Carcinoma of lung TNM clinical staging | EGFR mutation
Item
histologically or cytologically confirmed stage iiib/iv lung cancer with egfr mutation
boolean
C0684249 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C3266992 (UMLS CUI [2])
Disease Progression | Status post Chemotherapy Platinum-Based
Item
progressed after platinum-based chemotherapy
boolean
C0242656 (UMLS CUI [1])
C0231290 (UMLS CUI [2,1])
C0392920 (UMLS CUI [2,2])
C1514162 (UMLS CUI [2,3])
Cancer treatment | gefitinib | erlotinib | icotinib | Tumor Response Duration | Stable Disease Duration
Item
the last anti-tumor therapy before entering this study must be gefitinib, erlotinib or icotinib, and the duration for tumor response must be no less than 4 months, or the duration for stable disease must be no less than 6 months
boolean
C0920425 (UMLS CUI [1])
C1122962 (UMLS CUI [2])
C1135135 (UMLS CUI [3])
C2604307 (UMLS CUI [4])
C0027651 (UMLS CUI [5,1])
C1704632 (UMLS CUI [5,2])
C0449238 (UMLS CUI [5,3])
C0677946 (UMLS CUI [6,1])
C0449238 (UMLS CUI [6,2])
Measurable Disease CT
Item
with a measurable disease with conventional ct) according to recist criteria
boolean
C1513041 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
WHO performance status scale
Item
who performance status(ps)<= 2
boolean
C1298650 (UMLS CUI [1])
Neutrophil count | Platelet Count measurement | Hemoglobin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Secondary malignant neoplasm of liver Absent | Secondary malignant neoplasm of liver | Serum total bilirubin measurement
Item
n>=1.5×109/l, plt>=1.0×109/l,hb>=9g/dl; ast&alt should <2.5uln(without liver metastasis) or <5uln(with liver metastasis).tbil<=1.5uln.
boolean
C0200633 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0518015 (UMLS CUI [3])
C0201899 (UMLS CUI [4])
C0201836 (UMLS CUI [5])
C0494165 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0494165 (UMLS CUI [7])
C1278039 (UMLS CUI [8])
Informed Consent
Item
signed and dated informed consent before the start of specific protocol procedures.
boolean
C0021430 (UMLS CUI [1])
Hypersensitivity Icotinib | Hypersensitivity Arsenic trioxide
Item
allergic to icotinib or arsenic trioxide.
boolean
C0020517 (UMLS CUI [1,1])
C2604307 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0052416 (UMLS CUI [2,2])
Symptoms Metastatic malignant neoplasm to brain
Item
patients with metastatic brain tumors with symptoms.
boolean
C1457887 (UMLS CUI [1,1])
C0220650 (UMLS CUI [1,2])
Systemic disease Severe Uncontrolled | Respiration Disorder Unstable | Heart Disease Unstable | Liver disease Unstable | Kidney Disease Unstable | Respiration Disorder Uncompensated | Heart Disease Uncompensated | Liver disease Uncompensated | Kidney Disease Uncompensated
Item
severe systemic disease out of control such as unstable or uncompensated respiratory,cardiac,liver,renal diseases.
boolean
C0442893 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0035204 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0018799 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C0023895 (UMLS CUI [4,1])
C0443343 (UMLS CUI [4,2])
C0022658 (UMLS CUI [5,1])
C0443343 (UMLS CUI [5,2])
C0035204 (UMLS CUI [6,1])
C0205433 (UMLS CUI [6,2])
C0018799 (UMLS CUI [7,1])
C0205433 (UMLS CUI [7,2])
C0023895 (UMLS CUI [8,1])
C0205433 (UMLS CUI [8,2])
C0022658 (UMLS CUI [9,1])
C0205433 (UMLS CUI [9,2])