Essential Hypertension Untreated | Essential Hypertension | Antihypertensive therapy | Combined Modality Therapy
Item
patients with essential hypertension, untreated or currently taking antihypertensive therapy (monotherapy or combination therapy).
boolean
C0085580 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0085580 (UMLS CUI [2])
C0585941 (UMLS CUI [3])
C0009429 (UMLS CUI [4])
Blood pressure determination | Randomization Visit | Visit preceding
Item
patients with an office bp ≥ 140/90 mmhg and < 180/110mmhg at the randomization visit and the preceding visit
boolean
C0005824 (UMLS CUI [1])
C0034656 (UMLS CUI [2,1])
C1512346 (UMLS CUI [2,2])
C1512346 (UMLS CUI [3,1])
C0332152 (UMLS CUI [3,2])
Sitting systolic blood pressure mean | Sitting diastolic blood pressure mean | Difference Absolute | Randomization Visit | Visit preceding
Item
patients must have an absolute difference of ≤ 10 mmhg in both their mssbp and their msdbp between the randomization visit and the preceding visit
boolean
C1319893 (UMLS CUI [1,1])
C0444504 (UMLS CUI [1,2])
C1319894 (UMLS CUI [2,1])
C0444504 (UMLS CUI [2,2])
C1705242 (UMLS CUI [3,1])
C0205344 (UMLS CUI [3,2])
C0034656 (UMLS CUI [4,1])
C1512346 (UMLS CUI [4,2])
C1512346 (UMLS CUI [5,1])
C0332152 (UMLS CUI [5,2])
Malignant Hypertension | Severe Hypertension Grade WHO classification | Sitting systolic blood pressure mean
Item
malignant hypertension or severe hypertension (grade 3 of who classification; mssbp
boolean
C0020540 (UMLS CUI [1])
C4013784 (UMLS CUI [2,1])
C0441800 (UMLS CUI [2,2])
C4267671 (UMLS CUI [2,3])
C1319893 (UMLS CUI [3,1])
C0444504 (UMLS CUI [3,2])
Sitting diastolic blood pressure mean
Item
≥180 mmhg or msdbp ≥110 mmhg)
boolean
C1319894 (UMLS CUI [1,1])
C0444504 (UMLS CUI [1,2])
Secondary hypertension | Parenchymal renal hypertension | Hypertension, Renovascular | Aortic coarctation | Conn Syndrome | Cushing's disease | Hypertension secondary to drug | Unilateral renal artery stenosis | Bilateral renal artery stenosis | Pheochromocytoma | Polycystic Kidney Diseases
Item
history or evidence of a secondary form of hypertension, such as renal parenchymal hypertension, renovascular hypertension, coarctation of the aorta, primary hyperaldosteronism, cushing's disease, drug-induced hypertension, unilateral or bilateral renal artery stenosis, pheochromocytoma, polycystic kidney disease (pkd).
boolean
C0155616 (UMLS CUI [1])
C0264649 (UMLS CUI [2])
C0020545 (UMLS CUI [3])
C0003492 (UMLS CUI [4])
C1384514 (UMLS CUI [5])
C0221406 (UMLS CUI [6])
C0581373 (UMLS CUI [7])
C0856759 (UMLS CUI [8])
C0856760 (UMLS CUI [9])
C0031511 (UMLS CUI [10])
C0022680 (UMLS CUI [11])
Diabetes Mellitus, Insulin-Dependent | Diabetes Mellitus, Non-Insulin-Dependent | Hemoglobin A1c measurement Fasting
Item
type 1 or type 2 diabetes mellitus with a fasting glycosylated hemoglobin (hba1c) > 8%
boolean
C0011854 (UMLS CUI [1])
C0011860 (UMLS CUI [2])
C0474680 (UMLS CUI [3,1])
C0015663 (UMLS CUI [3,2])
Renal Insufficiency | Serum creatinine raised | Estimated Glomerular Filtration Rate | Dialysis | Nephrotic Syndrome
Item
evidence of renal impairment as determined by one of the following: serum creatinine >1.5 x uln or egfr < 30 ml/min/1.73m2 at visit 1, a history of dialysis, or a history of nephrotic syndrome
boolean
C1565489 (UMLS CUI [1])
C0700225 (UMLS CUI [2])
C3811844 (UMLS CUI [3])
C0011946 (UMLS CUI [4])
C0027726 (UMLS CUI [5])
Eligibility Criteria Study Protocol
Item
other protocol-defined inclusion/exclusion criteria may apply.
boolean
C1516637 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])