Gastrointestinal cancer metastatic | Malignant neoplasm of kidney | Malignant neoplasm of lung | Disease Progression | Systemic therapy Previous Quantity
Item
patients must have histologically-proven, metastatic gastrointestinal, kidney, or lung cancer who have had disease progression on at least two prior systemic therapies.
boolean
C1096061 (UMLS CUI [1])
C0740457 (UMLS CUI [2])
C0242379 (UMLS CUI [3])
C0242656 (UMLS CUI [4])
C1515119 (UMLS CUI [5,1])
C0205156 (UMLS CUI [5,2])
C1265611 (UMLS CUI [5,3])
ECOG performance status | Life Expectancy
Item
ecog performance status of 0, 1, or 2 and estimated survival of at least 3 months.
boolean
C1520224 (UMLS CUI [1])
C0023671 (UMLS CUI [2])
Effects of Prior Therapy | Patient recovered | White Blood Cell Count Nadir Chemotherapy | Nitrosoureas | Mitomycin
Item
patients must be felt to have recovered from effects of prior therapy, such as past expected wbc nadir for chemotherapy (> 2 weeks for most agents, > 6 weeks for nitrosoureas or mitomycin-c)
boolean
C1704420 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C1115804 (UMLS CUI [2])
C0023508 (UMLS CUI [3,1])
C1708760 (UMLS CUI [3,2])
C0392920 (UMLS CUI [3,3])
C0028210 (UMLS CUI [4])
C0002475 (UMLS CUI [5])
Informed Consent
Item
patient consent must be obtained prior to entrance onto study.
boolean
C0021430 (UMLS CUI [1])
White Blood Cell Count procedure | Platelet Count measurement | Hemoglobin measurement | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Creatinine measurement, serum
Item
white blood count > 3500/mm3; platelet count of at least 100,000/mm3; hemoglobin > 9.0 gm/dl; bilirubin, ast, alt less than 3 times the upper limit of normal; serum creatinine < 1.8.
boolean
C0023508 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0518015 (UMLS CUI [3])
C1278039 (UMLS CUI [4])
C0201899 (UMLS CUI [5])
C0201836 (UMLS CUI [6])
C0201976 (UMLS CUI [7])
Adrenal Cortex Hormones Absent | Immunosuppressive Agents Absent
Item
corticosteroids and immunosuppressive agents are not permitted during the course of the study. patients must have received no corticosteroids or immunosuppressive medications at least 2 weeks prior to entrance on-study.
boolean
C0001617 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0021081 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Fever | Communicable Disease Occult Excluded
Item
patients with elevated temperatures > 100.5 degrees f, must have sources of occult infection excluded.
boolean
C0015967 (UMLS CUI [1])
C0009450 (UMLS CUI [2,1])
C0205262 (UMLS CUI [2,2])
C0332196 (UMLS CUI [2,3])
Childbearing Potential Pregnancy test negative | Childbearing Potential Contraceptive methods
Item
women of childbearing potential must have a negative pregnancy test and must take adequate precautions to prevent pregnancy during treatment.
boolean
C3831118 (UMLS CUI [1,1])
C0427780 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
Cardiovascular Diseases | Myocardial Infarction | Congestive heart failure Uncompensated | Cardiac Arrhythmia Primary | Independent of Electrolyte disorder | Independent of Drug toxicity | Premature ventricular contractions occasional | Angina Pectoris | Cerebrovascular accident
Item
evidence of significant cardiovascular disease including history of recent (< 6 months) myocardial infarction, uncompensated congestive heart failure, primary cardiac arrhythmias (not due to electrolyte disorder or drug toxicity, for example) beyond occasional pvc's, angina, or cerebrovascular accident.
boolean
C0007222 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0018802 (UMLS CUI [3,1])
C0205433 (UMLS CUI [3,2])
C0003811 (UMLS CUI [4,1])
C0205225 (UMLS CUI [4,2])
C0332291 (UMLS CUI [5,1])
C0342579 (UMLS CUI [5,2])
C0332291 (UMLS CUI [6,1])
C0013221 (UMLS CUI [6,2])
C0151636 (UMLS CUI [7,1])
C0521114 (UMLS CUI [7,2])
C0002962 (UMLS CUI [8])
C0038454 (UMLS CUI [9])
Mental disorder Exacerbated Due to Interferon therapy | Mental disorder Excludes Completion Interferon therapy
Item
prior history of psychiatric disorder that could be exacerbated by interferon therapy or which could preclude completion of this therapy.
boolean
C0004936 (UMLS CUI [1,1])
C1444749 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0279030 (UMLS CUI [1,4])
C0004936 (UMLS CUI [2,1])
C0332196 (UMLS CUI [2,2])
C0205197 (UMLS CUI [2,3])
C0279030 (UMLS CUI [2,4])
Pregnancy | Breast Feeding
Item
pregnancy or lactation.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Hypersensitivity Interferon-alpha | Hypersensitivity fluoropyrimidine
Item
history of hypersensitivity to interferon alfa or fluoropyrimidines.
boolean
C0020517 (UMLS CUI [1,1])
C0002199 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0596581 (UMLS CUI [2,2])
Lung disease Severe Resulting in Debilitation | Chronic Obstructive Airway Disease | Requirement Oxygen Therapy Continuous
Item
history of severe debilitating pulmonary disease, such as chronic obstructive pulmonary disease requiring continuous oxygen therapy.
boolean
C0024115 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0332294 (UMLS CUI [1,3])
C0742985 (UMLS CUI [1,4])
C0024117 (UMLS CUI [2])
C1514873 (UMLS CUI [3,1])
C0184633 (UMLS CUI [3,2])
C0549178 (UMLS CUI [3,3])
Autoimmune Disease Requirement Therapeutic immunosuppression
Item
history of autoimmune disease requiring immunosuppression.
boolean
C0004364 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0021079 (UMLS CUI [1,3])
inflammatory joint disease | Inflammatory disorder Systemic | Lupus Erythematosus, Systemic | Exacerbation Due to Interferon therapy
Item
documented inflammatory joint or systemic inflammatory disease (such as lupus) which could be exacerbated by interferon therapy.
boolean
C0683381 (UMLS CUI [1])
C1290884 (UMLS CUI [2,1])
C0205373 (UMLS CUI [2,2])
C0024141 (UMLS CUI [3])
C4086268 (UMLS CUI [4,1])
C0678226 (UMLS CUI [4,2])
C0279030 (UMLS CUI [4,3])