a long-term indication for oral anticoagulation treatment (until at least 1 year after the study)

a severe coronary lesion (at least 75% stenosis on angiography or fractional flow reserve lower than 0•80) with indication for pci

age 18-80 years

history of intracranial bleeding;

cardiogenic shock;

contra indication to use of antiplatelet or anticoagulation drugs;

peptic ulcer in the previous 6 months;

thrombo cytopenia (platelet concentration lower than 50~10⁹/l);

major bleeding (according to the thrombolysis in myocardial infarction [timi] criteria) in the past 12 months; and

pregnancy.