age: 18-65 years

expanded disability status scale (edss) ≤6 (pyramidal functional system ≥3)

clinically relevant cognitive disorders;

disability caused by other diseases;

medication with corticosteroids within three months prior to enrolment;

medication with botulinum toxin within six months prior to enrolment;

clinically or radiologically documented exacerbation within six months prior to enrolment;

variations in disease-modifying drugs (dmd) within three months prior to enrolment;

severe ataxia and postural instability (assessed with berg balance scale);

depression