Age
Item
males and females between age 18 and 80 years.
boolean
C0001779 (UMLS CUI [1])
Disease length
Item
duration of disease: >5 years
boolean
C0872146 (UMLS CUI [1])
Immunomodulation Multiple Sclerosis | Response failed | Intolerance Immunomodulation | Interferon | Copaxone | Therapeutic immunosuppression | EDSS | Multiple sclerosis relapse Major Quantity | Intolerance to Interferon | Intolerance to Copaxone
Item
failure to respond or intolerance to the currently available multiple sclerosis (ms) immunomodulatory treatments (ie interferons, copaxone, immunosuppression): the lack of response to these treatments will be determined/defined by either an increase (deterioration) of at least one degree in the expanded disability status scale (edss) score during the last year or the appearance of at least two major relapses of ms during the same period of time (under treatment) or intolerance to these agents.
boolean
C1963758 (UMLS CUI [1,1])
C0026769 (UMLS CUI [1,2])
C1704632 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
C0231199 (UMLS CUI [3,1])
C1963758 (UMLS CUI [3,2])
C3652465 (UMLS CUI [4])
C0528175 (UMLS CUI [5])
C0021079 (UMLS CUI [6])
C0451246 (UMLS CUI [7])
C0856120 (UMLS CUI [8,1])
C0205164 (UMLS CUI [8,2])
C1265611 (UMLS CUI [8,3])
C1744706 (UMLS CUI [9,1])
C3652465 (UMLS CUI [9,2])
C1744706 (UMLS CUI [10,1])
C0528175 (UMLS CUI [10,2])
Screening for cancer Appropriate Age | Screening for cancer Appropriate Gender
Item
up to date on all age and gender appropriate cancer screening per american cancer society .
boolean
C0199230 (UMLS CUI [1,1])
C1548787 (UMLS CUI [1,2])
C0001779 (UMLS CUI [1,3])
C0199230 (UMLS CUI [2,1])
C1548787 (UMLS CUI [2,2])
C0079399 (UMLS CUI [2,3])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods Unwilling
Item
females who are pregnant or nursing or females of childbearing potential who are unwilling to maintain contraceptive therapy for the duration of the study
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0558080 (UMLS CUI [3,3])
Life Expectancy Due to Comorbidity
Item
life expectancy < 6 months due to concomitant illnesses.
boolean
C0023671 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
Exposure to Investigational New Drugs | Exposure to Procedure | Study Subject Participation Status Interferes with Research results
Item
exposure to any investigational drug or procedure within 1 month prior to study entry or enrolled in a concurrent study that may confound results of this study.
boolean
C0332157 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
C0332157 (UMLS CUI [2,1])
C0184661 (UMLS CUI [2,2])
C2348568 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0683954 (UMLS CUI [3,3])
Communicable Disease
Item
active infectious disease. for patients who have tested positive, an expert will be consulted as to patient eligibility based on the patient's infectious status
boolean
C0009450 (UMLS CUI [1])
Illness Interferes with Protocol Compliance | Illness compromises Patient safety | Illness Interferes with Interpretation Research results
Item
any illness which, in the investigator's judgment, will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results
boolean
C0221423 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0221423 (UMLS CUI [2,1])
C2945640 (UMLS CUI [2,2])
C1113679 (UMLS CUI [2,3])
C0221423 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0459471 (UMLS CUI [3,3])
C0683954 (UMLS CUI [3,4])
Immunosuppressive therapy for transplant chronic
Item
patients on chronic immunosuppressive transplant therapy
boolean
C0521304 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
Lying systolic blood pressure
Item
systolic blood pressure (supine) ≤90 mmhg;
boolean
C1319895 (UMLS CUI [1])
RESTING HEART RATE
Item
resting heart rate > 100 bpm;
boolean
C1821417 (UMLS CUI [1])
Communicable Disease
Item
active clinical infection.
boolean
C0009450 (UMLS CUI [1])
Cerebrovascular accident
Item
cerebrovascular accident within 6 months prior to study entry
boolean
C0038454 (UMLS CUI [1])
Substance Dependence | Factor Interferes with Completion of clinical trial | Factor Interferes with Interpretation Research results | Factor Study Subject Participation Status Inappropriate
Item
known drug or alcohol dependence or any other factors which will interfere with the study conduct or interpretation of the results or who in the opinion of the investigator are not suitable to participate.
boolean
C0038580 (UMLS CUI [1])
C1521761 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C2732579 (UMLS CUI [2,3])
C1521761 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0459471 (UMLS CUI [3,3])
C0683954 (UMLS CUI [3,4])
C1521761 (UMLS CUI [4,1])
C2348568 (UMLS CUI [4,2])
C1548788 (UMLS CUI [4,3])
Malignant Neoplasms | Exception Skin carcinoma | Exception Carcinoma in situ of uterine cervix
Item
history of cancer (other than non-melanoma skin cancer or in-situ cervical cancer) in the last five years.
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
Informed Consent Unwilling | Informed Consent Unable
Item
unwilling and/or not able to give written informed consent.
boolean
C0021430 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])