Colorectal Carcinoma Inoperable
Item
histologically proven inoperable colorectal cancer
boolean
C0009402 (UMLS CUI [1,1])
C0205187 (UMLS CUI [1,2])
Adult | Age
Item
adult patients >= 18 years of age
boolean
C0001675 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
ECOG performance status
Item
ecog <2
boolean
C1520224 (UMLS CUI [1])
Chemotherapy | Immunotherapy | Exception Adjuvant therapy Non-Metastatic Neoplasm | Exception Neoadjuvant Therapy Non-Metastatic Neoplasm | Disease Progression
Item
preceding chemo- or immunotherapy with the exception of adjuvant or neoadjuvant treatment of non-metastatic disease ending ≥ 6 month prior to study inclusion. progression within 6 month after the end of adjuvant therapy must be excluded.
boolean
C0392920 (UMLS CUI [1])
C0021083 (UMLS CUI [2])
C1705847 (UMLS CUI [3,1])
C0677850 (UMLS CUI [3,2])
C1334991 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0600558 (UMLS CUI [4,2])
C1334991 (UMLS CUI [4,3])
C0242656 (UMLS CUI [5])
Cancer Other | Exception Basal cell carcinoma | Exception Carcinoma in situ of uterine cervix Treated Successful
Item
other malignancies with the exception of basal cell carcinoma or successfully treated carcinoma in situ of the cervix uteri.
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C1272703 (UMLS CUI [3,4])
Comorbidity Severe | Uncontrolled hypertension | Gastrointestinal Hemorrhage | Congestive heart failure New York Heart Association Classification | Coronary heart disease Symptomatic | Myocardial Infarction | Cardiac Arrhythmia Serious Requirement Pharmaceutical Preparations | Peripheral Vascular Diseases CTCAE Grades | Comorbidity Severe Uncontrolled
Item
no history of severe comorbidities, i. e. uncontrolled hypertension, gi-bleeding, congestive heart-failure nyha class ii-iv, symptomatic coronary heart disease, myocardial infarction within 1 year prior to study inclusion, serious cardiac arrhythmias requiring medication, grade ii or greater peripheral vascular disease and other severe uncontrolled co-morbidities
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1868885 (UMLS CUI [2])
C0017181 (UMLS CUI [3])
C0018802 (UMLS CUI [4,1])
C1275491 (UMLS CUI [4,2])
C0010068 (UMLS CUI [5,1])
C0231220 (UMLS CUI [5,2])
C0027051 (UMLS CUI [6])
C0003811 (UMLS CUI [7,1])
C0205404 (UMLS CUI [7,2])
C1514873 (UMLS CUI [7,3])
C0013227 (UMLS CUI [7,4])
C0085096 (UMLS CUI [8,1])
C1516728 (UMLS CUI [8,2])
C0009488 (UMLS CUI [9,1])
C0205082 (UMLS CUI [9,2])
C0205318 (UMLS CUI [9,3])
Cerebrovascular accident | CNS disorder | Malignant Neoplasms | Seizures | Transient Ischemic Attack
Item
no history of stroke or other cns-diseases (tumors, seizure, transient ischemic attack etc.)
boolean
C0038454 (UMLS CUI [1])
C0007682 (UMLS CUI [2])
C0006826 (UMLS CUI [3])
C0036572 (UMLS CUI [4])
C0007787 (UMLS CUI [5])
Peripheral arterial occlusive disease CTCAE Grades
Item
≥ grade ii peripheral artery vascular occlusive disease
boolean
C1306889 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Neuropathy Pre-existing CTCAE Grades
Item
preexisting neuropathy ≥ grade 1
boolean
C0442874 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C1516728 (UMLS CUI [1,3])
Pneumonia, Interstitial | Pulmonary Fibrosis
Item
interstitial pneumonia or lung fibrosis
boolean
C0206061 (UMLS CUI [1])
C0034069 (UMLS CUI [2])
Wound Non-healing Serious | Ulcer | Fracture
Item
serious, nonhealing wound, ulcer, or bone fracture
boolean
C0043250 (UMLS CUI [1,1])
C0205301 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
C0041582 (UMLS CUI [2])
C0016658 (UMLS CUI [3])
Therapeutic radiology procedure Indicator Lesion | Exception Progressive Disease
Item
preceding irradiation an indicator lesion except for documented progressive disease during irradiation and termination of irradiation ≥ 4 weeks from study inclusion
boolean
C1522449 (UMLS CUI [1,1])
C1522602 (UMLS CUI [1,2])
C0221198 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C1335499 (UMLS CUI [2,2])
Thromboembolism | Event Hemorrhagic
Item
thromboembolic or bleeding events within the last 6 month
boolean
C0040038 (UMLS CUI [1])
C0441471 (UMLS CUI [2,1])
C0333275 (UMLS CUI [2,2])
Patient need for Anticoagulation Therapy | heparin | coumarin
Item
need for therapeutic anticoagulation (heparin, cumarin)
boolean
C0686904 (UMLS CUI [1,1])
C0003281 (UMLS CUI [1,2])
C0019134 (UMLS CUI [2])
C0010206 (UMLS CUI [3])
ASS U/day | NSAR
Item
use of ass > 325 mg/die or nsar
boolean
C0004057 (UMLS CUI [1,1])
C0456683 (UMLS CUI [1,2])
C0068238 (UMLS CUI [2])
Proteinuria | Urine protein test
Item
proteinuria > 1+ (stix) as long as urine protein >1g/24h
boolean
C0033687 (UMLS CUI [1])
C0262923 (UMLS CUI [2])