Age
Item
1. age 19-59
boolean
C0001779 (UMLS CUI [1])
Schizophrenia Mini-mental state examination
Item
2. diagnosis of schizophrenia by mini
boolean
C0036341 (UMLS CUI [1,1])
C0451306 (UMLS CUI [1,2])
Cognitive Assessment Score
Item
3. cognition score 1 standard deviation below published norms in controls
boolean
C0870300 (UMLS CUI [1,1])
C0449820 (UMLS CUI [1,2])
Clinical status Stable | Antipsychotic Agent Dose Stable
Item
4. clinically stable for 12 weeks i.e. on the same antipsychotic(s) for 8 weeks and stable dose for at least 4 weeks
boolean
C0449440 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0040615 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
Hallucinations Moderate BPRS | Delusions Moderate BPRS | Disorder of form of thought Moderate BPRS | PANSS Symptoms Negative
Item
5. have no more than moderate severity rating on hallucinations, delusions formal thought disorder (bprs), negative symptoms (panss_n)
boolean
C0018524 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C0029941 (UMLS CUI [1,3])
C0011253 (UMLS CUI [2,1])
C0205081 (UMLS CUI [2,2])
C0029941 (UMLS CUI [2,3])
C0233636 (UMLS CUI [3,1])
C0205081 (UMLS CUI [3,2])
C0029941 (UMLS CUI [3,3])
C4086747 (UMLS CUI [4,1])
C1457887 (UMLS CUI [4,2])
C1513916 (UMLS CUI [4,3])
Extrapyramidal symptoms Minimal | Rating scale Extrapyramidal tract Side effects
Item
6. minimal eps (simpson-angus <6)
boolean
C0234133 (UMLS CUI [1,1])
C0547040 (UMLS CUI [1,2])
C0681889 (UMLS CUI [2,1])
C0015372 (UMLS CUI [2,2])
C0879626 (UMLS CUI [2,3])
Minimal depression | Depression scale Schizophrenia
Item
7. minimal depression (calgary <10)
boolean
C4305327 (UMLS CUI [1])
C0679604 (UMLS CUI [2,1])
C0036341 (UMLS CUI [2,2])
Psychotropic Drugs Dose Stable
Item
8. stable dose of other psychotropics (2 months)
boolean
C0033978 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Pregnancy Absent
Item
9. not pregnant.
boolean
C0032961 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
Peptic Ulcer Disease length
Item
1. history of active peptic ulcer disease within 1 year of screening
boolean
C0030920 (UMLS CUI [1,1])
C0872146 (UMLS CUI [1,2])
Cardiac Arrhythmia
Item
2. clinically significant cardiac arrhythmia
boolean
C0003811 (UMLS CUI [1])
Pulse Rate At rest
Item
3. resting pulse less than 50
boolean
C0232117 (UMLS CUI [1,1])
C0443144 (UMLS CUI [1,2])
Malignant Neoplasms | Exception Skin carcinoma
Item
4. active cancer (skin tumors other than melanoma are not excluded)
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
Cerebrovascular accident
Item
5. history of clinically significant stroke
boolean
C0038454 (UMLS CUI [1])
Epilepsy | Lesion of brain Focal
Item
6. current evidence or history in the past 2 years of epilepsy, focal brain lesion
boolean
C0014544 (UMLS CUI [1])
C0221505 (UMLS CUI [2,1])
C0205234 (UMLS CUI [2,2])
Cholinesterase Inhibitors | Nootropic Agents | Galantamine | rivastigmine | donepezil | Vitamin E | Memantine | Anticholinergic Agents
Item
7. start of cholinesterase inhibitors/ cognitive enhancers (galantamine, rivastigmine, donepezil, vitamin e and memantine) within 2 months of screening, 8. use of medications with significant central nervous system anticholinergic activity within 2 months of screening.
boolean
C0008425 (UMLS CUI [1])
C0242913 (UMLS CUI [2])
C0016967 (UMLS CUI [3])
C0649350 (UMLS CUI [4])
C0527316 (UMLS CUI [5])
C0042874 (UMLS CUI [6])
C0025242 (UMLS CUI [7])
C0242896 (UMLS CUI [8])