Age
Item
age>18
boolean
C0001779 (UMLS CUI [1])
Karnofsky Performance Status
Item
karnofsky performance status (kps) ≥ 70
boolean
C0206065 (UMLS CUI [1])
Thymoma Newly Diagnosed WHO tumor classification | Thymoma malignant recurrent WHO tumor classification | Thymic Carcinoma
Item
newly diagnosed or recurrent thymoma - who a, ab, b1, b2, or b340, or thymic carcinoma pathologically confirmed at mskcc, mdacc or city of hope
boolean
C0040100 (UMLS CUI [1,1])
C1518321 (UMLS CUI [1,2])
C1301142 (UMLS CUI [1,3])
C0278848 (UMLS CUI [2,1])
C1301142 (UMLS CUI [2,2])
C0205969 (UMLS CUI [3])
Absence Prior Chemotherapy Thymoma | Absence Prior radiation therapy Thymoma | Absence Operative Surgical Procedures Thymoma | Exception Biopsy
Item
no prior chemotherapy, radiotherapy, or surgical therapy (other than for diagnostic biopsy) for thymoma
boolean
C0332197 (UMLS CUI [1,1])
C1514457 (UMLS CUI [1,2])
C0040100 (UMLS CUI [1,3])
C0332197 (UMLS CUI [2,1])
C0279134 (UMLS CUI [2,2])
C0040100 (UMLS CUI [2,3])
C0332197 (UMLS CUI [3,1])
C0543467 (UMLS CUI [3,2])
C0040100 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0005558 (UMLS CUI [4,2])
Cetuximab Absent
Item
no prior treatment with cetuximab
boolean
C0995188 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
Masaoka Staging System | Tumor Invasion Suspected Mediastinum | Tumor Invasion Suspected Pericardium | Tumor Invasion Suspected Lung | Tumor Invasion Suspected Great vessels | Tumor Invasion Suspected Chest wall | Secondary malignant neoplasm of pleura | Bone Marrow function | White Blood Cell Count procedure | Absolute neutrophil count | Platelet Count measurement
Item
clinical masaoka stage ii (>5cm), iii, or iva(see appendix b), including suspected invasion of mediastinum, pericardium, lung, great vessels or chest wall, and/or pleural metastases normal marrow function: leukocytes ≥ 4,000/μl, absolute neutrophil count ≥ 1,500/μl, platelets ≥ 160,000/μl
boolean
C3827366 (UMLS CUI [1])
C1269955 (UMLS CUI [2,1])
C0750491 (UMLS CUI [2,2])
C0025066 (UMLS CUI [2,3])
C1269955 (UMLS CUI [3,1])
C0750491 (UMLS CUI [3,2])
C0031050 (UMLS CUI [3,3])
C1269955 (UMLS CUI [4,1])
C0750491 (UMLS CUI [4,2])
C0024109 (UMLS CUI [4,3])
C1269955 (UMLS CUI [5,1])
C0750491 (UMLS CUI [5,2])
C0225991 (UMLS CUI [5,3])
C1269955 (UMLS CUI [6,1])
C0750491 (UMLS CUI [6,2])
C0205076 (UMLS CUI [6,3])
C0153678 (UMLS CUI [7])
C0005953 (UMLS CUI [8,1])
C0031843 (UMLS CUI [8,2])
C0023508 (UMLS CUI [9])
C0948762 (UMLS CUI [10])
C0032181 (UMLS CUI [11])
Renal function | Creatinine measurement, serum | Estimation of creatinine clearance by Cockcroft-Gault formula
Item
adequate renal function, with creatinine ≤ 1.3 mg/dl or calculated creatinine clearance ≥60ml/min by cockcroft and gault equation using parameters of age, weight (kg), and baseline serum creatinine (mg/dl)
boolean
C0232804 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C2711451 (UMLS CUI [3])
Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alkaline phosphatase measurement
Item
adequate hepatic function: total bilirubin ≤1.5 mg/dl, ast ≤1.5x unl, alkaline phosphatase ≤1.5 un
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201850 (UMLS CUI [4])
Informed Consent
Item
signed informed consent
boolean
C0021430 (UMLS CUI [1])
Contraceptive methods
Item
effective contraception
boolean
C0700589 (UMLS CUI [1])
Operable
Item
medically operable
boolean
C0205188 (UMLS CUI [1])
Distant metastasis Masaoka Staging System
Item
evidence of distant metastatic disease (masaoka stage ivb)
boolean
C1269798 (UMLS CUI [1,1])
C3827366 (UMLS CUI [1,2])
Thymic Carcinoid
Item
thymic carcinoid
boolean
C1336746 (UMLS CUI [1])
Investigational New Drugs
Item
patients must not be receiving any other investigational agents
boolean
C0013230 (UMLS CUI [1])
Malignant Neoplasms | Exception Skin carcinoma | Exception Carcinoma in situ of uterine cervix
Item
concurrent or prior malignancy in the last 5 years other than non-melanoma skin cancer and in-situ carcinoma of the cervix
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
Antiretroviral therapy Combination HIV Seropositivity | Drug Interactions Investigational New Drugs | Pharmaceutical Preparations Changing CYP3A4
Item
known hiv-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible pharmacokinetic interactions with the study drugs. patients on medications known to alter cyp3a4
boolean
C1963724 (UMLS CUI [1,1])
C0205195 (UMLS CUI [1,2])
C0019699 (UMLS CUI [1,3])
C0687133 (UMLS CUI [2,1])
C0013230 (UMLS CUI [2,2])
C0013227 (UMLS CUI [3,1])
C0392747 (UMLS CUI [3,2])
C3714798 (UMLS CUI [3,3])
Pregnancy | Breast Feeding
Item
pregnant or breastfeeding women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])