Parkinson Disease
Item
1. uk parkinson's disease society (ukpds) brain bank criteria (step 1 and 2) for pd.
boolean
C0030567 (UMLS CUI [1])
Parkinson Disease Modified Hoehn and Yahr Scale score
Item
2. pd stages 2-4 in the off state for modified hoehn and yahr scale.
boolean
C0030567 (UMLS CUI [1,1])
C4274318 (UMLS CUI [1,2])
Levodopa | DOPA Decarboxylase Inhibitors
Item
3. on levodopa/dopa-decarboxylase inhibitor for at least one year.
boolean
C0023570 (UMLS CUI [1])
C0598272 (UMLS CUI [2])
Levodopa Dose Quantity U/day
Item
4. taking at least three doses and >=300mg of levodopa per day for at least four weeks before randomization.
boolean
C0023570 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0456683 (UMLS CUI [1,4])
Dose Wearing off effect End Expected
Item
5. predictable end of dose wearing off.
boolean
C0178602 (UMLS CUI [1,1])
C1504539 (UMLS CUI [1,2])
C2746065 (UMLS CUI [1,3])
C1517001 (UMLS CUI [1,4])
Subject Diary Parkinson Disease Completion | Other Coding
Item
6. able to satisfactorily complete hauser based 24-hour patient parkinson's diary.
boolean
C3890583 (UMLS CUI [1,1])
C0030567 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
C3846158 (UMLS CUI [2])
Off Treatment Time Period Average | Subject Diary Hour Quantity
Item
7. have an average of two hours of off time on 24-hour diaries.
boolean
C1518544 (UMLS CUI [1,1])
C1948053 (UMLS CUI [1,2])
C1510992 (UMLS CUI [1,3])
C3890583 (UMLS CUI [2,1])
C0439227 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
Other Antiparkinson Agents Regimen Stable
Item
8. on a stable regimen of any other anti-parkinson's drugs for at least four weeks before randomization.
boolean
C1579414 (UMLS CUI [1,1])
C0040808 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
Age
Item
9. be at least 20 years of age.
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
10. be willing and able to give written informed consent.
boolean
C0021430 (UMLS CUI [1])
Pharmaceutical Preparations Excluded
Item
1. taking any excluded medications.
boolean
C0013227 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
Neurosurgical Procedures Parkinson Disease | Transcranial magnetic stimulation Parkinson Disease
Item
2. neurosurgical treatment or transcranial magnetic stimulation for pd.
boolean
C0524850 (UMLS CUI [1,1])
C0030567 (UMLS CUI [1,2])
C0436548 (UMLS CUI [2,1])
C0030567 (UMLS CUI [2,2])
Malignant Neoplasms
Item
3. diagnosis of cancer within 5 years.
boolean
C0006826 (UMLS CUI [1])
Organ system Illness
Item
4. diagnosis of clinically significant illness of any organ system.
boolean
C0460002 (UMLS CUI [1,1])
C0221423 (UMLS CUI [1,2])
Dementia | Mini-mental state examination
Item
5. diagnosis of dementia or mini-mental status examination score of 25 or less.
boolean
C0497327 (UMLS CUI [1])
C0451306 (UMLS CUI [2])
Substance Use Disorders | Substance Dependence
Item
6. history of drug or alcohol abuse or dependence within the past two years.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
Psychotic Disorders
Item
7. history of psychosis.
boolean
C0033975 (UMLS CUI [1])
Drug Allergy
Item
8. significant drug allergies.
boolean
C0013182 (UMLS CUI [1])
Anticonvulsants Seizures
Item
9. taking anticonvulsants for seizures.
boolean
C0003286 (UMLS CUI [1,1])
C0036572 (UMLS CUI [1,2])
Malignant syndrome Neurologic
Item
10. history of neurological malignant syndrome.
boolean
C0948281 (UMLS CUI [1,1])
C0205494 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
11. pregnant or lactating females.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])