Non-Small Cell Lung Carcinoma TNM clinical staging
Item
diagnosis of metastatic stage iv nsclc
boolean
C0007131 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Measurable lesion Quantity | Exception Central nervous system lesion
Item
at least 1 measurable extra-central nervous system (cns) lesion
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0742468 (UMLS CUI [2,2])
Disease Progression Radiography | erlotinib
Item
documented radiographic progression while on continuous treatment with erlotinib monotherapy
boolean
C0242656 (UMLS CUI [1,1])
C0034571 (UMLS CUI [1,2])
C1135135 (UMLS CUI [2])
Benefit Clinical Due to Erlotinib | Partial response | In complete remission | Stable Disease
Item
objective clinical benefit from erlotinib treatment as defined by either documented partial or complete response or stable disease ≥6 months or, if most recent erlotinib treatment has been initiated based on documented epidermal growth factor receptor mutation (egfrmt) status, at least 12 weeks stable disease
boolean
C0814225 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C1135135 (UMLS CUI [1,4])
C1521726 (UMLS CUI [2])
C0677874 (UMLS CUI [3])
C0677946 (UMLS CUI [4])
MET Positive
Item
determined to be met diagnostic positive (+)
boolean
C1417123 (UMLS CUI [1,1])
C1514241 (UMLS CUI [1,2])
Availability of Tumor tissue sample | Disease Progression | Status post Erlotinib
Item
availability of a tumor sample post-erlotinib progression
boolean
C0470187 (UMLS CUI [1,1])
C0475358 (UMLS CUI [1,2])
C0242656 (UMLS CUI [2])
C0231290 (UMLS CUI [3,1])
C1135135 (UMLS CUI [3,2])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status ≤2
boolean
C1520224 (UMLS CUI [1])
Organ function
Item
have adequate organ function
boolean
C0678852 (UMLS CUI [1])
Study Subject Participation Status | Investigational New Drugs | Investigational Medical Device
Item
are currently enrolled in, or discontinued within the last 30 days from, a clinical trial involving an investigational product or non-approved use of a drug or device
boolean
C2348568 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
C2346570 (UMLS CUI [3])
LY2875358 | Targeted Therapy MET
Item
have previously been treated with ly2875358 or any other met-targeting experimental therapeutic
boolean
C2987383 (UMLS CUI [1])
C2985566 (UMLS CUI [2,1])
C1417123 (UMLS CUI [2,2])
Comorbidity Systemic Serious | Heart Disease
Item
have a serious concomitant systemic disorder or significant cardiac disease
boolean
C0009488 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
C0018799 (UMLS CUI [2])
Pneumonia, Interstitial | Interstitial lung fibrosis | Pleural effusion | Pericardial effusion | Ascites | Requirement Drainage Frequency
Item
have interstitial pneumonia or interstitial fibrosis of the lung or have pleural effusion, pericardial fluids or ascites, requiring drainage every other week or more frequently
boolean
C0206061 (UMLS CUI [1])
C3887486 (UMLS CUI [2])
C0032227 (UMLS CUI [3])
C0031039 (UMLS CUI [4])
C0003962 (UMLS CUI [5])
C1514873 (UMLS CUI [6,1])
C0013103 (UMLS CUI [6,2])
C0439603 (UMLS CUI [6,3])
Cancer Other | Exception Basal cell carcinoma | Exception Squamous cell carcinoma of skin | Exception Carcinoma in situ of uterine cervix | Exception Curative treatment Solid Neoplasm | Exception Recurrent disease Free Duration
Item
have a history of another malignancy except for basal or squamous cell skin cancer and/or in situ carcinoma of the cervix, or other solid tumors treated curatively and without evidence of recurrence for at least 3 years prior to the study
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0851140 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C1273390 (UMLS CUI [5,2])
C0280100 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C0277556 (UMLS CUI [6,2])
C0332296 (UMLS CUI [6,3])
C0449238 (UMLS CUI [6,4])
Major surgery
Item
have major surgery less than 2 weeks prior initiation of study treatment therapy
boolean
C0679637 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
CNS metastases Symptomatic
Item
have symptomatic cns metastasis
boolean
C0686377 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])