African American | Age
Item
1. african american men or women 18 - 80 years of age.
boolean
C0085756 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Antihypertensive therapy | Antihypertensive Agents Quantity
Item
2. appropriate therapy for high blood pressure consisting of no more than 2 antihypertensives.
boolean
C0585941 (UMLS CUI [1])
C0003364 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
Marker Quantity Metabolic Syndrome
Item
3. patients with at least one marker of metabolic syndrome as evidenced by:
boolean
C0008963 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0524620 (UMLS CUI [1,3])
Serum HDL cholesterol measurement | Gender
Item
hdl cholesterol < 35mg/dl (men); < 45 mg/dl (women)
boolean
C0428472 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
Triglycerides measurement
Item
triglycerides > 200mg/dl
boolean
C0202236 (UMLS CUI [1])
Fasting blood glucose measurement
Item
fasting glucose >100mg/dl
boolean
C0428568 (UMLS CUI [1])
Waist Circumference | Gender
Item
waist circumference: men >40 inches (102cm); women > 35 (88cm)
boolean
C0455829 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
Copy EKG Recent
Item
4. recent copy of ekg.
boolean
C1948062 (UMLS CUI [1,1])
C0013798 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,3])
Childbearing Potential Contraceptive methods | Hormonal contraception | Barrier Contraception Double | Postmenopausal state | Female Sterilization
Item
5. women able to become pregnant must use reliable contraception (e.g. hormonal contraception and double-barrier methods) throughout this study and for one week after the end of this study. post-menopausal or surgically sterile women.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C2985296 (UMLS CUI [2])
C0004764 (UMLS CUI [3,1])
C0205173 (UMLS CUI [3,2])
C0232970 (UMLS CUI [4])
C0015787 (UMLS CUI [5])
Uncontrolled hypertension
Item
1. uncontrolled hypertension.
boolean
C1868885 (UMLS CUI [1])
Organ Transplantation
Item
2. organ transplant.
boolean
C0029216 (UMLS CUI [1])
Hypersensitivity Investigational New Drugs
Item
3. hypersensitivity to any study medications
boolean
C0020517 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
Systolic Pressure | Diastolic blood pressure
Item
4. systolic pressure 170 or higher or diastolic pressure 110 or higher.
boolean
C0871470 (UMLS CUI [1])
C0428883 (UMLS CUI [2])
Cardiovascular event | Cerebrovascular accident | Myocardial Infarction | Placement of stent | Hospitalization Heart failure Severe
Item
5. cardiovascular events within last 6 months stroke, heart attack, stent, or hospitalization for severe heart failure.
boolean
C1320716 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0522776 (UMLS CUI [4])
C0019993 (UMLS CUI [5,1])
C0018801 (UMLS CUI [5,2])
C0205082 (UMLS CUI [5,3])
Serum potassium measurement
Item
6. serum potassium greater than 5.0
boolean
C0302353 (UMLS CUI [1])
Heart Block Without Pacemaker | Cardiac Arrhythmia | Heart valve disease
Item
7. heart block without a pacemaker, continuing arrhythmia or valvular heart disease.
boolean
C0018794 (UMLS CUI [1,1])
C0332288 (UMLS CUI [1,2])
C0810633 (UMLS CUI [1,3])
C0003811 (UMLS CUI [2])
C0018824 (UMLS CUI [3])
Renal artery occlusion
Item
8. blocked renal artery.
boolean
C0553718 (UMLS CUI [1])
Renal Insufficiency Severe | Creatinine measurement, serum | Gender | Estimated Glomerular Filtration Rate | Dialysis | Nephritic syndrome | Hypertension, Renovascular
Item
9. patients with severe renal impairment (creatinine 1.7 mg/dl for women and 2.0 mg/dl for men and or estimated gfr <30 ml/min) a history of dialysis, nephritic syndrome, or reno-vascular hypertension.
boolean
C1565489 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0201976 (UMLS CUI [2])
C0079399 (UMLS CUI [3])
C3811844 (UMLS CUI [4])
C0011946 (UMLS CUI [5])
C0268732 (UMLS CUI [6])
C0020545 (UMLS CUI [7])
Condition Changing Drug absorption
Item
10. any condition that may alter medication absorption.
boolean
C0348080 (UMLS CUI [1,1])
C0392747 (UMLS CUI [1,2])
C0678745 (UMLS CUI [1,3])
Condition Study Subject Participation Status High risk | Condition Evaluation At risk
Item
11. any condition that may place patient at higher risk from participating in study or will jeopardize the evaluation of efficacy or safety.
boolean
C0348080 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C4319571 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C1261322 (UMLS CUI [2,2])
C1444641 (UMLS CUI [2,3])
Investigational New Drugs
Item
12. use of any investigational study medications within 30 days of enrollment
boolean
C0013230 (UMLS CUI [1])
Medication Regular Unwilling | Medication Regular Unable | Protocol Compliance Unwilling | Protocol Compliance Unable
Item
13. persons unwilling or unable to take regular medications or comply with study protocol.
boolean
C0013227 (UMLS CUI [1,1])
C0205272 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
C0013227 (UMLS CUI [2,1])
C0205272 (UMLS CUI [2,2])
C1299582 (UMLS CUI [2,3])
C0525058 (UMLS CUI [3,1])
C0558080 (UMLS CUI [3,2])
C0525058 (UMLS CUI [4,1])
C1299582 (UMLS CUI [4,2])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods Absent | Female Sterilization | Bilateral tubal ligation | Hormonal contraception | Contraceptive implant Hormonal | Contraceptives, Oral, Hormonal | Barrier Contraception Double
Item
14. pregnant or nursing (lactating) women, or women of childbearing potential (defined as all women physiologically capable of becoming pregnant) who do not use reliable methods of contraception: surgical sterilization, bilateral tubal ligation, hormonal contraception, implantable and oral) and double barrier methods if accepted by local regulatory authority and ethics committee. reliable contraception should be maintained throughout the study and for 7 days after study drug discontinuation.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
C0015787 (UMLS CUI [4])
C0589114 (UMLS CUI [5])
C2985296 (UMLS CUI [6])
C1657106 (UMLS CUI [7,1])
C0458083 (UMLS CUI [7,2])
C0009907 (UMLS CUI [8])
C0004764 (UMLS CUI [9,1])
C0205173 (UMLS CUI [9,2])