African American | Parent African American | Grandparent Quantity African American
Item
subjects self-identify racial background, identify themselves, parents and four grandparents as african american
boolean
C0085756 (UMLS CUI [1])
C0030551 (UMLS CUI [2,1])
C0085756 (UMLS CUI [2,2])
C0337471 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0085756 (UMLS CUI [3,3])
Healthy Volunteers | Indication Diabetes Mellitus Oral Glucose Tolerance Test | Diabetes Mellitus, Non-Insulin-Dependent
Item
subject status is healthy volunteer from t in the event that diabetes is indicated in a normal subject based on ogtt results, we will notify the patients' primary care physician. he sophie cohort or diagnosis of t2dm based on american diabetes association (ada) criteria
boolean
C1708335 (UMLS CUI [1])
C3146298 (UMLS CUI [2,1])
C0011849 (UMLS CUI [2,2])
C0029161 (UMLS CUI [2,3])
C0011860 (UMLS CUI [3])
Age
Item
subjects over 18 years old and below 60 years
boolean
C0001779 (UMLS CUI [1])
Healthy Medical History | Healthy Physical Examination | Healthy Laboratory Procedures
Item
subjects who are healthy on the basis of medical history, physical examinations and laboratory tests if healthy volunteer from sophie
boolean
C3898900 (UMLS CUI [1,1])
C0262926 (UMLS CUI [1,2])
C3898900 (UMLS CUI [2,1])
C0031809 (UMLS CUI [2,2])
C3898900 (UMLS CUI [3,1])
C0022885 (UMLS CUI [3,2])
Informed Consent
Item
subjects who agree with the written informed consent to participate in the study
boolean
C0021430 (UMLS CUI [1])
Confirmation of African American Ethnicity Lacking
Item
unable to confirm african-american ethnicity
boolean
C0521091 (UMLS CUI [1,1])
C4540921 (UMLS CUI [1,2])
C0332268 (UMLS CUI [1,3])
Age
Item
under 18 years old
boolean
C0001779 (UMLS CUI [1])
Pregnancy | Breast Feeding | Gender Urine pregnancy test
Item
pregnant or lactating women (female subjects will have a urine pregnancy test at the screening visit).
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0079399 (UMLS CUI [3,1])
C0430056 (UMLS CUI [3,2])
Metformin allergy
Item
prior history of any allergic reaction to metformin
boolean
C0571648 (UMLS CUI [1])
At risk Congestive heart failure | Requirement Pharmacotherapy
Item
has a risk of congestive heart failure requiring pharmacologic treatment (medical history)
boolean
C1444641 (UMLS CUI [1,1])
C0018802 (UMLS CUI [1,2])
C1514873 (UMLS CUI [2,1])
C0013216 (UMLS CUI [2,2])
Renal dysfunction Previous | Liver Dysfunction Previous | Renal function Hematologic Test | Liver function Hematologic Test
Item
has a prior history of renal* or hepatic dysfunction (renal and hepatic function will be evaluated based on screening blood tests conducted prior to study enrollment)
boolean
C3279454 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C0086565 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
C0232804 (UMLS CUI [3,1])
C0018941 (UMLS CUI [3,2])
C0232741 (UMLS CUI [4,1])
C0018941 (UMLS CUI [4,2])
At risk Urinary Retention | At risk Gastric retention | At risk Angle Closure Glaucoma
Item
risk of urinary or gastric retention or narrow-angle glaucoma (by medical history examination)
boolean
C1444641 (UMLS CUI [1,1])
C0080274 (UMLS CUI [1,2])
C1444641 (UMLS CUI [2,1])
C0585136 (UMLS CUI [2,2])
C1444641 (UMLS CUI [3,1])
C0017605 (UMLS CUI [3,2])
Renal Insufficiency | Creatinine clearance measurement Abnormal | Estimated Glomerular Filtration Rate | Creatinine measurement, serum | Gender | Shock | Myocardial Infarction | Septicemia | Cardiac Arrhythmia | Tachyarrhythmia | Heart beat BPM
Item
impaired renal function (e.g as suggested by abnormal creatinine clearance, egfr <60 or serum creatinine >1.4 mg/dl in females and >1.5 mg/dl in males) which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction (heart attack), and septicemia, abnormal heart rhythms (tachyarrhythmias; heart beat > 100 beats per minute).
boolean
C1565489 (UMLS CUI [1])
C0373595 (UMLS CUI [2,1])
C0205161 (UMLS CUI [2,2])
C3811844 (UMLS CUI [3])
C0201976 (UMLS CUI [4])
C0079399 (UMLS CUI [5])
C0036974 (UMLS CUI [6])
C0027051 (UMLS CUI [7])
C0036690 (UMLS CUI [8])
C0003811 (UMLS CUI [9])
C0080203 (UMLS CUI [10])
C0425583 (UMLS CUI [11,1])
C0439385 (UMLS CUI [11,2])
Liver Dysfunction
Item
impaired hepatic function (> 1.5 times the upper limit of normal)
boolean
C0086565 (UMLS CUI [1])
Anemia | Hemoglobin measurement
Item
evidence of anemia (hemoglobin <10 g)
boolean
C0002871 (UMLS CUI [1])
C0518015 (UMLS CUI [2])
Pharmaceutical Preparations Interfere with Research results | SLC22A3 Substrate | SLC22A3 Inhibitor | SLC47A1 Substrate | SLC47A1 Inhibitor | Cimetidine
Item
taking a medication that could confound study results, such as known substrates or inhibitors of oct3 and mate1, such as cimetidine.
boolean
C0013227 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0683954 (UMLS CUI [1,3])
C1420138 (UMLS CUI [2,1])
C3891814 (UMLS CUI [2,2])
C1420138 (UMLS CUI [3,1])
C1999216 (UMLS CUI [3,2])
C1853262 (UMLS CUI [4,1])
C3891814 (UMLS CUI [4,2])
C1853262 (UMLS CUI [5,1])
C1999216 (UMLS CUI [5,2])
C0008783 (UMLS CUI [6])
Informed Consent Lacking
Item
they do not provide consent to participate in the study.
boolean
C0021430 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])