Age
Item
aged at least 18 years of age.
boolean
C0001779 (UMLS CUI [1])
Diffuse large B-cell lymphoma recurrent | Diffuse large B-cell lymphoma refractory | R-CHOP Regimen | Equivalent | High-Dose Chemotherapy with Autologous Stem Cell Transplant | Patients Ineligible High-Dose Chemotherapy with Autologous Stem Cell Transplant
Item
patients with relapsed or refractory diffuse large b-cell lymphoma who have previously received r-chop (or equivalent) chemo-immunotherapy and high dose chemotherapy with stem cell rescue, or who are ineligible for high dose therapy with stem cell rescue.
boolean
C0855111 (UMLS CUI [1])
C0855112 (UMLS CUI [2])
C0393023 (UMLS CUI [3])
C0205163 (UMLS CUI [4])
C1512429 (UMLS CUI [5])
C0030705 (UMLS CUI [6,1])
C1512714 (UMLS CUI [6,2])
C1512429 (UMLS CUI [6,3])
Measurable Disease
Item
measurable disease as defined by cheson et al 2007 criteria.
boolean
C1513041 (UMLS CUI [1])
Pre treatment Excision biopsy Site Suitable | Pre treatment Core needle biopsy Site Suitable
Item
one fresh pre-treatment excisional or core needle biopsy from suitable and accessible site.
boolean
C2709094 (UMLS CUI [1,1])
C0184921 (UMLS CUI [1,2])
C1515974 (UMLS CUI [1,3])
C3900053 (UMLS CUI [1,4])
C2709094 (UMLS CUI [2,1])
C1318309 (UMLS CUI [2,2])
C1515974 (UMLS CUI [2,3])
C3900053 (UMLS CUI [2,4])
WHO performance status scale
Item
world health organization (who) performance status 0 to 1.
boolean
C1298650 (UMLS CUI [1])
Nitrosourea | Mitomycin | Investigational New Drugs | Chemotherapy | Immunotherapy | Antineoplastic Agents | fostamatinib
Item
treatment with nitrosurea, mitomycin c, investigational agents or study drugs w/in28 days of first dose of study treatment, any other chemotherapy, immunotherapy or anticancer agents w/in 3 weeks of first dose of study treatment, previous fostamatinib.
boolean
C0028210 (UMLS CUI [1])
C0002475 (UMLS CUI [2])
C0013230 (UMLS CUI [3])
C0392920 (UMLS CUI [4])
C0021083 (UMLS CUI [5])
C0003392 (UMLS CUI [6])
C2713632 (UMLS CUI [7])
Exception Alopecia | Prior Therapy Resulting in Toxicity CTCAE Grades | Operative Surgical Procedures Resulting in Toxicity CTCAE Grades | Resolution Lacking
Item
with the exception of alopecia, any unresolved toxicities from prior therapy or surgery greater than common terminology criteria for adverse events (ctcae) grade 1.
boolean
C1705847 (UMLS CUI [1,1])
C0002170 (UMLS CUI [1,2])
C1514463 (UMLS CUI [2,1])
C0332294 (UMLS CUI [2,2])
C0600688 (UMLS CUI [2,3])
C1516728 (UMLS CUI [2,4])
C0543467 (UMLS CUI [3,1])
C0332294 (UMLS CUI [3,2])
C0600688 (UMLS CUI [3,3])
C1516728 (UMLS CUI [3,4])
C1514893 (UMLS CUI [4,1])
C0332268 (UMLS CUI [4,2])
Uncontrolled hypertension | Systolic Pressure | Diastolic blood pressure | Antihypertensive therapy | Antihypertensive therapy Absent
Item
uncontrolled hypertension (defined as >140mmhg systolic and/or > 90 mmhg diastolic at baseline with or without antihypertensive therapy.
boolean
C1868885 (UMLS CUI [1])
C0871470 (UMLS CUI [2])
C0428883 (UMLS CUI [3])
C0585941 (UMLS CUI [4])
C0585941 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
Tuberculosis
Item
evidence of tuberculosis (tb).
boolean
C0041296 (UMLS CUI [1])
Few mature neutrophils in the bone marrow
Item
inadequate boen marrow reserve.
boolean
C2748959 (UMLS CUI [1])