Leukemia, B-Cell | B-Cell Lymphoma | Relapse | Refractory Disease | CD19 Positive Flow Cytometry Bone Marrow aspirate | CD22 Positive Flow Cytometry Bone Marrow aspirate | CD19 Positive Immunohistochemistry Bone Marrow aspirate | CD22 Positive Immunohistochemistry Bone Marrow aspirate | CD19 Positive Peripheral blood Biopsy | CD22 Positive Peripheral blood Biopsy | CD19 Positive Biopsy of lymph node | CD22 Positive Biopsy of lymph node | CD19 Positive Tumor Biopsy | CD22 Positive Tumor Biopsy
Item
histologic verification of b-cell lineage leukemia or b cell non-hodgkin lymphoma and evidence of relapse/refractory disease with the presence of cd19 and/or cd22 by flow cytometry or immunohistochemistry of bone marrow aspirate, peripheral blood or node/tumor biopsy
boolean
C2004493 (UMLS CUI [1])
C0079731 (UMLS CUI [2])
C0035020 (UMLS CUI [3])
C1514815 (UMLS CUI [4])
C4289895 (UMLS CUI [5,1])
C0016263 (UMLS CUI [5,2])
C0857285 (UMLS CUI [5,3])
C4329508 (UMLS CUI [6,1])
C0016263 (UMLS CUI [6,2])
C0857285 (UMLS CUI [6,3])
C4289895 (UMLS CUI [7,1])
C0021044 (UMLS CUI [7,2])
C0857285 (UMLS CUI [7,3])
C4329508 (UMLS CUI [8,1])
C0021044 (UMLS CUI [8,2])
C0857285 (UMLS CUI [8,3])
C4289895 (UMLS CUI [9,1])
C0229664 (UMLS CUI [9,2])
C0005558 (UMLS CUI [9,3])
C4329508 (UMLS CUI [10,1])
C0229664 (UMLS CUI [10,2])
C0005558 (UMLS CUI [10,3])
C4289895 (UMLS CUI [11,1])
C0193842 (UMLS CUI [11,2])
C4329508 (UMLS CUI [12,1])
C0193842 (UMLS CUI [12,2])
C4289895 (UMLS CUI [13,1])
C0027651 (UMLS CUI [13,2])
C0005558 (UMLS CUI [13,3])
C4329508 (UMLS CUI [14,1])
C0027651 (UMLS CUI [14,2])
C0005558 (UMLS CUI [14,3])
Refractory Disease Conventional Treatment | Refractory Disease Therapy High priority
Item
disease refractory to conventional therapy and other therapies of higher priority
boolean
C1514815 (UMLS CUI [1,1])
C2945704 (UMLS CUI [1,2])
C1514815 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
C1273516 (UMLS CUI [2,3])
Karnofsky Performance Status | Lansky Play-Performance Status Age Related
Item
karnofsky performance status of ≥ 60% or, if less than 16 years of age, lansky play score of ≥ 60 (appendix ii)
boolean
C0206065 (UMLS CUI [1])
C1522275 (UMLS CUI [2,1])
C0001779 (UMLS CUI [2,2])
C0439849 (UMLS CUI [2,3])
Effects of Prior Therapy | Patient recovered
Item
recovered from effects of prior therapy
boolean
C1704420 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C1115804 (UMLS CUI [2])
Peripheral blast Count
Item
peripheral blast count under 50 x 109/l
boolean
C4087328 (UMLS CUI [1,1])
C0750480 (UMLS CUI [1,2])
Organ function | Cardiac function | Pulmonary function
Item
adequate organ function within 14 days (30 days for cardiac and pulmonary) of treatment start
boolean
C0678852 (UMLS CUI [1])
C0232164 (UMLS CUI [2])
C0231921 (UMLS CUI [3])
Relocation of home Absent | Outpatient Availability of Caregiver
Item
agrees to stay within the twin cities metropolitan area (i.e. within 30 miles of the study center) during the treatment period and has a capable caregiver (outpatient only)
boolean
C2699029 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0029921 (UMLS CUI [2,1])
C0470187 (UMLS CUI [2,2])
C0085537 (UMLS CUI [2,3])
Childbearing Potential Contraceptive methods | Gender Contraceptive methods
Item
women of childbearing potential and men should be advised and agree to practice effective methods of contraception during the course of study
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
Lung disease Parenchymal Leukemic | Lung disease Parenchymal Infectious
Item
presence of leukemic or infectious pulmonary parenchymal disease
boolean
C0024115 (UMLS CUI [1,1])
C4277702 (UMLS CUI [1,2])
C0162679 (UMLS CUI [1,3])
C0024115 (UMLS CUI [2,1])
C4277702 (UMLS CUI [2,2])
C0009450 (UMLS CUI [2,3])
Central nervous system leukaemia
Item
presence of active cns leukemia - csf with <5 wbc/ul will not exclude the patient
boolean
C1332884 (UMLS CUI [1])
Sepsis Uncontrolled
Item
presence of any uncontrolled systemic infection
boolean
C0243026 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Epilepsy Uncontrolled | Epilepsy controlled with medications
Item
documented uncontrolled seizure disorder- a seizure disorder controlled with medication
boolean
C0014544 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0014544 (UMLS CUI [2,1])
C0742801 (UMLS CUI [2,2])
Nervous system disorder
Item
active neurologic disorder - peripheral neuropathy alone does not exclude a patient
boolean
C0027765 (UMLS CUI [1])
Allergy to penicillin | Cephalosporin allergy
Item
documented penicillin or cephalosporin allergies
boolean
C0030824 (UMLS CUI [1])
C0571444 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
pregnant or lactating
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])