Age
Item
at least 40 years of age
boolean
C0001779 (UMLS CUI [1])
Primary osteoarthritis of knee
Item
primary oa of the knee according to the acr criteria
boolean
C2893931 (UMLS CUI [1])
Osteoarthritis Kellgren-Lawrence score
Item
oa of radiological stages ii or iii according to kellgren and lawrence
boolean
C0029408 (UMLS CUI [1,1])
C3177117 (UMLS CUI [1,2])
Knee pain Moderate | Knee pain Severe
Item
patients with moderate-severe knee pain
boolean
C0231749 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C0231749 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
Malignant Neoplasm Type Any | History of malignant neoplasm
Item
subjects with active malignancy of any type or history of a malignancy within the last five years
boolean
C0006826 (UMLS CUI [1,1])
C0332307 (UMLS CUI [1,2])
C1552551 (UMLS CUI [1,3])
C0455471 (UMLS CUI [2])
Arthritis Interferes with Evaluation | Chondrocalcinosis | Paget's disease Target Knee | Rheumatoid Arthritis | Aseptic osteonecrosis | Gout | Arthritis, Infectious | Ochronosis | Acromegaly | Hemochromatosis | Wilson's disease | Osteochondromatosis | Spondyloarthropathy Seronegative | Mixed Connective Tissue Disease | Collagen-vascular disease | Psoriasis | Inflammatory Bowel Disease
Item
concurrent arthritic disease (antecedents and/or current signs) that could confound or interfere with the evaluation of pain efficacy such as chondrocalcinosis, paget's disease of the ipsilateral limb to the target knee, rheumatoid arthritis, aseptic osteonecrosis, gout, septic arthritis, ochronosis, acromegaly, haemochromatosis, wilson's disease, osteochondromatosis seronegative spondylo-arthropathy, mixed connective tissue disease, collagen vascular disease, psoriasis, inflammatory bowel disease
boolean
C0003864 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0220825 (UMLS CUI [1,3])
C0553730 (UMLS CUI [2])
C0029401 (UMLS CUI [3,1])
C1521840 (UMLS CUI [3,2])
C0022742 (UMLS CUI [3,3])
C0003873 (UMLS CUI [4])
C0391980 (UMLS CUI [5])
C0018099 (UMLS CUI [6])
C0003869 (UMLS CUI [7])
C0028817 (UMLS CUI [8])
C0001206 (UMLS CUI [9])
C0018995 (UMLS CUI [10])
C0019202 (UMLS CUI [11])
C0206641 (UMLS CUI [12])
C0949691 (UMLS CUI [13,1])
C0521144 (UMLS CUI [13,2])
C0026272 (UMLS CUI [14])
C0262428 (UMLS CUI [15])
C0033860 (UMLS CUI [16])
C0021390 (UMLS CUI [17])
Pain Interferes with Evaluation Joint
Item
pain in other parts of the body greater than the knee pain that could interfere with the evaluation of the index joint
boolean
C0030193 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C1261322 (UMLS CUI [1,3])
C0022417 (UMLS CUI [1,4])
Fibromyalgia
Item
patients with fibromyalgia
boolean
C0016053 (UMLS CUI [1])
Myocardial Infarction | Cerebrovascular accident | Chest Pain Relationship Heart Disease | Heart Diseases Serious
Item
subjects with a history of heart attack or stroke, or who have experienced chest pain related to heart disease, or who have had serious diseases of the heart
boolean
C0027051 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0008031 (UMLS CUI [3,1])
C0439849 (UMLS CUI [3,2])
C0018799 (UMLS CUI [3,3])
C0018799 (UMLS CUI [4,1])
C0205404 (UMLS CUI [4,2])
High risk of Cardiovascular event
Item
subjects with high risk of cv events
boolean
C0332167 (UMLS CUI [1,1])
C1320716 (UMLS CUI [1,2])
Communicable Diseases Requirement Antibiotics | Chronic infectious disease Requirement Antibiotics | Virus Diseases Serious | Hepatitis | Herpes zoster | HIV Seropositivity | Mycoses Serious
Item
subjects with any active acute or chronic infections requiring antimicrobial therapy, or serious viral (e.g., hepatitis, herpes zoster, hiv positivity) or fungal infections
boolean
C0009450 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0003232 (UMLS CUI [1,3])
C0151317 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0003232 (UMLS CUI [2,3])
C0042769 (UMLS CUI [3,1])
C0205404 (UMLS CUI [3,2])
C0019158 (UMLS CUI [4])
C0019360 (UMLS CUI [5])
C0019699 (UMLS CUI [6])
C0026946 (UMLS CUI [7,1])
C0205404 (UMLS CUI [7,2])
Recurrent ulcer Upper Gastrointestinal Tract | Inflammatory Bowel Disease | Crohn Disease | Ulcerative Colitis | Coagulation Defects
Item
subjects with a history of recurrent ugi ulceration or active inflammatory bowel disease (e.g., crohn's disease or ulcerative colitis), a significant coagulation defect
boolean
C0333294 (UMLS CUI [1,1])
C3203348 (UMLS CUI [1,2])
C0021390 (UMLS CUI [2])
C0010346 (UMLS CUI [3])
C0009324 (UMLS CUI [4])
C0005779 (UMLS CUI [5])
Ulcer of esophagus | Gastric ulcer | Prepyloric ulcer | Duodenal Ulcer
Item
subjects who have been diagnosed as having or have been treated for oesophageal, gastric, pyloric channel, or duodenal ulceration within 30 days prior to receiving the first dose of study medication
boolean
C0151970 (UMLS CUI [1])
C0038358 (UMLS CUI [2])
C0267116 (UMLS CUI [3])
C0013295 (UMLS CUI [4])
Washout Period Treatment Osteoarthritis
Item
washout period for oa treatments before begginning the study.
boolean
C1710661 (UMLS CUI [1,1])
C0087111 (UMLS CUI [1,2])
C0029408 (UMLS CUI [1,3])