Age
Item
male or female subjects ≥ 20 years old
boolean
C0001779 (UMLS CUI [1])
Parkinson Disease | UPDRS - Modified Hoehn and Yahr Staging | Motor fluctuations Absent | Dyskinetic syndrome | Motor symptoms Stable
Item
subjects diagnosed with idiopathic parkinson's disease (according to the united kingdom parkinson's disease society brain bank diagnostic criteria for parkinson's disease) at modified hoehn and yahr scale stages i-iii; do not have motor fluctuations, dyskinesia, and have stable motor symptom at least 4 weeks prior to the screening visit as judged by the local investigator
boolean
C0030567 (UMLS CUI [1])
C3639878 (UMLS CUI [2])
C1868976 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0013384 (UMLS CUI [4])
C0426980 (UMLS CUI [5,1])
C0205360 (UMLS CUI [5,2])
Hamilton rating scale for depression
Item
subject has a hamilton depression scale (ham- d) score ≥ 16 as evidenced by depression rating scale study in parkinson's disease (schrag a et al, 2007)
boolean
C0451203 (UMLS CUI [1])
Mini-mental state examination
Item
subject has a mini-mental state examination (mmse) score ≥ 24
boolean
C0451306 (UMLS CUI [1])
Levodopa | Levodopa Derivative | Monoamine Oxidase Inhibitors | Anticholinergic Agents | Catechol-O-methyltransferase inhibitor | NMDA Receptor Antagonists
Item
if subject is taking levodopa (l-dopa) and derivatives, monoamine oxidase (mao) b-inhibitors, anticholinergics agents, catechol-o-methyl transferase (comt) inhibitor or n-methyl-d-aspartate (nmda) antagonist, he/she must have been on stable dose for at least 28 days prior to the screening visit
boolean
C0023570 (UMLS CUI [1])
C0023570 (UMLS CUI [2,1])
C1527240 (UMLS CUI [2,2])
C0026457 (UMLS CUI [3])
C0242896 (UMLS CUI [4])
C0595267 (UMLS CUI [5])
C2916808 (UMLS CUI [6])
Antidepressive Agents | Selective Serotonin Reuptake Inhibitors | Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) | Bupropion | Tricyclic Antidepressive Agents
Item
if subject is taking an antidepressant drug such as selective serotonin reuptake inhibitors (ssris), serotonin-norepinephrine reuptake inhibitors (snris), bupropion, tricyclic antidepressants (tcas), he/she must have been on a stable dose for at least 28 days prior to the screening visit and be maintained on that dose for the duration of the trial
boolean
C0003289 (UMLS CUI [1])
C0360105 (UMLS CUI [2])
C1579361 (UMLS CUI [3])
C0085208 (UMLS CUI [4])
C0003290 (UMLS CUI [5])
Medical condition At risk Study Subject Participation Status | Mental condition At risk Study Subject Participation Status | Medical condition Impairing Study Subject Participation Status | Mental condition Impairing Study Subject Participation Status | Bipolar Disorder | Dementia | Hallucinations | Psychotic Disorders
Item
subject has any medical or psychiatric condition (ie, bipolar disorder, dementia, hallucinations or psychosis) that, in the opinion of the investigator, could jeopardize or would compromise the subject's ability to participate in this study
boolean
C3843040 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
C3840291 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C2348568 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0221099 (UMLS CUI [3,2])
C2348568 (UMLS CUI [3,3])
C3840291 (UMLS CUI [4,1])
C0221099 (UMLS CUI [4,2])
C2348568 (UMLS CUI [4,3])
C0005586 (UMLS CUI [5])
C0497327 (UMLS CUI [6])
C0018524 (UMLS CUI [7])
C0033975 (UMLS CUI [8])
History of attempted suicide Lifetime | Suicide attempt | Suicide attempt Interrupted | Feeling suicidal Columbia-Suicide Severity Rating Scale Screening Questionnaire
Item
subject has a lifetime history of suicide attempt (including an active attempt, interrupted attempt, or aborted attempt), or has suicidal ideation in the past 6 months as indicated by a positive response ('yes') to either question 4 or question 5 of the c-ssrs at screening (visit 1)
boolean
C0455507 (UMLS CUI [1,1])
C4071830 (UMLS CUI [1,2])
C0038663 (UMLS CUI [2])
C0038663 (UMLS CUI [3,1])
C1512900 (UMLS CUI [3,2])
C0424000 (UMLS CUI [4,1])
C3827015 (UMLS CUI [4,2])
Psychotherapy | Behavior Therapy
Item
current psychotherapy or behavior therapy while participating in this study
boolean
C0033968 (UMLS CUI [1])
C0004933 (UMLS CUI [2])
Electroconvulsive Therapy
Item
subject has received electroconvulsive therapy within 12 weeks of the screening visit
boolean
C0013806 (UMLS CUI [1])
Dopamine Agonists
Item
subject who has received dopamine agonists within 28 days of the screening visit
boolean
C0178601 (UMLS CUI [1])
Antipsychotic Agents | Methylphenidate | Reserpine | Methyldopa | Metoclopramide | levosulpiride | Amphetamine Derivative
Item
subject who has received neuroleptics, methylphenidate, reserpine, alpha-methyldopa, metoclopramide, levosulpiride or amphetamine derivatives within 28 days of the screening visit
boolean
C0040615 (UMLS CUI [1])
C0025810 (UMLS CUI [2])
C0035179 (UMLS CUI [3])
C0025741 (UMLS CUI [4])
C0025853 (UMLS CUI [5])
C0210380 (UMLS CUI [6])
C0002658 (UMLS CUI [7,1])
C1527240 (UMLS CUI [7,2])