Age
Item
male or female patients, age >/=18 years
boolean
C0001779 (UMLS CUI [1])
HER2-positive carcinoma of breast Recurrent Locally | HER2-positive carcinoma of breast metastatic
Item
locally recurrent or metastatic her2-positive breast cancer
boolean
C1960398 (UMLS CUI [1,1])
C2945760 (UMLS CUI [1,2])
C1517927 (UMLS CUI [1,3])
C1960398 (UMLS CUI [2,1])
C1522484 (UMLS CUI [2,2])
Disease Progression During Adjuvant therapy | Disease Progression Post Adjuvant therapy | trastuzumab
Item
disease progression during or up to 12 months after prior adjuvant therapy with trastuzumab
boolean
C0242656 (UMLS CUI [1,1])
C0347984 (UMLS CUI [1,2])
C0677850 (UMLS CUI [1,3])
C0242656 (UMLS CUI [2,1])
C0687676 (UMLS CUI [2,2])
C0677850 (UMLS CUI [2,3])
C0728747 (UMLS CUI [3])
Left ventricular ejection fraction
Item
lvef >/=55% at baseline
boolean
C0428772 (UMLS CUI [1])
bevacizumab | capecitabine
Item
prior treatment with bevacizumab or capecitabine
boolean
C0796392 (UMLS CUI [1])
C0671970 (UMLS CUI [2])
Anthracyclines Adjuvant therapy | Anthracyclines Neoadjuvant Therapy | Doxorubicin Cumulative Dose | Epirubicin Cumulative Dose
Item
anthracyclines in prior adjuvant or neoadjuvant treatment exceeding cumulative dose of 360mg/m2 for doxorubicin and 720mg/kg for epirubicin
boolean
C0282564 (UMLS CUI [1,1])
C0677850 (UMLS CUI [1,2])
C0282564 (UMLS CUI [2,1])
C0600558 (UMLS CUI [2,2])
C0013089 (UMLS CUI [3,1])
C2986497 (UMLS CUI [3,2])
C0014582 (UMLS CUI [4,1])
C2986497 (UMLS CUI [4,2])
Adrenal Cortex Hormones chronic U/day | Methylprednisolone Equivalent | Exception Adrenal Cortex Hormones by Inhalation | Aspirin U/day | Clopidogrel U/day
Item
chronic daily treatment with corticosteroids (>10mg/day methylprednisolone equivalent; excluding inhaled corticosteroids), or aspirin (>325mg/day), or clopidogrel (>75mg/day)
boolean
C0001617 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0456683 (UMLS CUI [1,3])
C0025815 (UMLS CUI [2,1])
C0205163 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0001617 (UMLS CUI [3,2])
C0205535 (UMLS CUI [3,3])
C0004057 (UMLS CUI [4,1])
C0456683 (UMLS CUI [4,2])
C0070166 (UMLS CUI [5,1])
C0456683 (UMLS CUI [5,2])
Heart Disease | Cardiotoxicity During Prior Therapy | trastuzumab
Item
clinically significant cardiac disease, or cardiac toxicity during previous trastuzumab therapy
boolean
C0018799 (UMLS CUI [1])
C0876994 (UMLS CUI [2,1])
C0347984 (UMLS CUI [2,2])
C1514463 (UMLS CUI [2,3])
C0728747 (UMLS CUI [3])
Compression of spinal cord | CNS metastases
Item
evidence of spinal cord compression or cns metastasis
boolean
C0037926 (UMLS CUI [1])
C0686377 (UMLS CUI [2])
Cancer Other | Exception Disease Free Duration | Exception Curative treatment Carcinoma in situ of uterine cervix | Exception Curative treatment Skin carcinoma
Item
history of other malignancy, unless disease-free for >/=5 years or treated curatively for carcinoma in situ of the cervix or non-melanomatous skin cancer
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0332296 (UMLS CUI [2,3])
C0449238 (UMLS CUI [2,4])
C1705847 (UMLS CUI [3,1])
C1273390 (UMLS CUI [3,2])
C0851140 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C1273390 (UMLS CUI [4,2])
C0699893 (UMLS CUI [4,3])