diagnosis of enthesitis related arthritis (era) as defined by international league of associations for rheumatology (ilar);

disease activity defined as at least 3 active joints and evidence of enthesitis in at least one location;

inadequate response or intolerance to at least one nonsteroidal anti-inflammatory drug and at least one disease modifying anti-rheumatic drug, either sulfasalazine or methotrexate.

any ilar juvenile idiopathic arthritis (jia) subtype other than era;

psoriasis or a history of psoriasis in the patient or first-degree relative;

presence of immunoglobulin m (igm) rheumatoid factor;

presence of systemic jia,

history of inflammatory bowel disease, previous biologic therapy including anti-tnf therapy with a potential impact on pediatric era;

infection(s) requiring treatment with iv anti-infectives within 30 days prior to baseline or oral anti-infectives within 14 days prior to baseline