knee and hip oa

men and women >45 years of age

any other type of arthritis

chronic pain syndrome

arthroscopic surgery in the past 8 months

intra-articular corticosteroidsin the past 8 months

hyaluronic acid injections in the past 8 months

narcotic pain killers use

renal or hepatic disease

body mass index (bmi) >45 kg/m2

cancer