nsclc and histology
Item
histologically confirmed non-small cell lung cancer of the following histologies: squamous cell carcinoma, adenocarcinoma, large cell carcinoma, no mixed small/non-small cell carcinoma with predominant small cell component.
boolean
C0007131 (UMLS CUI [1])
C0149782 (UMLS CUI [2])
C0152013 (UMLS CUI [3])
C0345958 (UMLS CUI [4])
unresectable tumor stage
Item
unresectable stage iiia/b disease confined to thorax including:
boolean
C1300072 (UMLS CUI [1,1])
C1519810 (UMLS CUI [1,2])
microscopic disease
Item
microscopic disease involvement following attempted surgery and limited to anatomic areas corresponding to stage iii disease (n2-3, t3-4).
boolean
C0278939 (UMLS CUI [1])
C1300072 (UMLS CUI [2])
surgery, relapse, tumor stage
Item
surgically treated stage i/ii disease with histologic or cytologic proof of relapse and limited to anatomic areas corresponding to stage iii disease (n2-3, t3-4).
boolean
C0038894 (UMLS CUI [1])
C0277556 (UMLS CUI [2])
C1300072 (UMLS CUI [3])
tumor stage and extension
Item
t3, n0 tumor extending directly to the chest wall considered resectable and not eligible.
boolean
C1300072 | C1300504 (UMLS CUI [1])
tumor stage, pleural effusion
Item
no stage iiib disease with pleural effusion visible on chest x-ray unless related to a previous thoracotomy.
boolean
C1300072 (UMLS CUI [1,1])
| C0032227 (UMLS CUI [1,2])
carcinoid or mesothelioma
Item
no typical carcinoid or mesothelioma.
boolean
C0007095 (UMLS CUI [1])
C0025500 (UMLS CUI [2])
measurable disease
Item
measurable disease preferred but not required.
boolean
C1513041 (UMLS CUI [1])
prior chemotherapy, radiotherapy
Item
no prior chemotherapy or thoracic radiotherapy.
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
Age
Item
age: 18 and over.
boolean
C0001779 (UMLS CUI [1])
ecog
Item
performance status: ecog 0-2.
boolean
C1520224 (UMLS CUI [1])
granulocyte count
Item
agc greater than 2,000.
boolean
C0857490 (UMLS CUI [1])
platelets
Item
platelets greater than 100,000.
boolean
C0005821 (UMLS CUI [1])
bilirubin
Item
hepatic: bilirubin no greater than 1.5 mg/dl.
boolean
C1278039 (UMLS CUI [1])
creatinine
Item
renal: creatinine no greater than 1.5 mg/dl.
boolean
C0201976 (UMLS CUI [1])
heart diseases
Item
no symptomatic heart disease including: less than fully compensated congestive cardiac failure, significant arrhythmias e.g.: greater than first-degree heart block, uncontrolled and symptomatic atrial dysrhythmia except sinus, bradycardia or sustained ventricular tachycardia, myocardial infarction within 3 months.
boolean
C0018799 (UMLS CUI [1])
C0018802 (UMLS CUI [2])
C0003811 (UMLS CUI [3])
C0006384 (UMLS CUI [4,1])
C0085611 (UMLS CUI [4,2])
C0027051 (UMLS CUI [4,3])
pulmonary infection
Item
pulmonary: no major uncontrolled active infection (unless due to obstructed bronchus).
boolean
C0876973 (UMLS CUI [1])
mental disorders, psychotropic medication
Item
no major active psychiatric problem requiring hospitalization or psychotropic medication such as phenothiazines.
boolean
C0004936 (UMLS CUI [1])
C0033978 (UMLS CUI [2])
Malignant Neoplasms, exceptions
Item
no prior second malignancy within 5 years except: nonmelanomatous skin cancer, in situ carcinoma of the cervix.
boolean
C0006826 (UMLS CUI [1])
C0007114 (UMLS CUI [2])
C0302592 (UMLS CUI [3,1])
C0007099 (UMLS CUI [3,2])
pregnancy, nursing
Item
no pregnant or nursing women.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])