Invasive carcinoma of breast
Item
diagnosis of invasive breast cancer
boolean
C0853879 (UMLS CUI [1])
Paclitaxel | Systemic therapy Curative | Neoadjuvant Therapy Disease | Adjuvant therapy Disease | Neoplasm Metastasis Few
Item
systemic treatment with paclitaxel for curative intent (neoadjuvant, adjuvant, or oligometastatic disease per pi discretion)
boolean
C0144576 (UMLS CUI [1])
C1515119 (UMLS CUI [2,1])
C1276305 (UMLS CUI [2,2])
C0600558 (UMLS CUI [3,1])
C0012634 (UMLS CUI [3,2])
C0677850 (UMLS CUI [4,1])
C0012634 (UMLS CUI [4,2])
C0027627 (UMLS CUI [5,1])
C0205388 (UMLS CUI [5,2])
Infusions U/week
Item
80 mg/m2 1-hour infusions weekly for up to 12 weeks
boolean
C0574032 (UMLS CUI [1,1])
C0560588 (UMLS CUI [1,2])
Gender
Item
female sex
boolean
C0079399 (UMLS CUI [1])
Age
Item
>18 years old
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
ability to understand and the willingness to sign a written informed consent.
boolean
C0021430 (UMLS CUI [1])
Chemotherapy Neurotoxic agents | taxane | Vinca Alkaloids | Platinum | bortezomib | Thalidomide
Item
any prior or concurrent treatment with neurotoxic chemotherapy including any taxane, vinca alkaloid, platinum, bortezomib, or thalidomide. note that concurrent biologic treatment with trastuzumab/pertuzumab for her2+ patients or prior treatment with adriamycin/cyclophosphamide are not reasons for exclusion.
boolean
C0392920 (UMLS CUI [1,1])
C0260049 (UMLS CUI [1,2])
C0215136 (UMLS CUI [2])
C0042672 (UMLS CUI [3])
C0032207 (UMLS CUI [4])
C1176309 (UMLS CUI [5])
C0039736 (UMLS CUI [6])
Distant metastasis
Item
distant metastatic disease
boolean
C1269798 (UMLS CUI [1])
duloxetine | Study Subject Participation Status | Neuroprotective Agents
Item
concurrent treatment with duloxetine or enrollment on clinical study of neuroprotective agent
boolean
C0245561 (UMLS CUI [1])
C2348568 (UMLS CUI [2])
C0242912 (UMLS CUI [3])
Paclitaxel allergy | Hypersensitivity Cremophor EL
Item
history of allergic reaction to paclitaxel or cremophor el
boolean
C0570707 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0056476 (UMLS CUI [2,2])
Sign or Symptom Peripheral Neuropathy Severe
Item
current signs or symptoms of severe peripheral neuropathy
boolean
C3540840 (UMLS CUI [1,1])
C0031117 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
Family history Hereditary peripheral neuropathy | Family history of Charcot-Marie-Tooth disease
Item
known family history of hereditary peripheral neuropathy or charcot-marie-tooth disease
boolean
C0241889 (UMLS CUI [1,1])
C0392553 (UMLS CUI [1,2])
C2316866 (UMLS CUI [2])
Pregnancy
Item
known current pregnancy
boolean
C0032961 (UMLS CUI [1])