Age
Item
greater than 18 and less than 80 years of age;
boolean
C0001779 (UMLS CUI [1])
Pharmacotherapy Stable
Item
on stable medication regimen
boolean
C0013216 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Antihypertensive Agents Quantity Maximum Tolerated Dose | Antihypertensive Agents Class Different | Diuretics Quantity | Diuretic unchanged
Item
full-tolerated doses of 3 or more antihypertensive medications of different classes, one of which must be a diuretic (with no changes for a minimum of two weeks prior to screening) that is expected to be maintained without changes for at least 3 months.
boolean
C0003364 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0752079 (UMLS CUI [1,3])
C0003364 (UMLS CUI [2,1])
C0456387 (UMLS CUI [2,2])
C1705242 (UMLS CUI [2,3])
C0012798 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0012798 (UMLS CUI [4,1])
C0442739 (UMLS CUI [4,2])
Study procedures Performed
Item
the individual agrees to have all study procedures performed
boolean
C2348563 (UMLS CUI [1,1])
C0184661 (UMLS CUI [1,2])
C0884358 (UMLS CUI [1,3])
Informed Consent
Item
willing to provide written consent
boolean
C0021430 (UMLS CUI [1])
Exclusion Criteria
Item
exclusion
boolean
C0680251 (UMLS CUI [1])
GFR estimation by MDRD
Item
egfr of < 45ml/min/1.73m2, using the mdrd calculation.
boolean
C2170215 (UMLS CUI [1])
Hospitalization Quantity Hypertensive disease
Item
more than one in-patient hospitalization for an antihypertensive crisis within the year.
boolean
C0019993 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0020538 (UMLS CUI [1,3])
Episode Quantity Orthostatic Hypotension | Standing systolic blood pressure Reduced | Standing diastolic blood pressure Reduced
Item
more than one episode(s) of orthostatic hypotension (reduction of sbp of ≥ 20mmhg of diastolic blood pressure (dbp) of ≥ 10mmhg within 3 minutes of standing).
boolean
C0332189 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0020651 (UMLS CUI [1,3])
C1303018 (UMLS CUI [2,1])
C0392756 (UMLS CUI [2,2])
C1303019 (UMLS CUI [3,1])
C0392756 (UMLS CUI [3,2])
Minocycline allergy | Tetracycline allergy | Medical contraindication Minocycline | Medical contraindication Tetracycline
Item
known hypersensitivity or contraindication to minocycline or other tetracycline.
boolean
C0571498 (UMLS CUI [1])
C0039645 (UMLS CUI [2])
C1301624 (UMLS CUI [3,1])
C0026187 (UMLS CUI [3,2])
C1301624 (UMLS CUI [4,1])
C0039644 (UMLS CUI [4,2])
Alcoholic Intoxication, Chronic | Drug abuse
Item
evidence of alcoholism or drug abuse;
boolean
C0001973 (UMLS CUI [1])
C0013146 (UMLS CUI [2])
Comorbidity Severe | Neoplasms | HIV Seropositivity | AIDS
Item
concurrent severe disease (such as neoplasm or hiv positive or aids).
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0027651 (UMLS CUI [2])
C0019699 (UMLS CUI [3])
C0001175 (UMLS CUI [4])
Childbearing Potential
Item
women of childbearing potential
boolean
C3831118 (UMLS CUI [1])