age at least 18 Years
Item
Alter mindestens 18 Jahre
boolean
C0001779 (UMLS CUI 2011AA)
397669002 (SNOMED CT 2011_0131)
Female patients, >/= 18 years of age
Item
weiblich
boolean
C0015780 (UMLS CUI 2011AA)
248152002 (SNOMED CT 2011_0131)
F (HL7 V3 2006_05)
Histologically confirmed HER2-negative breast cancer
Item
Histologically confirmed HER2-negative breast cancer
boolean
C0205462 (UMLS CUI 2011AA)
67151002 (SNOMED CT 2011_0131)
C0750484 (UMLS CUI 2011AA)
CL412283 (UMLS CUI 2011AA)
C0011900 (UMLS CUI 2011AA)
439401001 (SNOMED CT 2011_0131)
MTHU008876 (LOINC Version 232)
Disease progression during or following first-line treatment with Avastin and chemotherapy for locally recurrent or metastatic breast cancer
Item
Disease progression during or following first-line treatment with Avastin and chemotherapy for locally recurrent or metastatic breast cancer
boolean
C1947901 (UMLS CUI 2011AA)
C1708063 (UMLS CUI 2011AA)
C0796392 (UMLS CUI 2011AA)
409406007 (SNOMED CT 2011_0131)
C0392920 (UMLS CUI 2011AA)
150415003 (SNOMED CT 2011_0131)
C1282471 (UMLS CUI 2011AA)
314955001 (SNOMED CT 2011_0131)
C0278488 (UMLS CUI 2011AA)
Avastin treatment in first-line setting must have been a minimum of 4 cycles (15 mg/kg) or 6 cycles (10 mg/kg) in combination with chemotherapy
Item
Avastin treatment in first-line setting must have been a minimum of 4 cycles (15 mg/kg) or 6 cycles (10 mg/kg) in combination with chemotherapy
boolean
C1708063 (UMLS CUI 2011AA)
C0796392 (UMLS CUI 2011AA)
409406007 (SNOMED CT 2011_0131)
C1524031 (UMLS CUI 2011AA)
C0439596 (UMLS CUI 2011AA)
44180009 (SNOMED CT 2011_0131)
C1947911 (UMLS CUI 2011AA)
C0392920 (UMLS CUI 2011AA)
150415003 (SNOMED CT 2011_0131)
ECOG performance status 0-2
Item
ECOG performance status 0-2
boolean
C1828078 (UMLS CUI 2011AA)
425389002 (SNOMED CT 2011_0131)
C1827388 (UMLS CUI 2011AA)
422512005 (SNOMED CT 2011_0131)
C1828242 (UMLS CUI 2011AA)
422894000 (SNOMED CT 2011_0131)
At least 28 days since prior radiation therapy or surgery and recovery from treatment
Item
At least 28 days since prior radiation therapy or surgery and recovery from treatment
boolean
C0439231 (UMLS CUI 2011AA)
258706009 (SNOMED CT 2011_0131)
MO (HL7 V3 2006_05)
C1711239 (UMLS CUI 2011AA)
CL414551 (UMLS CUI 2011AA)
C0455610 (UMLS CUI 2011AA)
161615003 (SNOMED CT 2011_0131)
C2004454 (UMLS CUI 2011AA)
C0039798 (UMLS CUI 2011AA)
Anti-angiogenic therapy or anti-vascular endothelial growth factors other than Avastin for first-line treatment
Item
Anti-angiogenic therapy or anti-vascular endothelial growth factors other than Avastin for first-line treatment
boolean
C2363719 (UMLS CUI 2011AA)
10068301 (MedDRA 14.1)
C2267120 (UMLS CUI 2011AA)
CL411789 (UMLS CUI 2011AA)
C0796392 (UMLS CUI 2011AA)
409406007 (SNOMED CT 2011_0131)
C1708063 (UMLS CUI 2011AA)
Active malignancy other than superficial basal cell and superficial squamous cell carcinoma of the skin, or in situ carcinoma of the cervix or breast within the last 5 years
Item
Active malignancy other than superficial basal cell and superficial squamous cell carcinoma of the skin, or in situ carcinoma of the cervix or breast within the last 5 years
boolean
C0205177 (UMLS CUI 2011AA)
55561003 (SNOMED CT 2011_0131)
C0006826 (UMLS CUI 2011AA)
363346000 (SNOMED CT 2011_0131)
10028997 (MedDRA 14.1)
MTHU010328 (LOINC Version 232)
C00-C96 (ICD-10-CM Version 2010)
CL411789 (UMLS CUI 2011AA)
C0205124 (UMLS CUI 2011AA)
26283006 (SNOMED CT 2011_0131)
C0007117 (UMLS CUI 2011AA)
1338007, 254701007 (SNOMED CT 2011_0131)
10004146 (MedDRA 14.1)
C0553723 (UMLS CUI 2011AA)
254651007 (SNOMED CT 2011_0131)
10041834 (MedDRA 14.1)
Inadequate renal function
Item
Inadequate renal function
boolean
C0205412 (UMLS CUI 2011AA)
71978007 (SNOMED CT 2011_0131)
C0232804 (UMLS CUI 2011AA)
11953005 (SNOMED CT 2011_0131)
Clinically relevant cardio-vascular disease
Item
Clinically relevant cardio-vascular disease
boolean
C0205210 (UMLS CUI 2011AA)
58147004 (SNOMED CT 2011_0131)
C2347946 (UMLS CUI 2011AA)
C0007222 (UMLS CUI 2011AA)
105980002 (SNOMED CT 2011_0131)
10007649 (MedDRA 14.1)
429.2 (ICD-9-CM Version 2011)
Known CNS disease except for treated brain metastases
Item
Known CNS disease except for treated brain metastases
boolean
C0007682 (UMLS CUI 2011AA)
23853001 (SNOMED CT 2011_0131)
10007943 (MedDRA 14.1)
G96.9 (ICD-10-CM Version 2010)
C1554961 (UMLS CUI 2011AA)
E (HL7 V3 2006_05)
CL415147 (UMLS CUI 2011AA)
C0220650 (UMLS CUI 2011AA)
10006128 (MedDRA 14.1)
Chronic daily treatment with high-dose aspirin (>325 mg/day) or clopidogrel (>75 mg/day)
Item
Chronic daily treatment with high-dose aspirin (>325 mg/day) or clopidogrel (>75 mg/day)
boolean
C0205191 (UMLS CUI 2011AA)
90734009 (SNOMED CT 2011_0131)
C0332173 (UMLS CUI 2011AA)
69620002 (SNOMED CT 2011_0131)
C0039798 (UMLS CUI 2011AA)
C0444956 (UMLS CUI 2011AA)
261829003 (SNOMED CT 2011_0131)
C0004057 (UMLS CUI 2011AA)
7947003 (SNOMED CT 2011_0131)
C0070166 (UMLS CUI 2011AA)
386952008 (SNOMED CT 2011_0131)
Pregnant or lactating women
Item
Pregnant or lactating women
boolean
C0549206 (UMLS CUI 2011AA)
10036586 (MedDRA 14.1)
C2828358 (UMLS CUI 2011AA)
C0043210 (UMLS CUI 2011AA)
224526002 (SNOMED CT 2011_0131)