patients with histologically confirmed adenocarcinoma

primary lesions (colorectal cancer) are resected

must have undergone prior complete resection of the primary tumor; liver metastases

must be resectable or accessible for radiofrequency ablation (five or less lung metastases measuring 5 cm or smaller).

serum bilirubin level of 2.0 mg/dl or less.

performance status of 0 or 1.

expected survival of 1 year or more.

informed consent from the patient.

with extrahepatic metastases

with other neoplastic disease that is measurable or being treated other than colorectal cancer.