Invasive carcinoma of breast Large Operable | Subtype Molecular All | Neoplasm Metastasis Volume Small
Item
newly diagnosed large but operable invasive carcinoma of the breast. all molecular subtypes are eligible and incidentally detected small volume metastatic disease is not an exclusion criterion.
boolean
C0853879 (UMLS CUI [1,1])
C0549177 (UMLS CUI [1,2])
C0205188 (UMLS CUI [1,3])
C0449560 (UMLS CUI [2,1])
C1521991 (UMLS CUI [2,2])
C0444868 (UMLS CUI [2,3])
C0027627 (UMLS CUI [3,1])
C0449468 (UMLS CUI [3,2])
C0700321 (UMLS CUI [3,3])
Indication Chemotherapy Neoadjuvant
Item
clinical indication for nac as determined by the breast therapeutic mdt.
boolean
C3146298 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
C1298676 (UMLS CUI [1,3])
Biopsy Material Sufficient | Biological Markers Measurement
Item
sufficient biopsy material taken at diagnosis to measure the standard molecular markers.
boolean
C0005558 (UMLS CUI [1,1])
C0520510 (UMLS CUI [1,2])
C0205410 (UMLS CUI [1,3])
C0005516 (UMLS CUI [2,1])
C0242485 (UMLS CUI [2,2])
Informed Consent
Item
participant is willing and able to give informed consent for participation in the study.
boolean
C0021430 (UMLS CUI [1])
Gender | Age
Item
female, aged 18 years or above.
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Invasive carcinoma of breast | Prior Therapy Absent
Item
histologically or cytologically confirmed invasive carcinoma of the breast and having received no prior treatment for this.
boolean
C0853879 (UMLS CUI [1])
C1514463 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Childbearing Potential Contraceptive methods | Childbearing Potential Partner Contraceptive methods
Item
female participants of child bearing potential must be willing to ensure that they or their partner use effective contraception during the study.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0682323 (UMLS CUI [2,2])
C0700589 (UMLS CUI [2,3])
Renal function | Estimated Glomerular Filtration Rate
Item
participant has adequate renal function (estimated glomerular filtration rate ≥ 30 ml/min).
boolean
C0232804 (UMLS CUI [1])
C3811844 (UMLS CUI [2])
Protocol Compliance
Item
in the investigator's opinion, is able and willing to comply with all study requirements.
boolean
C0525058 (UMLS CUI [1])
Therapeutic radiology procedure Breast Carcinoma Previous | Chemotherapy Breast Carcinoma Previous | Breast cancer recurrent
Item
previous breast cancer treated with radiotherapy or chemotherapy or recurrent breast cancer.
boolean
C1522449 (UMLS CUI [1,1])
C0678222 (UMLS CUI [1,2])
C0205156 (UMLS CUI [1,3])
C0392920 (UMLS CUI [2,1])
C0678222 (UMLS CUI [2,2])
C0205156 (UMLS CUI [2,3])
C0278493 (UMLS CUI [3])
Pregnancy | Breast Feeding | Pregnancy, Planned
Item
female participant who is pregnant, lactating or planning pregnancy during the course of the study.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032992 (UMLS CUI [3])
Renal Insufficiency | Estimated Glomerular Filtration Rate
Item
significant renal impairment (estimated glomerular filtration rate < 30 ml/min).
boolean
C1565489 (UMLS CUI [1])
C3811844 (UMLS CUI [2])
Medical contraindication MRI
Item
contraindication to mri.
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])