Nasopharyngeal Nonkeratinizing Carcinoma
Item
1. patients with newly histologically confirmed non-keratinizing (according to who histologically type).
boolean
C1334926 (UMLS CUI [1])
Age
Item
2. 18 years to 70 years;
boolean
C0001779 (UMLS CUI [1])
Neoplasm TNM clinical staging
Item
3. tumor staged as t3-4n1/n2-3m0 (according to the 7th ajcc edition),
boolean
C0027651 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Karnofsky Performance Status
Item
4. performance status: karnofsky scale (kps) > 70 (appendix i ).
boolean
C0206065 (UMLS CUI [1])
Bone Marrow function | White Blood Cell Count procedure | Neutrophil count (procedure) | Hemoglobin measurement | Platelet Count measurement
Item
5. adequate marrow: leucocyte count > 4×109/l, neutrophil count > 2×109/l, hemoglobin > 90g/l and platelet count > 100×109/l.
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0023508 (UMLS CUI [2])
C0200633 (UMLS CUI [3])
C0518015 (UMLS CUI [4])
C0032181 (UMLS CUI [5])
Liver function | Alanine aminotransferase measurement | Aspartate aminotransferase measurement | Alkaline phosphatase measurement | Serum total bilirubin measurement
Item
6. normal liver function test: alanine aminotransferase (alt), aspartate aminotransferase (ast) < 1.5×upper limit of normal (uln) concomitant with alkaline phosphatase (alp) < 2.5×uln, and bilirubin < uln.
boolean
C0232741 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201850 (UMLS CUI [4])
C1278039 (UMLS CUI [5])
Renal function | Creatinine clearance measurement
Item
7. adequate renal function: creatinine clearance > 60 ml/min.
boolean
C0232804 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Informed Consent
Item
8. patients must be informed of the investigational nature of this study and give written informed consent.
boolean
C0021430 (UMLS CUI [1])
Squamous cell carcinoma, keratinizing | Basaloid squamous cell carcinoma
Item
1. who type keratinizing squamous cell carcinoma or basaloid squamous cell carcinoma.
boolean
C0334247 (UMLS CUI [1])
C1266005 (UMLS CUI [2])
Age
Item
2. age > 70 or < 18.
boolean
C0001779 (UMLS CUI [1])
Therapeutic procedure Palliative intent
Item
3. treatment with palliative intent.
boolean
C0087111 (UMLS CUI [1,1])
C1285530 (UMLS CUI [1,2])
Malignant Neoplasms | Exception Basal cell carcinoma Treated | Exception Squamous cell carcinoma of skin Treated | Exception Carcinoma in situ of uterine cervix
Item
4. prior malignancy except adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer.
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1522326 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0851140 (UMLS CUI [4,2])
Pregnancy | Breast Feeding | Childbearing Potential Pregnancy Tests | Childbearing Potential Contraceptive methods
Item
5. pregnancy or lactation (consider pregnancy test in women of child-bearing age and emphasize effective contraception during the treatment period).
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0032976 (UMLS CUI [3,2])
C3831118 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])
Prior radiation therapy | Exception Therapeutic radiology procedure Skin carcinoma
Item
6. history of previous rt (except for non-melanomatous skin cancers outside intended rt treatment volume).
boolean
C0279134 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C1522449 (UMLS CUI [2,2])
C0699893 (UMLS CUI [2,3])
Prior Chemotherapy Primary tumor | Operative Surgical Procedures Primary tumor | Prior Chemotherapy Lymph nodes | Operative Surgical Procedures Lymph nodes | Exception Diagnostic procedure
Item
7. prior chemotherapy or surgery (except diagnostic) to primary tumor or nodes.
boolean
C1514457 (UMLS CUI [1,1])
C0677930 (UMLS CUI [1,2])
C0543467 (UMLS CUI [2,1])
C0677930 (UMLS CUI [2,2])
C1514457 (UMLS CUI [3,1])
C0024204 (UMLS CUI [3,2])
C0543467 (UMLS CUI [4,1])
C0024204 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0430022 (UMLS CUI [5,2])
Comorbidity Severe At risk Clinical Trial | Comorbidity Severe Affecting Clinical Trial | Heart Disease Unstable Treatment required for | Kidney Disease | Hepatitis, Chronic | Diabetes mellitus poor control | Elevated fasting plasma glucose | Emotional Disturbance
Item
8. any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose > 1.5×uln), and emotional disturbance.
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1444641 (UMLS CUI [1,3])
C0008976 (UMLS CUI [1,4])
C0009488 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0392760 (UMLS CUI [2,3])
C0008976 (UMLS CUI [2,4])
C0018799 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C0332121 (UMLS CUI [3,3])
C0022658 (UMLS CUI [4])
C0019189 (UMLS CUI [5])
C0860161 (UMLS CUI [6])
C4228506 (UMLS CUI [7])
C0013985 (UMLS CUI [8])