Secondary malignant neoplasm of female breast HER2 Positive Immunohistochemistry | Secondary malignant neoplasm of female breast HER2 Positive FISH Positive
Item
confirmed diagnosis of metastatic breast cancer her2-positive phenotype (confirmed by ihc 3 + or fish positive)
boolean
C0346993 (UMLS CUI [1,1])
C2348909 (UMLS CUI [1,2])
C0021044 (UMLS CUI [1,3])
C0346993 (UMLS CUI [2,1])
C2348909 (UMLS CUI [2,2])
C0162789 (UMLS CUI [2,3])
C1514241 (UMLS CUI [2,4])
Age
Item
older than 18 years
boolean
C0001779 (UMLS CUI [1])
Prior Therapy Quantity Secondary malignant neoplasm of female breast | trastuzumab | lapatinib | Combined Modality Therapy | Chemotherapy | Hormone Therapy
Item
progressed to at least one prior treatment line for mbc with trastuzumab and / or lapatinib, either as monotherapy or in combination with chemotherapy or hormonal therapy schemes
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0346993 (UMLS CUI [1,3])
C0728747 (UMLS CUI [2])
C1506770 (UMLS CUI [3])
C0009429 (UMLS CUI [4])
C0392920 (UMLS CUI [5])
C0279025 (UMLS CUI [6])
Medical History | Targeted Therapy HER2 Quantity
Item
having the patient's complete medical history that contains all lines antiher2 therapy treatment
boolean
C0262926 (UMLS CUI [1])
C2985566 (UMLS CUI [2,1])
C0069515 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
Initiation Lapatinib/Trastuzumab Regimen
Item
being a patient who initiated the combination of trastuzumab and lapatinib between january 2005 and december 2011
boolean
C1704686 (UMLS CUI [1,1])
C1541246 (UMLS CUI [1,2])
Informed Consent
Item
inform the patient and get the signature of the informed consent
boolean
C0021430 (UMLS CUI [1])
Absence Immunohistochemistry Neoplasm HER2 | Absence FISH Neoplasm HER2
Item
not having phenotypic classification of the tumor by ihc or fish test for her2
boolean
C0332197 (UMLS CUI [1,1])
C0021044 (UMLS CUI [1,2])
C0027651 (UMLS CUI [1,3])
C0069515 (UMLS CUI [1,4])
C0332197 (UMLS CUI [2,1])
C0162789 (UMLS CUI [2,2])
C0027651 (UMLS CUI [2,3])
C0069515 (UMLS CUI [2,4])
Patient HER2 Negative FISH Negative | Patient HER2 Negative Immunohistochemistry
Item
being a patient with her2-negative phenotype(fish negative or ihc in range [0-2 +] without fish)
boolean
C0030705 (UMLS CUI [1,1])
C2348908 (UMLS CUI [1,2])
C0162789 (UMLS CUI [1,3])
C1513916 (UMLS CUI [1,4])
C0030705 (UMLS CUI [2,1])
C2348908 (UMLS CUI [2,2])
C0021044 (UMLS CUI [2,3])
Lapatinib/Trastuzumab Regimen | Chemotherapy | Combined Modality Therapy
Item
being a patient who received the trastuzumab and/or lapatinib treatment (tl) in combination with chemotherapy
boolean
C1541246 (UMLS CUI [1])
C0392920 (UMLS CUI [2])
C0009429 (UMLS CUI [3])
Lapatinib/Trastuzumab Regimen Neoplasm Metastasis | Start time
Item
being a patient who, since january 2012, began tl therapy for metastatic disease.
boolean
C1541246 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C1301880 (UMLS CUI [2])