Refractory plasma cell neoplasm | Plasma cell myeloma recurrent | Status post First line Chemotherapy | Status post Peripheral Stem Cell Transplantation | Status post Transplantation of autologous hematopoietic stem cell | Status post Allogeneic Stem Cell Transplantation
Item
patients with refractory or relapsed mm after at least first-line chemotherapy (ctx) or pbsct (autologous and allogeneic sct). all lines of relapse are eligible.
boolean
C0278620 (UMLS CUI [1])
C1370446 (UMLS CUI [2])
C0231290 (UMLS CUI [3,1])
C1708063 (UMLS CUI [3,2])
C0392920 (UMLS CUI [3,3])
C0231290 (UMLS CUI [4,1])
C0242602 (UMLS CUI [4,2])
C0231290 (UMLS CUI [5,1])
C1831743 (UMLS CUI [5,2])
C0231290 (UMLS CUI [6,1])
C2242529 (UMLS CUI [6,2])
Karnofsky Performance Status
Item
kps ≥60%
boolean
C0206065 (UMLS CUI [1])
Bone Marrow function
Item
adequate bm function
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
Liver function | Renal function | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Serum total bilirubin measurement | Estimated Glomerular Filtration Rate
Item
adequate hepatic and renal function (ast and alt ≤2.5 times uln, bilirubin ≤1.5 times uln, egfr >20 ml/min)
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C1278039 (UMLS CUI [5])
C3811844 (UMLS CUI [6])
Vorinostat | Histone deacetylase inhibitor
Item
patient has had prior treatment with vorinostat or hdac inhibitors
boolean
C0672708 (UMLS CUI [1])
C1512474 (UMLS CUI [2])
Hepatic impairment Severe | Diffuse infiltrative lung disease | Disorder of pericardium Diffusely infiltrative
Item
patients with severe hepatic impairment or acute diffuse infiltrative pulmonary and pericardial disease
boolean
C0948807 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0340110 (UMLS CUI [2])
C0265122 (UMLS CUI [3,1])
C3842356 (UMLS CUI [3,2])
Neuropathy Pre-existing CTCAE Grades
Item
patient has preexisting nci ctc ≥grade 3 neuropathy
boolean
C0442874 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C1516728 (UMLS CUI [1,3])
Central Nervous System Involvement with Multiple Myeloma | Meningitis Multiple Myeloma Related | Meningitis Multiple Myeloma Induced
Item
patient with known cns mm-involvement and/or mm-related/induced meningitis
boolean
C3714787 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C0026764 (UMLS CUI [1,3])
C0025289 (UMLS CUI [2,1])
C0026764 (UMLS CUI [2,2])
C0439849 (UMLS CUI [2,3])
C0025289 (UMLS CUI [3,1])
C0026764 (UMLS CUI [3,2])
C0205263 (UMLS CUI [3,3])