 (UMLS CUI [2])
Gall Bladder Diseases Symptoms | Pancreatitis
Item
2. has symptoms of gall bladder disease or history of pancreatitis
boolean
C0016977 (UMLS CUI [1,1])
C1457887 (UMLS CUI [1,2])
C0030305 (UMLS CUI [2])
Dietary salt intake
Item
excluded from the dietary salt intervention if the subject-
boolean
C0425431 (UMLS CUI [1])
Congestive heart failure | New York Heart Association Classification
Item
1. has stage iii or greater congestive heart failure
boolean
C0018802 (UMLS CUI [1])
C1275491 (UMLS CUI [2])
Food Allergy Diet Food
Item
2. has food allergies to foods included in the diet
boolean
C0016470 (UMLS CUI [1,1])
C0012155 (UMLS CUI [1,2])
C0016452 (UMLS CUI [1,3])
Aspirin Therapeutic procedure
Item
excluded from the aspirin intervention if the subject-
boolean
C0004057 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
Blood Coagulation Disorder | Gastrointestinal Hemorrhage
Item
1. has a bleeding disorder or history of gastrointestinal bleeding
boolean
C0005779 (UMLS CUI [1])
C0017181 (UMLS CUI [2])
Blood Pressure
Item
2. has a blood pressure greater than 160/95
boolean
C0005823 (UMLS CUI [1])
Aspirin | Condition Aspirin Withdrawal Risk Increased | Angina, Unstable | Myocardial Infarction | Angioplasty | Placement of stent | Coronary Artery Bypass Surgery | Atrial Fibrillation | Cerebrovascular accident | Transient Ischemic Attack | Diabetes Mellitus, Non-Insulin-Dependent | Deep Vein Thrombosis | Thrombosis
Item
3. is currently taking aspirin and have conditions that might place them at increased risk from aspirin withdrawal 14 days prior to protocol initiation, including history of unstable angina, mi, angioplasty (including stent placement), coronary artery bypass surgery, atrial fibrillation, stroke or transient ischemic attacks, type 2 diabetes, or deep vein thrombosis or other thrombosis
boolean
C0004057 (UMLS CUI [1])
C0348080 (UMLS CUI [2,1])
C0004057 (UMLS CUI [2,2])
C2349954 (UMLS CUI [2,3])
C0035647 (UMLS CUI [2,4])
C0205217 (UMLS CUI [2,5])
C0002965 (UMLS CUI [3])
C0027051 (UMLS CUI [4])
C0162577 (UMLS CUI [5])
C0522776 (UMLS CUI [6])
C0010055 (UMLS CUI [7])
C0004238 (UMLS CUI [8])
C0038454 (UMLS CUI [9])
C0007787 (UMLS CUI [10])
C0011860 (UMLS CUI [11])
C0149871 (UMLS CUI [12])
C0040053 (UMLS CUI [13])
Polycythemia | Thrombocytosis | Platelet Count measurement
Item
4. has polycythemia, or thrombocytosis (platelet count greater than 500,000)
boolean
C0032461 (UMLS CUI [1])
C0836924 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
Thrombocytopenia | Platelet Count measurement
Item
5. has thrombocytopenia (platelet count less than 75,000)
boolean
C0040034 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
Operative Surgical Procedures
Item
6. has had surgery within the last 6 months
boolean
C0543467 (UMLS CUI [1])
Aspirin allergy
Item
7. has an aspirin allergy
boolean
C0004058 (UMLS CUI [1])
Breast Feeding
Item
8. is currently breast feeding
boolean
C0006147 (UMLS CUI [1])
Collagen induced platelet aggregation | Aggregation | Arachidonic Acid
Item
9. aggregation with collagen 5 micrograms/ml is less than 7 ohms or greater than 31 ohms, or no aggregation at baseline with arachadonic acid
boolean
C0369863 (UMLS CUI [1])
C0332621 (UMLS CUI [2])
C0003695 (UMLS CUI [3])