Decreased glucose tolerance Oral Glucose Tolerance Test | Impaired fasting glycaemia | Hemoglobin A1c measurement
Item
impaired glucose tolerance assessed by oral glucose tolerance test and/or impaired fasting glucose ( ≥ 5.6 mmol/l) and/or hba1c levels of 5.7-6.4%
boolean
C0151671 (UMLS CUI [1,1])
C0029161 (UMLS CUI [1,2])
C1272092 (UMLS CUI [2])
C0474680 (UMLS CUI [3])
Body mass index
Item
bmi >25 kg/m2
boolean
C1305855 (UMLS CUI [1])
Age
Item
age 40-70 years
boolean
C0001779 (UMLS CUI [1])
Diabetes Mellitus
Item
known diabetes mellitus
boolean
C0011849 (UMLS CUI [1])
Plasma fasting glucose measurement | Hemoglobin A1c measurement
Item
fasting plasma glucose ≥ 7.0 mmol/l or hba1c ≥ 6.5%
boolean
C0583513 (UMLS CUI [1])
C0474680 (UMLS CUI [2])
Immunodeficiency | Immunosuppressive Agents | Tumor necrosis factor alpha blockers | Adrenal Cortex Hormones
Item
immunodeficiency or immunosuppressive treatment (including tnfα blocking agents and corticosteroids)
boolean
C0021051 (UMLS CUI [1])
C0021081 (UMLS CUI [2])
C2170827 (UMLS CUI [3])
C0001617 (UMLS CUI [4])
Anti-Inflammatory Agents | Adrenal Cortex Hormones | Anti-Inflammatory Agents, Non-Steroidal | Aspirin Dose allowed
Item
use of anti-inflammatory drugs ( including corticosteroids and non steroidal anti-inflammatory drugs, 100 mg or less of aspirin is allowed)
boolean
C0003209 (UMLS CUI [1])
C0001617 (UMLS CUI [2])
C0003211 (UMLS CUI [3])
C0004057 (UMLS CUI [4,1])
C0178602 (UMLS CUI [4,2])
C0683607 (UMLS CUI [4,3])
Signs Communicable Disease | Fever | C-reactive protein measurement | Antibiotic therapy | Tuberculosis
Item
signs of current infection (fever, c-reactive protein >30 mmol/l, treatment with antibiotics, previous or current diagnosis of tuberculosis)
boolean
C0311392 (UMLS CUI [1,1])
C0009450 (UMLS CUI [1,2])
C0015967 (UMLS CUI [2])
C0201657 (UMLS CUI [3])
C0338237 (UMLS CUI [4])
C0041296 (UMLS CUI [5])
Recurrent infections
Item
a history of recurrent infections
boolean
C0239998 (UMLS CUI [1])
Pregnancy | Breast Feeding | Contraceptive methods Required
Item
pregnancy or breastfeeding (contraception of at least 3 months before inclusion is required)
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0700589 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
Liver disease | Aspartate aminotransferase increased | Alanine aminotransferase increased
Item
liver disease defined as aspartate aminotransferase or alanine aminotransferase level of more than three times the upper limit of normal range
boolean
C0023895 (UMLS CUI [1])
C0151904 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
Kidney Disease MDRD
Item
renal disease defined as mdrd < 60 ml/min/1.73m2
boolean
C0022658 (UMLS CUI [1,1])
C3839656 (UMLS CUI [1,2])
Neutropenia
Item
neutropenia < 2x 109/l
boolean
C0027947 (UMLS CUI [1])
Study Protocol Comprehension Unable
Item
inability to understand the nature and extent of the trial and the procedures required.
boolean
C2348563 (UMLS CUI [1,1])
C0162340 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
Medical condition Interferes with Study Protocol
Item
any medical condition that might interfere with the current study protocol
boolean
C3843040 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C2348563 (UMLS CUI [1,3])
Study Subject Participation Status | Investigational New Drugs
Item
participation in a drug trial within 60 days prior to the first dose
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])