postmenopausal hr positive breast cancer patients;

inoperable locally advanced or metastatic breast cancer patients;

candidate for endocrine therapy;

ecog equal to or less than 1;

adequate bone marrow function(hb>=90g/l, wbc >=3.5×10^9/l,anc>=1.5×10^9/l, plt>=80×10^9/l; adequate renal function(ccr<=uln);adequate liver function(alt,ast,akp<=2.5*uln,or <=5*uln if liver metastases)

life expectancy >=12weeks;

no severe history disease of liver,heart,lung or kidney;

written informed consent form;

her-2 overexpression;

patients who has visceral endocrisis；